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Metabolites, Volume 9, Issue 8

2019 August - 16 articles

Cover Story: Enniatins (ENNs) are fungal secondary metabolites that frequently occur in grain in temperate climates. Their toxic potency is connected to their ionophoric character and lipophilicity. The biotransformation of ENNs predominantly takes place via cytochrome P450 3A (CYP 3A)-dependent oxidation reactions. In the present study, we determined the kinetic characteristics and inhibitory potential of ENNB1 in human liver microsomes and CYP3A4-containing nanodiscs. Considering the importance of CYP3A4 in the metabolism of ENNB1 in vitro, the potential for drug–drug interactions was studied using deoxynivalenol (DON), one of the most prevalent Fusarium mycotoxins in grain. Although DON was not metabolized by CYP3A4 or binding to its active site, the metabolite formation rates of ENNB1 and the frequently used drugs progesterone and atorvastatin lactone were noticeably reduced, indicating a certain binding affinity of DON to the enzyme. View this p

Articles (16)

  • Article
  • Open Access
15 Citations
5,582 Views
13 Pages

Far-Red Light Acclimation for Improved Mass Cultivation of Cyanobacteria

  • Alla Silkina,
  • Bethan Kultschar and
  • Carole A. Llewellyn

19 August 2019

Improving mass cultivation of cyanobacteria is a goal for industrial biotechnology. In this study, the mass cultivation of the thermophilic cyanobacterium Chlorogloeopsis fritschii was assessed for biomass production under light-emitting diode white...

  • Review
  • Open Access
102 Citations
10,711 Views
19 Pages

Advances of Metabolomics in Fungal Pathogen–Plant Interactions

  • Fangfang Chen,
  • Ruijing Ma and
  • Xiao-Lin Chen

15 August 2019

Plant disease caused by fungus is one of the major threats to global food security, and understanding fungus–plant interactions is important for plant disease control. Research devoted to revealing the mechanisms of fungal pathogen–plant...

  • Article
  • Open Access
10 Citations
4,301 Views
15 Pages

NMR Based Metabolomic Analysis of Health Promoting Phytochemicals in Lentils

  • Simone Rochfort,
  • Simone Vassiliadis,
  • Pankaj Maharjan,
  • Jason Brand and
  • Joe Panozzo

13 August 2019

Lentils are a high-protein plant food and a valuable source of human nutrition, particularly in the Indian subcontinent. However, beyond sustenance, there is evidence that the consumption of lentils (and legumes in general) is associated with decreas...

  • Article
  • Open Access
8 Citations
4,368 Views
20 Pages

12 August 2019

Metabolomics-based approaches are still receiving growing attention with regard to food authenticity testing. Such studies require enormous sample numbers with negligible experimental or analytical variations to obtain statistically reliable results....

  • Article
  • Open Access
31 Citations
8,476 Views
15 Pages

Microbial Transformations of Organically Fermented Foods

  • Ruma Raghuvanshi,
  • Allyssa G. Grayson,
  • Isabella Schena,
  • Onyebuchi Amanze,
  • Kezia Suwintono and
  • Robert A. Quinn

10 August 2019

Fermenting food is an ancient form of preservation ingrained many in human societies around the world. Westernized diets have moved away from such practices, but even in these cultures, fermented foods are seeing a resurgent interested due to their b...

  • Article
  • Open Access
9 Citations
4,147 Views
19 Pages

10 August 2019

Bambusa pervariabilis McClure × Dendrocalamopsis grandis (Q.H.Dai & X.l.Tao ex Keng f.) Ohrnb. blight is a widespread and dangerous forest fungus disease, and has been listed as a supplementary object of forest phytosanitary measures. In or...

  • Review
  • Open Access
97 Citations
8,831 Views
15 Pages

Metabolomics-Based Studies Assessing Exercise-Induced Alterations of the Human Metabolome: A Systematic Review

  • Camila A. Sakaguchi,
  • David C. Nieman,
  • Etore F. Signini,
  • Raphael M. Abreu and
  • Aparecida M. Catai

9 August 2019

This systematic review provides a qualitative appraisal of 24 high-quality metabolomics-based studies published over the past decade exploring exercise-induced alterations of the human metabolome. Of these papers, 63% focused on acute metabolite chan...

  • Article
  • Open Access
28 Citations
5,637 Views
12 Pages

The Biosynthetic Pathway of Major Avenanthramides in Oat

  • Zhiyong Li,
  • Yi Chen,
  • Dauenpen Meesapyodsuk and
  • Xiao Qiu

7 August 2019

Avenanthramides are a group of N-cinnamoylanthranilic acids, with health-promoting properties mainly found in oat (Avena sativa L.). However, the biosynthetic mechanism for the main three types of avenanthramides (Avn-A, Avn-B and Avn-C) is not compl...

