Synthesis of Protein-Oligonucleotide Conjugates

Watson, Emma E.; Winssinger, Nicolas

doi:10.3390/biom12101523

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Synthesis of Protein-Oligonucleotide Conjugates

by

Emma E. Watson

^1,*

and

Nicolas Winssinger

^2,*

¹

Department of Chemistry, School of Physical Sciences, The University of Adelaide, Adelaide, SA 5005, Australia

²

Department of Organic Chemistry, Faculty of Science, NCCR Chemical Biology, CH-1205 Geneva, Switzerland

^*

Authors to whom correspondence should be addressed.

Biomolecules 2022, 12(10), 1523; https://doi.org/10.3390/biom12101523

Submission received: 15 September 2022 / Revised: 17 October 2022 / Accepted: 18 October 2022 / Published: 20 October 2022

(This article belongs to the Collection Feature Papers in Biomacromolecules: Nucleic Acids)

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Abstract

Nucleic acids and proteins form two of the key classes of functional biomolecules. Through the ability to access specific protein-oligonucleotide conjugates, a broader range of functional molecules becomes accessible which leverages both the programmability and recognition potential of nucleic acids and the structural, chemical and functional diversity of proteins. Herein, we summarize the available conjugation strategies to access such chimeric molecules and highlight some key case study examples within the field to showcase the power and utility of such technology.

Keywords: oligonucleotides; proteins; bioconjugation

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MDPI and ACS Style

Watson, E.E.; Winssinger, N. Synthesis of Protein-Oligonucleotide Conjugates. Biomolecules 2022, 12, 1523. https://doi.org/10.3390/biom12101523

AMA Style

Watson EE, Winssinger N. Synthesis of Protein-Oligonucleotide Conjugates. Biomolecules. 2022; 12(10):1523. https://doi.org/10.3390/biom12101523

Chicago/Turabian Style

Watson, Emma E., and Nicolas Winssinger. 2022. "Synthesis of Protein-Oligonucleotide Conjugates" Biomolecules 12, no. 10: 1523. https://doi.org/10.3390/biom12101523

APA Style

Watson, E. E., & Winssinger, N. (2022). Synthesis of Protein-Oligonucleotide Conjugates. Biomolecules, 12(10), 1523. https://doi.org/10.3390/biom12101523

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Synthesis of Protein-Oligonucleotide Conjugates

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