Assessing Protein Biomarkers to Detect Lethal Acute Traumatic Brain Injuries in Cerebrospinal Fluid
Abstract
:1. Introduction
2. Material/Methods
2.1. Sample Collection, Assessment and Selection
2.2. Statistical Analyses
3. Results
BDNF Significantly Correlates with Three Acute Phase Proteins in Acute Lethal TBIs
4. Discussion
4.1. Limitations
4.2. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Conflicts of Interest
References
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Biomarker | AUC | 95% Confidence Interval | Threshold Value | Sensitivity: Specificity Ratio [%] | Positive Likelihood Ratio | Accuracy [%] |
---|---|---|---|---|---|---|
TBI biomarker of the central nervous system | ||||||
S100B | 0.78 | 0.69–0.88 | 2267 ng/mL | 37.1:96.6 | 10.76 | 79 |
NSE | 0.82 | 0.73–0.90 | 598.5 ng/mL | 48.4:96.5 | 14.03 | 83 |
GFAP | 0.77 | 0.64–0.89 | 134.4 ng/mL | 40.5:94.4 | 7.29 | 78 |
BDNF | 0.91 | 0.83–0.99 | 11.1 pg/mL | 64.3:95.7 | 14.68 | 86 |
Acute phase proteins as TBI biomarkers | ||||||
IL-6 | 0.88 | 0.80–0.96 | 99.1 pg/mL | 63.8:95.7 | 14.68 | 86 |
Ferritin | 0.91 | 0.83–0.98 | 1.73 mg/L | 66.0:95.7 | 15.17 | 87 |
LDH | 0.84 | 0.75–0.93 | 16.71 µkat/L | 41.9:96.5 | 12.16 | 81 |
NGAL | 0.86 | 0.76–0.96 | 334.4 ng/mL | 61.5:94.1 | 10.46 | 84 |
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Zwirner, J.; Bohnert, S.; Franke, H.; Garland, J.; Hammer, N.; Möbius, D.; Tse, R.; Ondruschka, B. Assessing Protein Biomarkers to Detect Lethal Acute Traumatic Brain Injuries in Cerebrospinal Fluid. Biomolecules 2021, 11, 1577. https://doi.org/10.3390/biom11111577
Zwirner J, Bohnert S, Franke H, Garland J, Hammer N, Möbius D, Tse R, Ondruschka B. Assessing Protein Biomarkers to Detect Lethal Acute Traumatic Brain Injuries in Cerebrospinal Fluid. Biomolecules. 2021; 11(11):1577. https://doi.org/10.3390/biom11111577
Chicago/Turabian StyleZwirner, Johann, Simone Bohnert, Heike Franke, Jack Garland, Niels Hammer, Dustin Möbius, Rexson Tse, and Benjamin Ondruschka. 2021. "Assessing Protein Biomarkers to Detect Lethal Acute Traumatic Brain Injuries in Cerebrospinal Fluid" Biomolecules 11, no. 11: 1577. https://doi.org/10.3390/biom11111577