Exosomes as Promising Therapeutic Tools for Regenerative Endodontic Therapy
and Xin Shi 1,2,3,*Round 1
Reviewer 1 Report
Comments and Suggestions for AuthorsQingyue Kong et al.: Exosomes as promising therapeutic tools for regenerative endodontic therapy
This review paper focuses on the roles and mechanisms of exosomes involved in regenerative endodontics and the clinical strategies and influencing factors of exosomes applied in dental pulp regeneration, for exploring and facilitating the therapeutic strategy of exosome-based regenerative endodontic procedures. The provided findings are informative for understanding the exosomes as promising therapeutic tools for regenerative endodontic therapy. However, there is major concerns in the following items. Thus, this study should be improved before consideration for publication in biomolecules as follows.
Major concerns
1) Abstract does not include the information regarding the roles and mechanisms of exosomes involved in regenerative endodontics and the clinical strategies and influencing factors of exosomes applied in dental pulp regeneration.
2) Figure 4H: The evaluation of histological sections is inadequate, because the dentin indicated by arrows is not reparative dentin but reactionary dentin, indicating that dental pulp had not been exposed by cavity preparation in the DPSC-Od-Exos and MDPC-derived odontogenic exosomes groups.
Comments on the Quality of English LanguageEnglish looks good.
Author Response
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Author Response.pdf
Reviewer 2 Report
Comments and Suggestions for AuthorsThe manuscript offers a comprehensive exploration of exosomes. Nevertheless, some considerations are suggested for refinement prior to publication.
In Section 2, it is advisable to incorporate a paragraph that briefly summarizes the lack of standardization in exosome isolations and culture conditions. Additionally, addressing the prevalent focus on animal models in current exosome research and underscoring the absence of clinical applications for human pulp regeneration would enhance the manuscript's completeness and relevance.
Moving on to Section 4, specifically Subsection 4.4, it is recommended to include a brief discussion on the classification of polymers used as scaffold materials for exosome transport. This could include an overview of both natural and synthetic polymers, providing readers with valuable context regarding the materials employed in facilitating exosome delivery.
In conclusion, while the manuscript stands as a compelling review, the incorporation of these suggested refinements would further enhance the reading and ensure its association with current standards in the dental field.
Review reference in line 403, 405. 635, 638, 645, 722, 733, 839.
Review the spelling of the word metabonomics in line 851
Consider to check the relevance of the following references 7, 27, 61
Author Response
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