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Open AccessArticle
Effects of Lipid Phase Content on the Technological and Sensory Properties of O/W Emulsions Containing Bemotrizinol-Loaded Nanostructured Lipid Carriers
by
Debora Santonocito
Debora Santonocito 1,2
,
Carmelo Puglia
Carmelo Puglia 1,2
and
Lucia Montenegro
Lucia Montenegro 1,2,*
1
Department of Drug and Health Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy
2
NANOMED—Centro di Ricerca in Nanomedicina e Nanotecnologie Farmaceutiche, University of Catania, V.le A. Doria 6, 95125 Catania, Italy
*
Author to whom correspondence should be addressed.
Cosmetics 2024, 11(4), 123; https://doi.org/10.3390/cosmetics11040123 (registering DOI)
Submission received: 15 April 2024
/
Revised: 27 June 2024
/
Accepted: 12 July 2024
/
Published: 19 July 2024
Abstract
Different lipid phase ratios (12, 14, and 16% w/w) were assessed for their ability to affect the technological and sensory properties of O/W emulsions in which bemotrizinol (BMTZ), a broad-spectrum sunscreen agent, was incorporated free or loaded into nanostructured lipid nanocarriers (NLC) to reduce its release from the vehicle and, hence, its skin permeation. The following technological properties were evaluated in vitro: spreadability, viscosity, pH, occlusion factor, BMTZ release, and sun protection factor (SPF). Sensory attributes were assessed by panelists in three different phases: before/during pick-up, rub-in, and after application. Raising the lipid phase ratio led to an increase in viscosity (from 8017 ± 143 cPs to 16,444 ± 770 cPs) and to a corresponding decrease in spreadability (from 9.35 ± 0.21 cm to 7.50 ± 0.10 cm), while the incorporation of BMTZ-loaded NLC determined a decrease in the occlusion factor (from 47.75 ± 1.16 to 25.91 ± 1.57) and an increase in SPF (from 6% for formulations containing 12% lipid phase to 15% for formulations containing 16% lipid phase). No BMTZ release was observed from all emulsions. Sensory attributes were mainly affected by the lipid phase ratio. These results suggest that the lipid phase ratio and BMTZ incorporation into NLC could contribute to determining the technological and sensory properties of O/W emulsions.
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MDPI and ACS Style
Santonocito, D.; Puglia, C.; Montenegro, L.
Effects of Lipid Phase Content on the Technological and Sensory Properties of O/W Emulsions Containing Bemotrizinol-Loaded Nanostructured Lipid Carriers. Cosmetics 2024, 11, 123.
https://doi.org/10.3390/cosmetics11040123
AMA Style
Santonocito D, Puglia C, Montenegro L.
Effects of Lipid Phase Content on the Technological and Sensory Properties of O/W Emulsions Containing Bemotrizinol-Loaded Nanostructured Lipid Carriers. Cosmetics. 2024; 11(4):123.
https://doi.org/10.3390/cosmetics11040123
Chicago/Turabian Style
Santonocito, Debora, Carmelo Puglia, and Lucia Montenegro.
2024. "Effects of Lipid Phase Content on the Technological and Sensory Properties of O/W Emulsions Containing Bemotrizinol-Loaded Nanostructured Lipid Carriers" Cosmetics 11, no. 4: 123.
https://doi.org/10.3390/cosmetics11040123
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