The Journey of a Medicinal Plant throughout Science: Sphaeralcea angustifolia (Cav.) G. Don (Malvaceae)
Abstract
:1. Introduction
2. Ethnobotanical Background of S. angustifolia
3. Experimental Studies on S. angustifolia
3.1. Selection, Collection, and First Trials
3.2. Chemical Assessment
Extract | Biological Effect | Compounds | References | |
---|---|---|---|---|
Dichloromethane | Anti-inflammatory Immunomodulatory | p-Cumaric acid | [12,17,18] | |
Scopoletin | ||||
Esculetin | ||||
Esculin | ||||
α-Amyrin | ||||
β-Amyrin | ||||
β-Sitosterol | ||||
Ethanolic | Antiprotozoal | Apigenin | [13] | |
Protocatechuic acid | ||||
Tiliroside | ||||
Caffeic acid | ||||
Methanolic | Neuroprotective | Loliolide | [14,15] | |
Hexanic | Herbicid | Β-Eudesmol | ||
Phytol |
3.3. Anti-Inflammatory Evaluation
3.4. Pharmacokinetic Profile
3.5. Clinical Trials of S. angustifolia Wild Plant Extract
3.6. Biotechnological Procedures
4. Discussion
5. Materials and Methods
6. Conclusions
7. Patents
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
- Li, F.; Wang, Y.; Li, D.; Chen, Y.; Dou, Q.P. Are we seeing a resurgence in the use of natural products for new drug discovery? Expert Opin. Drug Discov. 2019, 14, 417–420. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Atanasov, A.G.; Zotchev, S.B.; Dirsch, V.M.; Orhan, I.E.; Banach, M.; Rollinger, J.M.; Barreca, D.; Weckwerth, W.; Bauer, R.; Bayer, E.A.; et al. Natural products in drug discovery: Advances and opportunities. Nat. Rev. Drug Discov. 2021, 20, 200–216. [Google Scholar] [CrossRef] [PubMed]
- Martínez, M. Catálogo de Nombres Vulgares y Científicos de Plantas Mexicanas; Fondo de Cultura Económica: Mexico City, Mexico, 1979; p. 429. [Google Scholar]
- Fryxell, P.A. Malvaceae of Mexico. Syst. Bot. Monogr. 1988, 25, 1–522. [Google Scholar] [CrossRef]
- Fryxell, P.A. Familia Malvaceae. Flora Bajío Reg. Adyac. México 1993, 16, 1–15. [Google Scholar] [CrossRef]
- Fryxell, P.A. The American genera of Malvaceae II. Brittonia 1997, 49, 204–269. [Google Scholar] [CrossRef]
- Calderón-Rzedowski, G.; Rzedowski, J. Flora Fanerogámica del Valle de México, 2nd ed.; Instituto de Ecología, A.C. y Comisión Nacional para el Conocimiento y Uso de la Biodiversidad: Pátzcuaro, Michoacán, Mexico, 2005; p. 1406.
- Aguilar, A.; Camacho, R.; Chino, S. Herbario Medicinal del Instituto Mexicano del Seguro Social; Instituto Mexicano del Seguro Social: Mexico City, Mexico, 1994; Volmue 1, pp. 30–35.
- Argueta, V.A.; Cano, L.; Rodarte, M. Atlas de las Plantas de la Medicina Tradicional Mexicana; Instituto Nacional Indigenista (INI): Mexico City, Mexico, 1994; Volume III.
- Biblioteca Digital de la Medicina Tradiciona Atlas de las Plantas de la Medicina Tradicional Mexicana. Available online: http://www.medicinatradicionalmexicana.unam.mx/apmtm/index.html (accessed on 10 October 2022).
