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Article

Alpha-Bisabolol-Loaded Cosmetic Micellar Solution with Cleansing and Antimicrobial Action for Facial Skin Hygiene

by
Nadezhda Ivanova
1,*,
Neli Ermenlieva
2 and
Velichka Andonova
1
1
Department of Pharmaceutical Technologies, Faculty of Pharmacy, Medical University of Varna, 9000 Varna, Bulgaria
2
Department of Microbiology and Virology, Faculty of Medicine, Medical University of Varna, 9000 Varna, Bulgaria
*
Author to whom correspondence should be addressed.
Cosmetics 2024, 11(5), 173; https://doi.org/10.3390/cosmetics11050173
Submission received: 19 August 2024 / Revised: 22 September 2024 / Accepted: 27 September 2024 / Published: 1 October 2024
(This article belongs to the Special Issue Nanotechnology Advances in Cosmetics)

Abstract

The current research is focused on the discovery and optimization of an effective cosmetic carrier of alpha-bisabolol as a first step in the development of a cosmetic product with cleansing and antimicrobial action for facial skin hygiene. A micellar solution of Poloxamer 407 was selected as a cosmetic base because of the good washing ability, easy application, and high tolerability of this polymeric surfactant. The solubilization capacity of a 5% micellar solution with respect to α-bisabolol was investigated by applying varying solubilization techniques and increasing concentrations of the oily active substance. The test samples were subjected to an accelerated physical stability test, viscosimetry, dynamic light scattering (DLS), electrophoretic light scattering (ELS), foamability test, and antimicrobial screening. Over the course of this research, the advantage of the film-hydration method over direct solubilization was demonstrated by the narrower size distribution and smaller hydrodynamic size of the micellar nano-carriers (ranging from 29.02 to 116.5 nm) and the respective higher physical stability of the dispersions. The optimized composition was found to be suitable for application on large skin areas in terms of viscosity in the temperature range from 20 °C to 40 °C (3.4–2.3 mPa.s). Preservation of the washing capacity of the micellar solution in the presence of solubilized α-bisabolol was established. The active composition demonstrated inhibitory activity against Staphylococcus aureus and Escherichia coli and fungicidal activity against Candida albicans. This study concludes that the optimal concentration of α-bisabolol to be solubilized in a 5% Poloxamer 407 micellar solution by the film-hydration technique is 1%, considering the desirable physical endurance and antimicrobial activity.
Keywords: bisabolol; poloxamer; solubilization; film hydration; microemulsions; nano-carriers; micellar solution; cosmetic skin care bisabolol; poloxamer; solubilization; film hydration; microemulsions; nano-carriers; micellar solution; cosmetic skin care

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MDPI and ACS Style

Ivanova, N.; Ermenlieva, N.; Andonova, V. Alpha-Bisabolol-Loaded Cosmetic Micellar Solution with Cleansing and Antimicrobial Action for Facial Skin Hygiene. Cosmetics 2024, 11, 173. https://doi.org/10.3390/cosmetics11050173

AMA Style

Ivanova N, Ermenlieva N, Andonova V. Alpha-Bisabolol-Loaded Cosmetic Micellar Solution with Cleansing and Antimicrobial Action for Facial Skin Hygiene. Cosmetics. 2024; 11(5):173. https://doi.org/10.3390/cosmetics11050173

Chicago/Turabian Style

Ivanova, Nadezhda, Neli Ermenlieva, and Velichka Andonova. 2024. "Alpha-Bisabolol-Loaded Cosmetic Micellar Solution with Cleansing and Antimicrobial Action for Facial Skin Hygiene" Cosmetics 11, no. 5: 173. https://doi.org/10.3390/cosmetics11050173

APA Style

Ivanova, N., Ermenlieva, N., & Andonova, V. (2024). Alpha-Bisabolol-Loaded Cosmetic Micellar Solution with Cleansing and Antimicrobial Action for Facial Skin Hygiene. Cosmetics, 11(5), 173. https://doi.org/10.3390/cosmetics11050173

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