Anti-Breast Cancer Activity of Essential Oil: A Systematic Review
, Ade Zuhrotun 3, Nur Kusaira Khairul Ikram 4 and Muchtaridi Muchtaridi 1,5,*
Round 1
Reviewer 1 Report
Dear authors
The title of the article is not appropriate.
The authors mentioned only breast cancer in the title, while many cancers are discussed in the text, please change the title.
Recently, a new article has been published in this area, please explain different with this paper that recently published:
((Sharma M, Grewal K, Jandrotia R, Batish DR, Singh HP, Kohli RK. Essential oils as anticancer agents: Potential role in malignancies, drug delivery mechanisms, and immune system enhancement. Biomedicine & Pharmacotherapy. 2022 Feb 1;146:112514.))
In part 2. Methodology
You using databases of Scopus and Google Scholar please add pub med.
in part 3. Result
The following articles can be suitable for this article
Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers
Anticarcinogenic effect of chitosan nanoparticles containing syzygium aromaticum essential oil or eugenol toward breast and skin cancer cell lines
In conclusion: Explain the conclusion more fully
sincerely
Author Response
Dear Prof/Dr,
Thank you for the comments and suggestions which are of great value in improving our manuscript. We have carefully studied the comments and made a significant revision which we hope will meet your approval. The amendments as well as the minor/major corrections are highlighted in the manuscript.
REVIEWER 1
- Page 1, line 2: The title of the article is not appropriate. The authors mentioned only breast cancer in the title, while many cancers are discussed in the text, please change the title.
Author's response: Our paper actually is focused on breast cancer thus we wrote briefly in section 3.4. In this section, we explained more details than other cancers even we wrote section of future and prospect in Author Perspective is focused on breast cancer cases. We also have double-checked our findings and discovered that all of the breast cancer cell types utilized in journals that meet the criteria for inclusion are MCF-7, MDA-MB-231, MDA-MB-468, and breast cancer rat models. We also included the entire journal in the main chapter. Given the foregoing, in which all cell types and experimental animal models include breast cancer, we kindly request your permission not to change the journal's title because this is one of the novel themes we raise. Lines 330-650.
- Recently a new article has been published in this area, please explain different with this paper that recently published: ((Sharma M, Grewal K, Jandrotia R, Batish DR, Singh HP, Kohli RK. Essential oils as anticancer agents: Potential role in malignancies, drug delivery mechanisms, and immune system enhancement. Biomedicine & Pharmacotherapy. 2022 Feb 1;146:112514.))
Author's response: The main difference is that in our study, a systematic review was conducted with a breast cancer focus. (lines 330-650). We explained briefly in Section 3.4 (line 330) and we provide perspective on the Author's Perspective Section (line 640).
- Page 2, line 56-58: Methodology. You using databases of Scopus and Google Scholar please add pubmed.
Author's response: Thank you for the suggestion; it has been changed (line 61).
- Page 3, line 72: In result part: The following articles can be suitable for this article:
- Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers
- Anticarcinogenic effect of chitosan nanoparticles containing syzygium aromaticum essential oil or eugenol toward breast and skin cancer cell lines
Author's response: We appreciate your kindness and will consider over such articles. The both article already inside to results in line 625-631 page18.
- Page 18-19, line 651-660: In conclusion part: Explain the conclusion more fully
Author's response: Thanks to your suggestions, the conclusion has been changed (lines .
We appreciate your effort to improve our article.
Thank you for your kind attention
Muchtaridi
Reviewer 2 Report
Please see my comments in the attached file.
Comments for author File: 
Comments.pdf
Author Response
Dear Prof/Dr,
Thank you for the comments and suggestions which are of great value in improving our manuscript. We have carefully studied the comments and made a significant revision which we hope will meet your approval. The amendments as well as the minor/major corrections are highlighted in the manuscript.
REVIEWER 2
- Page 3, line 89-90: It is better this hypothesis is explained with a picture
Author's response: Thanks for your input, the picture has been included.
- Page 3, line 105-106: Please explain the advantages and disadvantages of the each method
Answer: Thanks for your input, the advantages and disadvantages have been included.
- Page 4, line 137: Why you are using this classification?. Please refer to any references
Author's response: Thank you for your inquiry. Once the inclusion and exclusion criteria are satisfied for all journals, the classification based on the essential oil's extraction method and type of essential oil is decided. This consideration was reached after reviewing objective studies from each journal.
- Page 4, line 144: Cite a reference
Author's response: The citation has been added “Cassel, E., Vargas, R. M. F., Martinez, N., Lorenzo, D., & Dellacassa, E. (2009). Steam distillation modeling for essential oil extraction process. Industrial crops and products, 29(1), 171-176.”
- Page 4, line146: How about other extraction methods like MAHD, OAHD, etc ?
Author's response: Thanks to your advice, the extraction method for MAHD and OHAD has been included.
- Page 5, line 189-190: Some EO is higest than water like clove oil
Author's response: Thanks to your suggestions, the sentence has been changed.
- Page 6, line 231: Check the name of plant
Author's response: It has been revised
- Page 6, line 255: Please complete the name of plant
Author's response: The plant name has been revised
- Page 7, table 1, row 6: Correct the name
Author's response: The plant name has been revised
- Page 8, table 1, row 10: Italic
Author's response: The format has been revised
- Page 8, table 1, row 12: Please mention the plant name, champhor is a compound
Author's response: The plant name has been revised
- Page 7-8 table 1. row 16, 17, 25, 28, 30, 33, 34, and 35: Correct the name, and cross check
Author's response: The plant name and the format has been revised
- Page 12, line 371: Chek the plant name
Author's response: The plant name has been revised
- Page 12, line 377: Add complete name
Author's response: The plant name has been revised
- Page 17, line 580: Italic and complete name
Author's response: The plant name has been revised
- Page 17-18, conclusion: This section must be rewrite again
Answer: The sentence has been revised
We appreciate your effort to improve our article.
Thank you for your kind attention
Muchtaridi
