Changes in 25-(OH) Vitamin D Levels during the SARS-CoV-2 Outbreak: Lockdown-Related Effects and First-to-Second Wave Difference—An Observational Study from Northern Italy
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. UV and Ozone Data
2.2. Clinical Data
2.3. Statistical Analysis
3. Results
3.1. Lockdown Effect
3.2. First Wave vs. Second Wave
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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SARS-CoV-2 + | SARS-CoV-2 − | ||||||
---|---|---|---|---|---|---|---|
Males | Females | Total | Males | Females | Total | p-Value | |
N | 83 (64.8%) | 45 (35.2%) | 128 (100%) | 107 (48.9%) | 112 (51.1%) | 219 (100%) | <0.05 * |
Age (years) | 62.7 ± 14.2 | 69.3 ± 15.6 | 65.0 ± 15.0 | 62.8 ± 19.5 | 54.3 ± 20.1 | 58.7 ± 20.2 | <0.05 |
25-(OH)D (ng/mL) | 19.7 ± 13.5 | 25.8 ± 19.6 | 21.8 ± 16.1 | 23.1 ± 15.0 | 22.6 ± 13.1 | 22.8 ± 14.0 | 0.39 |
SARS-CoV-2 + | |||
Males | Females | Total | |
N | 101 (53.7%) | 87 (46.3%) | 188 (100%) |
Age (years) | 58.9 ± 21.6 | 61.4 ± 18.8 | 60.0 ± 20.3 |
25-(OH)D (ng/mL) | 23.7 ± 11.5 ### | 26.7 ± 14.7 | 25.1 ± 13.2 |
SARS-CoV-2 − | |||
Males | Females | Total | |
N | 547 (46.1%) | 638 (53.9%) | 1185 (100%) |
Age (years) | 55.5 ± 23.9 | 54.0 ± 22.3 | 54.7 ± 23.0 |
25-(OH)D (ng/mL) | 24.9 ± 12.9 ### | 28.2 ± 13.5 | 26.7 ± 13.3 |
Whole population | |||
Males | Females | Total | |
N | 9164 (33.1%) | 18,520 (66.9%) | 27,684 (100%) |
Age (years) | 56.6 ± 19.6 | 59.0 ± 18.3 | 58.2 ± 18.8 |
25-(OH)D (ng/mL) | 29.0 ± 12.0 | 31.7 ± 13.5 | 30.8 ± 13.1 |
<46 | 46–65 | >65 | ||
---|---|---|---|---|
Females | ||||
25-(OH)D (ng/mL) | SARS-CoV-2 + | * (13) | 30.4 ± 14.8 (32) | 22.2 ± 13.5 (42) § ### |
SARS-CoV-2 – | 27.7 ± 11.3 (200) | 29.5 ± 14.2 (201) ## | 27.6 ± 14.4 (237) ### | |
Total | 29.2 ± 11.9 (3728) | 32.2 ± 13.3 (7490) | 32.7 ± 15.0 (7300) | |
Males | ||||
25-(OH)D (ng/mL) | SARS-CoV-2 + | 28.5 ± 10.6 (21) | 23.1 ± 12.8 (34) ## | 22.0 ± 10.5 (46) ## |
SARS-CoV-2 − | 26.5 ± 10.3 (161) ## | 26.2 ± 13.0 (147) ### | 23.1 ± 14.2 (239) ### | |
Total | 29.5 ± 11.6 (2335) | 29.4 ± 11.4 (3572) | 28.3 ± 13.8 (3257) |
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Ferrari, D.; Locatelli, M.; Faraldi, M.; Lombardi, G. Changes in 25-(OH) Vitamin D Levels during the SARS-CoV-2 Outbreak: Lockdown-Related Effects and First-to-Second Wave Difference—An Observational Study from Northern Italy. Biology 2021, 10, 237. https://doi.org/10.3390/biology10030237
Ferrari D, Locatelli M, Faraldi M, Lombardi G. Changes in 25-(OH) Vitamin D Levels during the SARS-CoV-2 Outbreak: Lockdown-Related Effects and First-to-Second Wave Difference—An Observational Study from Northern Italy. Biology. 2021; 10(3):237. https://doi.org/10.3390/biology10030237
Chicago/Turabian StyleFerrari, Davide, Massimo Locatelli, Martina Faraldi, and Giovanni Lombardi. 2021. "Changes in 25-(OH) Vitamin D Levels during the SARS-CoV-2 Outbreak: Lockdown-Related Effects and First-to-Second Wave Difference—An Observational Study from Northern Italy" Biology 10, no. 3: 237. https://doi.org/10.3390/biology10030237