Antibacterial and Anti-Inflammatory Coating Materials for Orthopedic Implants: A Review
Abstract
:1. Introduction
2. Coating Materials with Antibacterial Activity
2.1. Bactericidal Coating Materials
2.1.1. Chitosan
2.1.2. Quaternary Ammonium Compounds
2.1.3. Antibiotics
Gentamicin
Vancomycin
Rifampicin
2.1.4. Metals
Ag and AgNPs
Gold Nanoparticles
Copper and Copper Nanoparticles
Selenium Nanoparticles
Zinc Nanoparticles
Ti and Ti-Oxide
2.2. Bacteriostatic Surface Coating Materials
2.3. Antimicrobial Peptides with Bactericidal and Bacteriostatic Properties
3. Coating Materials with Anti-Inflammatory Activity
3.1. Anti-Inflammatory Materials Regulate Macrophage Polarization
3.2. Other Anti-Inflammatory Materials
4. Conclusions and Future Horizons
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
AgNPs | silver nanoparticles |
Ag | silver |
Ag-CuNPs | Ag/Cu nanoparticles |
ALP | alkaline phosphatase |
AMR | antimicrobial resistance |
AMPs | antimicrobial peptides |
ARG | arginine |
Au | gold |
AuNPs | gold nanoparticles |
BMSC | bone marrow stem cells |
CaO3 | calcium carbonate |
CMS | chymotrypsin |
CeO2 | cerium dioxide |
CM | Coumarin |
COX-2 | cyclooxygenase 2 |
CS | Chitosan |
CS-SeNPs | CS–se nanoparticles |
CSZP | calcium–strontium–zinc–phosphate coating |
CuAA | copper-catalyzed azide alkyne |
Cu | copper |
CuO | copper oxide |
CuONPs | CuO nanoparticles |
Cur | Curcumin |
CurNPs | curcumin nanoparticles |
DAIs | device-associated infections |
DNA | deoxyribonucleic acid |
DEX | dexamethasone |
ELISA | enzyme-linked immunosorbent assay |
EPS | extracellular polymeric substance |
EY | eosin Y |
GO | graphene oxide |
H+ | positive hole |
HA | hyaluronic acid |
HAp | hydroxyapatite |
IFN-γ | interferon-γ |
IL-1β | interleukin-1β |
IL-4 | interleukin 4 |
IL-6 | interleukin-6 |
IL-10 | interleukin 10 |
INOS | inducible nitric oxide synthase |
LPS | lipopolysaccharide |
MAO | micro arc oxidation |
mAbs | monoclonal antibodies |
MIC | minimum inhibitory concentrations |
MMP-3 | matrix metalloproteinase 3 |
MMT | montmorillonite |
mRNA | messenger ribonucleic acid |
MRSA | Methicillin-resistant S.aureus |
MRSE | methicillin-resistant S. epidermidis |
MSSA | methicillin-susceptible S. aureus |
N-CQDs | N-doped graphene quantum dots |
NF-kß | nuclear factor kβ |
n-HA/RES/CS | nano-hydroxyapatite/resveratrol/CS composite microspheres |
NO | nitric oxide |
NSAIDs | nonsteroidal anti-inflammatory and analgesic drugs |
OH- | hydroxide ions |
OH | hydroxyl radical |
O2- | superoxide ions |
OPG | osteoprotegerin |
OPGL | osteoprotegerin ligand |
ORIF | open reduction and internal fixation |
PCL | poly (caprolactone) |
PDA | polydopamine |
PDT | photodynamic therapy |
PEEKP | polyether ether ketone |
PEG | poly(ethylene glycol) |
PEO | poly(ethylene oxide) |
PGE | prostaglandin E |
PIII | plasma immersion ion implantation |
PJI | periprosthetic Joint Infection |
PLA | poly (lactic acid) |
PLGA | poly-dl-lactic-co-glycolic |
PLL | poly L-lysine |
PLLA | poly (L-lactide) |
PMM | poly(methyl methacrylate) |
PMPC | poly(2-methacryloyloxyethyl phosphorylcholine) |
PSBMA | polysulfobetaine methacrylate |
PSL | phosphatidylserine |
PTFEMA-r-SBMA | poly(trifluoroethyl methacrylate-random-sulfobetaine methacrylate) |
QACs | quaternary ammonium compounds |
QD | quantum dot |
RCT | randomized controlled trial |
RES | resveratrol |
ROS | reactive oxygen species |
RT-PCR | reverse-transcription polymerase chain reaction |
SAM | self-assembled monolayer |
S. aureus | Staphylococcus aureus |
SB2VP | sulfobetaine-2-vinylpyridine |
Se | selenium |
SeNPs | Se nanoparticles |
S. epidermidis | Staphylococcus epidermidis |
SLA | sandblasted and acid-etched |
TA | tannic acid |
TA-CaO3NPs | TA-CaO3 nanomaterials |
TGF-β3 | transforming growth factorβ3 |
THA | total hip arthroplasty |
Ti | titanium |
TiO2 | titanium dioxide |
TiO2-CuNPs | TiO2-Cu nanoparticles |
TJA | total joint arthroplasty |
TKA | total knee arthroplasty |
TNF-α | tumor necrosis factor-α |
TRP | tryptophan |
UV | ultraviolet |
VCM/nHAC/PLA | nano-HAp/collagen/poly(lactic acid) |
VRSA | Vancomycin resistant S.aureus |
ZnO | zinc oxide |
Zn | zinc |
ZnONPs | zinc oxide nanoparticles |
Zn2+ | zinc ions |
4VP | 4-vinylpyridine |
4VPPS | 4-vinylpyridine propylsulfobetaine |
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Tan, G.; Xu, J.; Chirume, W.M.; Zhang, J.; Zhang, H.; Hu, X. Antibacterial and Anti-Inflammatory Coating Materials for Orthopedic Implants: A Review. Coatings 2021, 11, 1401. https://doi.org/10.3390/coatings11111401
Tan G, Xu J, Chirume WM, Zhang J, Zhang H, Hu X. Antibacterial and Anti-Inflammatory Coating Materials for Orthopedic Implants: A Review. Coatings. 2021; 11(11):1401. https://doi.org/10.3390/coatings11111401
Chicago/Turabian StyleTan, Gang, Jing Xu, Walter Munesu Chirume, Jieyu Zhang, Hui Zhang, and Xuefeng Hu. 2021. "Antibacterial and Anti-Inflammatory Coating Materials for Orthopedic Implants: A Review" Coatings 11, no. 11: 1401. https://doi.org/10.3390/coatings11111401