- Meckes, M.; David-Rivera, A.D.; Nava-Aguilar, V.; Jimenez, A. Activity of some Mexican medicinal plant extracts on carrageenan-induced rat paw edema. Phytomedicine 2004, 11, 446–451. [Google Scholar] [CrossRef] [PubMed]
- García-Rodríguez, R.V.; Chamorro Cevallos, G.; Siordia, G.; Jiménez-Arellanes, M.A.; Chávez-Soto, M.A.; Meckes-Fischer, M. Sphaeralcea angustifolia (Cav.) G. Don extract, a potential phytomedicine to treat chronic inflammation. Bol. Latinoam. Caribe Plantas Med. Aromat. 2012, 11, 454–463. [Google Scholar]
- Calzada, F.; Basurto, J.C.; Barbosa, E.; Velázquez, C.; Hernández, N.G.; Ordoñez Razo, R.M.; Luna, D.M.; Mulia, L.Y. Antiprotozoal activities of tiliroside and other compounds from Sphaeralcea angustifolia (Cav.) G. Don. Pharmacogn. Res. 2017, 9, 133–137. [Google Scholar]
- Osti-Castillo, M.; Torres-Valencia, J.J.M.; Villagómez-Ibarra, J.R.; Castelán-Pelcastre, I. Estudio químico de cinco plantas mexicanas de uso común en la medicina tradicional. Bol. Latinoam. Caribe Plantas Med. Aromat. 2010, 9, 359–367. [Google Scholar]
- King-Díaz, B.; Candelario-Mosco, E.C.; Altamirano García, E.D.; Aguilar-Laurents, M.I.; Lotina Hennnsen, B. Metabolitos secundarios con posible actividad herbicida, aislados de las flores de Sphaeralcea angustifolia. Rev. Latinoam. Química 2015, 43, 155. [Google Scholar]
- Pérez-Hernández, J.; González-Cortazar, M.; Marquina, S.; Herrera-Ruiz, M.; Meckes-Fischer, M.; Tortoriello, J.; Cruz-Sosa, F.; Nicasio-Torres, M.D.P. Sphaeralcic acid and tomentin, anti-inflammatory compounds produced in cell suspension cultures of Sphaeralcea angustifolia. Planta Med. 2014, 80, 209–214. [Google Scholar] [CrossRef] [Green Version]
- Juárez-Ciriaco, M. Efecto del Extracto Diclorometánico de Sphaeralcea angustifolia Sobre la Expresión de Citocinas pro y Antiinflamatorias en un Modelo de Ratas Artríticas. Master’s Thesis, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City, Mexico, 2008. [Google Scholar]
- Juárez-Ciriaco, M.; Román-Ramos, R.; González-Márquez, H.; Meckes-Fischer, M. Efecto de Sphaeralcea angustifolia sobre la expresión de citocinas pro y antiinflamatorias. LabCiencia 2008, 2, 21–23. [Google Scholar]
- Serrano-Román, J. Caracterización Farmacológica de Tomentina y Ácido Sphaeralcico Aislados de Suspensiones Celulares de Sphaeralcea angustifolia en un Modelo de Artritis Experimental. Master’s Thesis, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico, 2015. [Google Scholar]
- Nicasio-Torres, M.P.; Serrano-Román, J.; Pérez-Hernández, J.; Jiménez-Ferrer, E.; Herrera-Ruiz, M. Effect of dichloromethane-methanol extract and tomentin obtained from Sphaeralcea angustifolia cell suspensions in a model of kaolin/carrageenan-induced arthritis. Planta Med. Int. Open 2017, 4, e35–e42. [Google Scholar]
