Regulatory Effects of Thai Rice By-Product Extracts from Oryza sativa L. cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition
Abstract
:1. Introduction
2. Results and Discussion
2.1. Extraction Process
2.2. In Vitro Antioxidant Activities
2.3. Cell Viability
2.4. Effects of Oryza sativa L. Extracts on Melanin Production in Melanoma Cells
2.5. Effects of Oryza sativa L. Extracts on Nitric Oxide Production in Macrophages
2.6. Effects of Oryza sativa L. Extracts on Gene Expression of Steroid 5α-Reductase Isoenzymes
3. Materials and Methods
3.1. Chemicals and Reagents
3.2. Plant Materials and Preparation of Sample Extraction
3.3. Antioxidant Activity Assays
3.4. Cell Cultures
3.5. Cytotoxicity Assay
3.6. Melanin Content Assay
3.7. Intracellular Nitric Oxide Production
3.8. RNA Extraction and Semi-Quantitative Reverse Transcription Polymerase Chain Reaction
3.9. Statistical Analysis
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Extracts | DPPH Radical Scavenging Activity (mg TE/g Extract) | ABTS Radical Scavenging Activity (mg TE/g Extract) | Iron Chelating Activity (mg EDTAE/g Extract) |
---|---|---|---|
BB3CMU−RBO | 70.14 ± 0.97 a | 5.45 ± 0.28 a | 28.79 ± 5.63 a |
BB3CMU−DFRB | 147.65 ± 2.05 b | 51.83 ± 2.67 b | 65.47 ± 12.79 a |
BB3CMU−H | 334.70 ± 4.64 c | 196.13 ± 10.09 c | 283.22 ± 55.35 b |
BB4CMU−RBO | 37.05 ± 0.51 d | 3.84 ± 0.20 a | 24.28 ± 4.74 a |
BB4CMU−DFRB | 117.84 ± 1.63 e | 47.03 ± 2.42 b | 71.78 ± 14.03 a |
BB4CMU−H | 198.04 ± 2.75 f | 164.10 ± 8.45 d | 61.12 ± 11.94 a |
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Ruksiriwanich, W.; Linsaenkart, P.; Khantham, C.; Muangsanguan, A.; Sringarm, K.; Jantrawut, P.; Prom-u-thai, C.; Jamjod, S.; Yamuangmorn, S.; Arjin, C.; et al. Regulatory Effects of Thai Rice By-Product Extracts from Oryza sativa L. cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition. Plants 2023, 12, 653. https://doi.org/10.3390/plants12030653
Ruksiriwanich W, Linsaenkart P, Khantham C, Muangsanguan A, Sringarm K, Jantrawut P, Prom-u-thai C, Jamjod S, Yamuangmorn S, Arjin C, et al. Regulatory Effects of Thai Rice By-Product Extracts from Oryza sativa L. cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition. Plants. 2023; 12(3):653. https://doi.org/10.3390/plants12030653
Chicago/Turabian StyleRuksiriwanich, Warintorn, Pichchapa Linsaenkart, Chiranan Khantham, Anurak Muangsanguan, Korawan Sringarm, Pensak Jantrawut, Chanakan Prom-u-thai, Sansanee Jamjod, Supapohn Yamuangmorn, Chaiwat Arjin, and et al. 2023. "Regulatory Effects of Thai Rice By-Product Extracts from Oryza sativa L. cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition" Plants 12, no. 3: 653. https://doi.org/10.3390/plants12030653