Skip Content
You are currently on the new version of our website. Access the old version .

Metabolites, Volume 9, Issue 6

2019 June - 17 articles

Cover Story: Phosphatidylcholines (PC) are major constituents of eukaryotic cell membranes and represent important components of lipoproteins. Modern lipidomics approaches allow quantification of these lipids at different structural resolutions in blood from large human cohorts. Bulk PC measures, representing sums of isobaric PCs with different lipid side-chain compositions were shown to associate with various diseases and genetic variation. However, functional interpretation of these associations is limited without knowing their compositions in terms of fatty acid lengths and desaturation. In this paper, we characterized the constituents of PC sums by comparison with side-chain resolving measures for the same samples. In addition to identifying the major constituents of PC sums, our work highlighted relatively high abundance of less expected compositions, such as a high proportion of PCs with C22:6 and odd-numbered fatty acid chains. View this paper

Articles (17)

  • Article
  • Open Access
18 Citations
4,848 Views
19 Pages

Metabolomic Variability of Different Genotypes of Cashew by LC-Ms and Correlation with Near-Infrared Spectroscopy as a Tool for Fast Phenotyping

  • Elenilson Alves Filho,
  • Lorena Mara Silva,
  • Ynayara Lima,
  • Paulo Ribeiro,
  • Ebenézer Silva,
  • Guilherme Zocolo,
  • Kirley Canuto,
  • Selene Morais,
  • Ana Cecília Castro and
  • Edy de Brito

The objective of the present work was to develop an advanced fast phenotyping tool to explore the cashew apple compositions from different genotypes, based on a portable near-infrared (MicroNIR) spectroscopy. This will be in addition to associating t...

  • Article
  • Open Access
47 Citations
9,236 Views
15 Pages

Mass Spectrometry Data Repository Enhances Novel Metabolite Discoveries with Advances in Computational Metabolomics

  • Hiroshi Tsugawa,
  • Aya Satoh,
  • Haruki Uchino,
  • Tomas Cajka,
  • Makoto Arita and
  • Masanori Arita

Mass spectrometry raw data repositories, including Metabolomics Workbench and MetaboLights, have contributed to increased transparency in metabolomics studies and the discovery of novel insights in biology by reanalysis with updated computational met...

  • Article
  • Open Access
18 Citations
4,667 Views
21 Pages

Identifying Metabolomic Profiles of Insulinemic Dietary Patterns

  • Fred K. Tabung,
  • Raji Balasubramanian,
  • Liming Liang,
  • Steven K. Clinton,
  • Elizabeth M. Cespedes Feliciano,
  • JoAnn E. Manson,
  • Linda Van Horn,
  • Jean Wactawski-Wende,
  • Clary B. Clish and
  • Kathryn M. Rexrode
  • + 1 author

The food-based empirical dietary index for hyperinsulinemia (EDIH) score assesses the insulinemic potential of diet. This cross-sectional study evaluated associations between EDIH scores from food frequency questionnaires with c-peptide concentration...

  • Article
  • Open Access
12 Citations
6,483 Views
14 Pages

A Quantitative HILIC–MS/MS Assay of the Metabolic Response of Huh-7 Cells Exposed to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

  • Qing Liu,
  • Jingwei Cai,
  • Robert G. Nichols,
  • Yuan Tian,
  • Jintao Zhang,
  • Philip B. Smith,
  • Yan Wang,
  • Chao Yan and
  • Andrew D. Patterson

A hydrophilic interaction liquid chromatography (HILIC)–ultra high-pressure liquid chromatography (UHPLC) coupled with tandem mass spectrometry (MS/MS) method was developed and applied to profile metabolite changes in human Huh-7 cells exposed...

  • Review
  • Open Access
63 Citations
9,682 Views
27 Pages

Integration of Metabolomic and Other Omics Data in Population-Based Study Designs: An Epidemiological Perspective

  • Su H. Chu,
  • Mengna Huang,
  • Rachel S. Kelly,
  • Elisa Benedetti,
  • Jalal K. Siddiqui,
  • Oana A. Zeleznik,
  • Alexandre Pereira,
  • David Herrington,
  • Craig E. Wheelock and
  • on behalf of the Consortium of Metabolomics Studies Statistics Working Group
  • + 6 authors

It is not controversial that study design considerations and challenges must be addressed when investigating the linkage between single omic measurements and human phenotypes. It follows that such considerations are just as critical, if not more so,...

  • Article
  • Open Access
20 Citations
4,698 Views
17 Pages

Comparison of the Serum Metabolic Fingerprint of Different Exercise Modes in Men with and without Metabolic Syndrome

  • Aikaterina Siopi,
  • Olga Deda,
  • Vasiliki Manou,
  • Ioannis Kosmidis,
  • Despina Komninou,
  • Nikolaos Raikos,
  • Georgios A. Theodoridis and
  • Vassilis Mougios

Exercise plays a beneficial role in the treatment of metabolic syndrome (MetS). Metabolomics can provide new insights and facilitate the optimization of exercise prescription. This study aimed to investigate whether the response of the human serum me...

  • Article
  • Open Access
31 Citations
8,066 Views
24 Pages

Euglena Central Metabolic Pathways and Their Subcellular Locations

  • Sahutchai Inwongwan,
  • Nicholas J. Kruger,
  • R. George Ratcliffe and
  • Ellis C. O’Neill

Euglenids are a group of algae of great interest for biotechnology, with a large and complex metabolic capability. To study the metabolic network, it is necessary to know where the component enzymes are in the cell, but despite a long history of rese...