- Kim, H.J.; Jang, S.I.; Kim, Y.J.; Chung, H.T.; Yun, Y.G.; Kang, T.H.; Jeong, O.S.; Kim, Y.C. Scopoletin suppresses pro-inflammatory cytokines and PGE2 from LPS-stimulated cell line, RAW 264.7 cells. Fitoterapia 2004, 75, 261–266. [Google Scholar] [CrossRef] [PubMed]
- Moon, P.D.; Lee, B.H.; Jeong, H.J.; An, H.J.; Park, S.J.; Kim, H.R.; Ko, S.G.; Um, J.Y.; Hong, S.H.; Kim, H.M. Use of scopoletin to inhibit the production of inflammatory cytokines through inhibition of the IκB/NF-κB signal cascade in the human mast cell line HMC-1. Eur. J. Pharmacol. 2007, 555, 218–225. [Google Scholar] [CrossRef] [PubMed]
- Ding, Z.; Dai, Y.; Hao, H.; Pan, R.; Yao, X.; Wang, Z. Anti-inflammatory effects of scopoletin and underlying mechanisms. Pharm. Biol. 2008, 46, 854–860. [Google Scholar] [CrossRef]
- Reyes-Pérez, R.; Herrera-Ruiz, M.; Perea-Arango, I.; Martínez-Morales, F.; De Jesús Arellano García, J.; Nicasio-Torres, P. Anti-inflammatory compounds produced in hairy roots culture of Sphaeralcea angustifolia. Plant Cell. Tissue Organ Cult. 2022, 149, 351–361. [Google Scholar] [CrossRef]
- Andersen, M.L.; Santos, E.H.R.; Seabra, M.D.L.V.; Da Silva, A.A.B.; Tufik, S. Evaluation of acute and chronic treatments with Harpagophytum procumbens on Freund’s adjuvant-induced arthritis in rats. J. Ethnopharmacol. 2004, 91, 325–330. [Google Scholar] [CrossRef]
- Billingham, M.E.J. Adjuvant arthritis: The first model. In Mechanisms and Models in Rheumatoide Arthritis; Henderson, B., Edwards, J., Pettipher, E., Eds.; Academic Press: Cambridge, MA, USA, 1995; Volume 20, pp. 389–409. [Google Scholar]
- Morris, C.J. Carrageenan-induced paw edema in the rat and mouse. Methods Mol. Biol. 2003, 225, 115–121. [Google Scholar]
- Serrano-Román, J.; del Nicasio-Torres, M.P.; Hernández-Pérez, E.; Jiménez-Ferrer, E. Pharmacokinetic study of anti-osteoarthritic compounds of a standardized fraction from Sphaeralcea angustifolia. Pharmaceuticals 2021, 14, 610. [Google Scholar] [CrossRef]
- Serrano-Román, J.; del Nicasio-Torres, M.P.; Hernández-Pérez, E.; Jiménez-Ferrer, E. Elimination pharmacokinetics of sphaeralcic acid, tomentin and scopoletin mixture from a standardized fraction of Sphaeralcea angustifolia (Cav.) G. Don orally administered. J. Pharm. Biomed. Anal. 2020, 183, 113143. [Google Scholar] [CrossRef] [PubMed]
- Romero-Cerecero, O.; Meckes-Fischer, M.; Zamilpa, A.; Enrique Jiménez-Ferrer, J.; Nicasio-Torres, M.D.P.; Pérez-García, D.; Tortoriello, J. Clinical trial for evaluating the effectiveness and tolerability of topical Sphaeralcea angustifolia treatment in hand osteoarthritis. J. Ethnopharmacol. 2013, 147, 467–473. [Google Scholar] [CrossRef] [PubMed]
- NORMA OFICIAL MEXICANA NOM-059-SEMARNAT-2010 | Procuraduria Federal de Proteccion al Ambiente | Gobierno | gob.mx. Available online: www.gob.mx (accessed on 7 December 2022).
- ÁREAS NATURALES PROTEGIDAS DECRETADAS | Comisión Nacional de Áreas Naturales Protegidas | Gobierno | gob.mx. Available online: www.gob.mx (accessed on 7 December 2022).
