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Biomolecules
Volume 15
Issue 5
10.3390/biom15050619
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Article

Field-Effect Transistor Based on Nanocrystalline Graphite for DNA Immobilization

by
Bianca Adiaconita
,
Eugen Chiriac
*,
Tiberiu Burinaru
,
Catalin Marculescu
,
Cristina Pachiu
,
Oana Brincoveanu
,
Octavian Simionescu
and
Marioara Avram
*
National Institute for Research and Development in Microtechnologies—IMT Bucharest, 126A Erou Iancu, Nicolae, 077190 Voluntari, Ilfov, Romania
*
Authors to whom correspondence should be addressed.
Biomolecules 2025, 15(5), 619; https://doi.org/10.3390/biom15050619
Submission received: 13 March 2025 / Revised: 15 April 2025 / Accepted: 23 April 2025 / Published: 25 April 2025
(This article belongs to the Special Issue Biomolecules and Materials Based Approaches in Biomedical Field: 2nd Edition)
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Abstract

In recent years, field-effect transistors (FETs) based on graphene have attracted significant interest due to their unique electrical properties and their potential for biosensing and molecular detection applications. This study uses FETs with a nanocrystalline graphite (NCG) channel to detect DNA nucleobases. The exceptional electronic properties of NCG, and its high surface area, enable strong π–π stacking interactions with DNA nucleobases, promoting efficient adsorption and stabilization of the biomolecules. The direct attachment of nucleobases to the NCG channel leads to substantial changes in the device’s electrical characteristics, which can be measured in real time to assess DNA binding and sequence recognition. This method enables highly sensitive, label-free DNA detection, opening up new possibilities for rapid genetic analysis and diagnostics. Understanding the interactions between DNA nucleobases and graphene-based materials is crucial for advancing genetic research and biotechnology, paving the way for more accurate and efficient diagnostic tools.
Keywords: field-effect transistor; graphene-related material; nucleobase; Dirac point; mobility; DNA technologies field-effect transistor; graphene-related material; nucleobase; Dirac point; mobility; DNA technologies

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MDPI and ACS Style

Adiaconita, B.; Chiriac, E.; Burinaru, T.; Marculescu, C.; Pachiu, C.; Brincoveanu, O.; Simionescu, O.; Avram, M. Field-Effect Transistor Based on Nanocrystalline Graphite for DNA Immobilization. Biomolecules 2025, 15, 619. https://doi.org/10.3390/biom15050619

AMA Style

Adiaconita B, Chiriac E, Burinaru T, Marculescu C, Pachiu C, Brincoveanu O, Simionescu O, Avram M. Field-Effect Transistor Based on Nanocrystalline Graphite for DNA Immobilization. Biomolecules. 2025; 15(5):619. https://doi.org/10.3390/biom15050619

Chicago/Turabian Style

Adiaconita, Bianca, Eugen Chiriac, Tiberiu Burinaru, Catalin Marculescu, Cristina Pachiu, Oana Brincoveanu, Octavian Simionescu, and Marioara Avram. 2025. "Field-Effect Transistor Based on Nanocrystalline Graphite for DNA Immobilization" Biomolecules 15, no. 5: 619. https://doi.org/10.3390/biom15050619

APA Style

Adiaconita, B., Chiriac, E., Burinaru, T., Marculescu, C., Pachiu, C., Brincoveanu, O., Simionescu, O., & Avram, M. (2025). Field-Effect Transistor Based on Nanocrystalline Graphite for DNA Immobilization. Biomolecules, 15(5), 619. https://doi.org/10.3390/biom15050619

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