NADPH Oxidases (NOXs)

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 420

Special Issue Editor


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Guest Editor
Vascular Biology Center, Medical College of Georgia at Augusta University, 1460 Laney Walker Blvd, CB 3316, Augusta, GA 30909, USA
Interests: obesity; hypertension; vascular function; insulin resistance; cardiometabolic dysfunction; NADPH oxidase (NOX)

Special Issue Information

Dear Colleagues,

NADPH oxidases (NOXs) represent a group of enzymes with pivotal roles in various physiological and pathological processes. These enzymes play a crucial role in producing reactive oxygen species (ROS), serving as key regulators of redox signaling in diverse cellular contexts. Their involvement in various pathophysiological states, ranging from cardiovascular and pulmonary diseases to renal disorders, neuronal dysfunctions, and cancer, is becoming increasingly evident.

This Special Issue is dedicated to exploring the complex landscape of NADPH oxidases (NOX), shedding light on their structure, function, regulation, and involvement in health and disease. As the Guest Editor, we invite you to contribute a paper to this Special Issue. Both research articles and comprehensive reviews will be welcome.

Prof. Dr. David W. Stepp
Guest Editor

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Keywords

  • NADPH oxidases
  • reactive oxygen species
  • redox signaling
  • cardiovascular diseases

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Published Papers (1 paper)

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Review

17 pages, 849 KiB  
Review
Role of NADPH Oxidases in Stroke Recovery
by Dong-Hee Choi, In-Ae Choi and Jongmin Lee
Antioxidants 2024, 13(9), 1065; https://doi.org/10.3390/antiox13091065 - 30 Aug 2024
Abstract
Stroke is one of the most significant causes of death and long-term disability globally. Overproduction of reactive oxygen species by NADPH oxidase (NOX) plays an important role in exacerbating oxidative stress and causing neuronal damage after a stroke. There is growing evidence that [...] Read more.
Stroke is one of the most significant causes of death and long-term disability globally. Overproduction of reactive oxygen species by NADPH oxidase (NOX) plays an important role in exacerbating oxidative stress and causing neuronal damage after a stroke. There is growing evidence that NOX inhibition prevents ischemic injury and that the role of NOX in brain damage or recovery depends on specific post-stroke phases. In addition to studies on post-stroke neuroprotection by NOX inhibition, recent reports have also demonstrated the role of NOX in stroke recovery, a critical process for brain adaptation and functional reorganization after a stroke. Therefore, in this review, we investigated the role of NOX in stroke recovery with the aim of integrating preclinical findings into potential therapeutic strategies to improve stroke recovery. Full article
(This article belongs to the Special Issue NADPH Oxidases (NOXs))
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