- Nicasio-Torres, M.P.; Pérez-Hernández, J.; González-Cortazar, M.; Meckes-Fischer, M.; Tortoriello, J.; Cruz-Sosa, F. Production of potential anti-inflammatory compounds in cell suspension cultures of Sphaeralcea angustifolia (Cav.) G. Don. Acta Physiol. Plant. 2016, 38, 209. [Google Scholar] [CrossRef]
- Pérez-Hernández, J.; Martínez-Trujillo, A.; Nicasio-Torres, P. Optimization of active compounds production by interaction between nitrate and copper in Sphaeralcea angustifolia cell suspension using Response Surface Methodology. Plant Cell. Tissue Organ Cult. 2019, 136, 407–413. [Google Scholar] [CrossRef]
- Pérez-Hernández, J.; del Nicasio-Torres, M.P.; Sarmiento-López, L.G.; Rodríguez-Monroy, M. Production of anti-inflammatory compounds in Sphaeralcea angustifolia cell suspension cultivated in stirred tank bioreactor. Eng. Life Sci. 2019, 19, 196–205. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Díaz, J.L. Usos de las Plantas Medicinales de México. Monografías Científicas II; Instituto Mexicano para el Estudio de las Plantas Medicinales, Ed.; Libros de México: Mexico City, Mexico, 1976; p. 345. [Google Scholar]
- Santana, K.; do Nascimento, L.D.; Lima e Lima, A.; Damasceno, V.; Nahum, C.; Braga, R.C.; Lameira, J. Applications of Virtual Screening in Bioprospecting: Facts, Shifts, and Perspectives to Explore the Chemo-Structural Diversity of Natural Products. Front. Chem. 2021, 9, 662688. [Google Scholar] [CrossRef]
- Harvey, A.L. Natural products in drug discovery. Drug Discov. Today 2008, 13, 894–901. [Google Scholar] [CrossRef]
- Atanasov, A.G.; Waltenberger, B.; Pferschy-Wenzig, E.M.; Linder, T.; Wawrosch, C.; Uhrin, P.; Temml, V.; Wang, L.; Schwaiger, S.; Heiss, E.H.; et al. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnol. Adv. 2015, 33, 1582–1614. [Google Scholar] [CrossRef] [Green Version]
- Newman, D.J.; Cragg, G.M. Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. J. Nat. Prod. 2020, 83, 770–803. [Google Scholar] [CrossRef] [Green Version]
- Calixto, J.B. The role of natural products in modern drug discovery. An. Acad. Bras. Cienc. 2019, 91. [Google Scholar] [CrossRef]
- Newman, D.J.; Cragg, G.M. Natural Products as Sources of New Drugs from 1981 to 2014. J. Nat. Prod. 2016, 79, 629–661. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Romero-Cerecero, O.; Tortoriello-García, J. Conocimiento sobre fitomedicamentos entre médicos del segundo nivel de atención. Rev. Med. Inst. Mex. Seguro Soc. 2007, 45, 453–458. [Google Scholar] [PubMed]
- Sarukhán, J.; Koleff, P.; Carabias Lilo, J.; Soberón, J.; Dirzo, R.; Llorente-Bousquets, J.; Halffter, G.; González, R.; March, I.; Mohar, A.; et al. Evaluación del Conocimiento y Tendencias de Cambio, Perspectivas de Sustentabilidad, Capacidades Humanas e Institucionales; In Capital Natural de México. Com. Nac. para el Conoc. y Uso la Biodivers (CONABIO): Ciudad de México, Mexico, 2017; p. 127.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Meckes-Fischer, M.; Nicasio-Torres, P. The Journey of a Medicinal Plant throughout Science: Sphaeralcea angustifolia (Cav.) G. Don (Malvaceae). Plants 2023, 12, 321. https://doi.org/10.3390/plants12020321
Meckes-Fischer M, Nicasio-Torres P. The Journey of a Medicinal Plant throughout Science: Sphaeralcea angustifolia (Cav.) G. Don (Malvaceae). Plants. 2023; 12(2):321. https://doi.org/10.3390/plants12020321
Chicago/Turabian StyleMeckes-Fischer, Mariana, and Pilar Nicasio-Torres. 2023. "The Journey of a Medicinal Plant throughout Science: Sphaeralcea angustifolia (Cav.) G. Don (Malvaceae)" Plants 12, no. 2: 321. https://doi.org/10.3390/plants12020321