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Open AccessReview
How Transcription Factor Clusters Shape the Transcriptional Landscape
by
Rahul Munshi
Rahul Munshi
Joseph Henry Laboratories of Physics and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
Biomolecules 2024, 14(7), 875; https://doi.org/10.3390/biom14070875 (registering DOI)
Submission received: 1 June 2024
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Revised: 14 July 2024
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Accepted: 16 July 2024
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Published: 20 July 2024
Abstract
In eukaryotic cells, gene transcription typically occurs in discrete periods of promoter activity, interspersed with intervals of inactivity. This pattern deviates from simple stochastic events and warrants a closer examination of the molecular interactions that activate the promoter. Recent studies have identified transcription factor (TF) clusters as key precursors to transcriptional bursting. Often, these TF clusters form at chromatin segments that are physically distant from the promoter, making changes in chromatin conformation crucial for promoter–TF cluster interactions. In this review, I explore the formation and constituents of TF clusters, examining how the dynamic interplay between chromatin architecture and TF clustering influences transcriptional bursting. Additionally, I discuss techniques for visualizing TF clusters and provide an outlook on understanding the remaining gaps in this field.
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MDPI and ACS Style
Munshi, R.
How Transcription Factor Clusters Shape the Transcriptional Landscape. Biomolecules 2024, 14, 875.
https://doi.org/10.3390/biom14070875
AMA Style
Munshi R.
How Transcription Factor Clusters Shape the Transcriptional Landscape. Biomolecules. 2024; 14(7):875.
https://doi.org/10.3390/biom14070875
Chicago/Turabian Style
Munshi, Rahul.
2024. "How Transcription Factor Clusters Shape the Transcriptional Landscape" Biomolecules 14, no. 7: 875.
https://doi.org/10.3390/biom14070875
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