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Background:
Systematic Review

Efficacy of Thiocolchicoside for Musculoskeletal Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

by
Alessandro Bianconi
1,†,
Matteo Fiore
1,†,
Annalisa Rosso
2,
Cecilia Acuti Martellucci
1,*,
Giovanna Letizia Calò
2,
Giovanni Cioni
2,
Gianmarco Imperiali
2,
Vittorio Orazi
2,
Marco Tiseo
2,
Anastasia Troia
2 and
Enrico Zauli
3
1
School of Public Health, Department of Medical and Surgical Sciences, University of Bologna, Via San Giacomo 12, 40138 Bologna, Italy
2
Department of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, Italy
3
Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Clin. Med. 2024, 13(20), 6133; https://doi.org/10.3390/jcm13206133
Submission received: 5 September 2024 / Revised: 7 October 2024 / Accepted: 13 October 2024 / Published: 15 October 2024
(This article belongs to the Section Clinical Neurology)
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Abstract

Background: Despite the fact that thiocolchicoside has been widely used in the treatment of musculoskeletal pain, its efficacy has never been systematically evaluated. We carried out a systematic review and meta-analysis of randomized clinical trials (RCTs) to appraise the existing evidence on the efficacy of thiocolchicoside for musculoskeletal pain management. Methods: The literature search was performed on multiple databases, extracting reports of RCTs evaluating the efficacy of thiocolchicoside compared to placebo or no exposure. The reduction in pain intensity was evaluated through between-groups mean differences (MDs) in Visual Analogue Scale (VAS) scores after the intervention. The pooled effect estimates were compared to a minimally important difference (MID) of 1 point on a scale from 0 to 10. Results: We retrieved eight RCTs, including a total of 1397 patients. All the included studies were determined as being at high risk of bias. Seven trials evaluated patients with acute low back pain. After 2–3 days of treatment, the pooled MD in VAS score was −0.49 (95%CI = −0.90; −0.09) compared to controls. After 5–7 days of treatment, the summary MD was −0.82 (95%CI = −1.46; −0.18). Conclusions: Although thiocolchicoside was found to significantly reduce patient-reported low back pain, the clinical impact was very small, as the pooled effect estimates were below the MID, and the overall certainty of evidence was very low. In light of the safety concerns raised by the European Medicine Agency, an in-depth analysis on the risk–benefit balance of thiocolchicoside is required.
Keywords: thiocolchicoside; musculoskeletal pain; relaxant; pain management thiocolchicoside; musculoskeletal pain; relaxant; pain management

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MDPI and ACS Style

Bianconi, A.; Fiore, M.; Rosso, A.; Acuti Martellucci, C.; Calò, G.L.; Cioni, G.; Imperiali, G.; Orazi, V.; Tiseo, M.; Troia, A.; et al. Efficacy of Thiocolchicoside for Musculoskeletal Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J. Clin. Med. 2024, 13, 6133. https://doi.org/10.3390/jcm13206133

AMA Style

Bianconi A, Fiore M, Rosso A, Acuti Martellucci C, Calò GL, Cioni G, Imperiali G, Orazi V, Tiseo M, Troia A, et al. Efficacy of Thiocolchicoside for Musculoskeletal Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Clinical Medicine. 2024; 13(20):6133. https://doi.org/10.3390/jcm13206133

Chicago/Turabian Style

Bianconi, Alessandro, Matteo Fiore, Annalisa Rosso, Cecilia Acuti Martellucci, Giovanna Letizia Calò, Giovanni Cioni, Gianmarco Imperiali, Vittorio Orazi, Marco Tiseo, Anastasia Troia, and et al. 2024. "Efficacy of Thiocolchicoside for Musculoskeletal Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials" Journal of Clinical Medicine 13, no. 20: 6133. https://doi.org/10.3390/jcm13206133

APA Style

Bianconi, A., Fiore, M., Rosso, A., Acuti Martellucci, C., Calò, G. L., Cioni, G., Imperiali, G., Orazi, V., Tiseo, M., Troia, A., & Zauli, E. (2024). Efficacy of Thiocolchicoside for Musculoskeletal Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Clinical Medicine, 13(20), 6133. https://doi.org/10.3390/jcm13206133

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