  • Article
  • Open Access
13 Citations
4,895 Views
19 Pages

Comparative Metabolomics of Early Development of the Parasitic Plants Phelipanche aegyptiaca and Triphysaria versicolor

  • Kristen Clermont,
  • Yaxin Wang,
  • Siming Liu,
  • Zhenzhen Yang,
  • Claude W. dePamphilis,
  • John I. Yoder,
  • Eva Collakova and
  • James H. Westwood

Parasitic weeds of the family Orobanchaceae attach to the roots of host plants via haustoria capable of drawing nutrients from host vascular tissue. The connection of the haustorium to the host marks a shift in parasite metabolism from autotrophy to...

  • Article
  • Open Access
68 Citations
11,275 Views
21 Pages

Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington’s Disease

  • Stefano Patassini,
  • Paul Begley,
  • Jingshu Xu,
  • Stephanie J. Church,
  • Nina Kureishy,
  • Suzanne J. Reid,
  • Henry J. Waldvogel,
  • Richard L. M. Faull,
  • Russell G. Snell and
  • Garth J. S. Cooper
  • + 1 author

Huntington’s disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in exon 1 of the HTT gene. HD usually manifests in mid-life with loss of GABAergic projection neurons from the striatum accompanied by progressive atrophy of t...

  • Review
  • Open Access
45 Citations
7,185 Views
19 Pages

An Updated Overview of Metabolomic Profile Changes in Chronic Obstructive Pulmonary Disease

  • Nan Ran,
  • Zhiqiang Pang,
  • Yinuo Gu,
  • He Pan,
  • Xu Zuo,
  • Xuewa Guan,
  • Yuze Yuan,
  • Ziyan Wang,
  • Yingqiao Guo and
  • Fang Wang
  • + 1 author

Chronic obstructive pulmonary disease (COPD), a common and heterogeneous respiratory disease, is characterized by persistent and incompletely reversible airflow limitation. Metabolomics is applied to analyze the difference of metabolic profile based...

  • Article
  • Open Access
26 Citations
4,768 Views
13 Pages

Dynamic Changes of Plasma Metabolome in Response to Severe Feed Restriction in Pregnant Ewes

  • Changzheng Guo,
  • Yanfeng Xue,
  • Hossam-eldin Seddik,
  • Yuyang Yin,
  • Fan Hu and
  • Shengyong Mao

Maternal metabolic disorders in ewes induced by energy deficiency have a detrimental effect on the maternal health and lambs. However, the dynamic processes of metabolic disorders are unknown. Therefore, this study attempted to explore the dynamic ch...

  • Article
  • Open Access
10 Citations
4,084 Views
8 Pages

Secondary Metabolites of Aeromonas veronii Strain A134 Isolated from a Microcystis aeruginosa Bloom

  • Gad Weiss,
  • Dimitry Kovalerchick,
  • Omer Murik,
  • Assaf Sukenik,
  • Aaron Kaplan and
  • Shmuel Carmeli

Aeromonas veronii strain A134 was isolated from Microcystis aeruginosa colonies collected from Lake Kinneret (Sea of Galilee), Israel. The Aeromonas culture media inhibited the growth of M. aeruginosa (strain MGK). The crude extract of a large-scale...

  • Article
  • Open Access
22 Citations
7,281 Views
18 Pages

Characterization of Bulk Phosphatidylcholine Compositions in Human Plasma Using Side-Chain Resolving Lipidomics

  • Jan D. Quell,
  • Werner Römisch-Margl,
  • Mark Haid,
  • Jan Krumsiek,
  • Thomas Skurk,
  • Anna Halama,
  • Nisha Stephan,
  • Jerzy Adamski,
  • Hans Hauner and
  • Gabi Kastenmüller
  • + 4 authors

Kit-based assays, such as AbsoluteIDQTM p150, are widely used in large cohort studies and provide a standardized method to quantify blood concentrations of phosphatidylcholines (PCs). Many disease-relevant associations of PCs were reported using this...

  • Conference Report
  • Open Access
19 Citations
6,367 Views
11 Pages

Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium

  • Pei Zhang,
  • Manish Arora,
  • Romanas Chaleckis,
  • Tomohiko Isobe,
  • Mohit Jain,
  • Isabel Meister,
  • Erik Melén,
  • Matthew Perzanowski,
  • Federico Torta and
  • Craig E. Wheelock
  • + 1 author

The attempt to describe complex diseases by solely genetic determination has not been successful. There is increasing recognition that the development of disease is often a consequence of interactions between multiple genetic and environmental factor...

  • Article
  • Open Access
9 Citations
5,618 Views
12 Pages

We succeeded in simultaneously synthesizing the vitamin D family, vitamins D2, D4, D5, D6, and D7, from β-sitosterol, which is sold as a commercially available reagent from Tokyo Chemical Industry Co., Ltd. It is officially sold as a mixture of...

  • Perspective
  • Open Access
185 Citations
12,270 Views
25 Pages

Translational Metabolomics: Current Challenges and Future Opportunities

  • Farhana R. Pinu,
  • Seyed Ali Goldansaz and
  • Jacob Jaine

Metabolomics is one of the latest omics technologies that has been applied successfully in many areas of life sciences. Despite being relatively new, a plethora of publications over the years have exploited the opportunities provided through this dat...

  • Article
  • Open Access
11 Citations
4,573 Views
13 Pages

Exo-Metabolites of Phaseolus vulgaris-Nodulating Rhizobial Strains

  • Diana Montes-Grajales,
  • Nuria Esturau-Escofet,
  • Baldomero Esquivel and
  • Esperanza Martinez-Romero

Rhizobia are able to convert dinitrogen into biologically available forms of nitrogen through their symbiotic association with leguminous plants. This results in plant growth promotion, and also in conferring host resistance to different types of str...

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Metabolites - ISSN 2218-1989