  • Article
  • Open Access
3 Citations
4,257 Views
14 Pages

rMSIKeyIon: An Ion Filtering R Package for Untargeted Analysis of Metabolomic LDI-MS Images

  • Esteban del Castillo,
  • Lluc Sementé,
  • Sònia Torres,
  • Pere Ràfols,
  • Noelia Ramírez,
  • Manuela Martins-Green,
  • Manel Santafe and
  • Xavier Correig

2 August 2019

Many MALDI-MS imaging experiments make a case versus control studies of different tissue regions in order to highlight significant compounds affected by the variables of study. This is a challenge because the tissue samples to be compared come from d...

  • Article
  • Open Access
15 Citations
6,109 Views
14 Pages

Improved Small Molecule Identification through Learning Combinations of Kernel Regression Models

  • Céline Brouard,
  • Antoine Bassé,
  • Florence d’Alché-Buc and
  • Juho Rousu

1 August 2019

In small molecule identification from tandem mass (MS/MS) spectra, input–output kernel regression (IOKR) currently provides the state-of-the-art combination of fast training and prediction and high identification rates. The IOKR approach can be...

  • Article
  • Open Access
19 Citations
4,802 Views
12 Pages

Comparative Metabolomic Analysis of Rapeseeds from Three Countries

  • Ruinan Yang,
  • Ligang Deng,
  • Liangxiao Zhang,
  • Xiaofeng Yue,
  • Jin Mao,
  • Fei Ma,
  • Xiupin Wang,
  • Qi Zhang,
  • Wen Zhang and
  • Peiwu Li

1 August 2019

Rapeseed is an important oilseed with proper fatty acid composition and abundant bioactive components. Canada and China are the two major rapeseed-producing countries all over the world. Meanwhile, Canada and Mongolia are major importers of rapeseed...

  • Article
  • Open Access
10 Citations
3,495 Views
10 Pages

Adipocyte fatty acid-binding protein (A-FABP) is abundantly found in mature adipocytes and is involved in cardiovascular disease. Our aim is to investigate the association between serum A-FABP levels and endothelial function among kidney transplant (...

  • Article
  • Open Access
16 Citations
5,062 Views
17 Pages

Biotransformation of the Mycotoxin Enniatin B1 by CYP P450 3A4 and Potential for Drug-Drug Interactions

  • Lada Ivanova,
  • Ilia G. Denisov,
  • Yelena V. Grinkova,
  • Stephen G. Sligar and
  • Christiane K. Fæste

Enniatins (ENNs) are fungal secondary metabolites that frequently occur in grain in temperate climates. Their toxic potency is connected to their ionophoric character and lipophilicity. The biotransformation of ENNs predominantly takes place via cyto...

  • Review
  • Open Access
151 Citations
16,243 Views
20 Pages

Pre-Analytical Factors that Affect Metabolite Stability in Human Urine, Plasma, and Serum: A Review

  • Victoria L. Stevens,
  • Elise Hoover,
  • Ying Wang and
  • Krista A. Zanetti

Metabolomics provides a comprehensive assessment of numerous small molecules in biological samples. As it integrates the effects of exogenous exposures, endogenous metabolism, and genetic variation, metabolomics is well-suited for studies examining m...

  • Article
  • Open Access
39 Citations
7,357 Views
15 Pages

Bronchoalveolar Lavage Fluid from COPD Patients Reveals More Compounds Associated with Disease than Matched Plasma

  • Eitan Halper-Stromberg,
  • Lucas Gillenwater,
  • Charmion Cruickshank-Quinn,
  • Wanda Kay O’Neal,
  • Nichole Reisdorph,
  • Irina Petrache,
  • Yonghua Zhuang,
  • Wassim W. Labaki,
  • Jeffrey L. Curtis and
  • Russell P. Bowler
  • + 6 authors

Smoking causes chronic obstructive pulmonary disease (COPD). Though recent studies identified a COPD metabolomic signature in blood, no large studies examine the metabolome in bronchoalveolar lavage (BAL) fluid, a more direct representation of lung c...

  • Article
  • Open Access
12 Citations
5,835 Views
13 Pages

Renal cell carcinoma (RCC) is a heterogeneous malignancy which often develops and progresses asymptomatically. Benign oncocytomas are morphologically similar to malignant chromophobe RCC and distinguishing between these two forms on cross-sectional i...

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Metabolites - ISSN 2218-1989