Design and Optimization of 3D-Printed Tablets Containing Mucuna Extracts for Erectile Dysfunction Management: A DoE-Guided Study
Abstract
:1. Introduction
2. Results and Discussion
2.1. Screening Factors Affecting Polymer Matrix Formulation Containing Mucuna Extract in 3D Printing
2.2. Levodopa Quantitation
2.3. Formulation Optimization and Release Study
2.4. Excipients and Mucuna Extract Compatibility Study
3. Materials and Methods
3.1. Materials
3.2. Plant Extraction and Preparation
3.3. Screening
3.3.1. Sustained-Release Tablet 3D Printing
3.3.2. Viscosity
3.3.3. Shape Fidelity
3.4. Chromatographic Conditions
3.5. Analytical Method Validation for Levodopa Determination
3.5.1. Specificity
3.5.2. Linearity
3.5.3. Accuracy
3.5.4. Precision
3.6. Optimization
3.6.1. Levodopa Release Study and Drug Release Mechanism Evaluation
3.6.2. Levodopa Content in Mucuna Extract Tablets
3.7. ATR-FTIR
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Formulation | Zero-Order | First-Order | Korsmeyer–Peppas | Higuchi | Hixon–Crowell | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
AIC | R2 | AIC | R2 | AIC | R2 | n | AIC | R2 | AIC | R2 | |
O1 | 29.04 | 0.9757 | 5.78 | 0.9945 | 7.36 | 0.998937 | 0.727987 | 76.81 | 0.9728 | −28.22 | 0.9987 |
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Wattanawiggan, R.; Chansakaow, S.; Jantrawut, P.; Panraksa, P.; Jiaranaikulwanitch, J.; Udomsom, S.; Worajittiphon, P.; Tipduangta, P. Design and Optimization of 3D-Printed Tablets Containing Mucuna Extracts for Erectile Dysfunction Management: A DoE-Guided Study. Plants 2024, 13, 2294. https://doi.org/10.3390/plants13162294
Wattanawiggan R, Chansakaow S, Jantrawut P, Panraksa P, Jiaranaikulwanitch J, Udomsom S, Worajittiphon P, Tipduangta P. Design and Optimization of 3D-Printed Tablets Containing Mucuna Extracts for Erectile Dysfunction Management: A DoE-Guided Study. Plants. 2024; 13(16):2294. https://doi.org/10.3390/plants13162294
Chicago/Turabian StyleWattanawiggan, Ratchapoom, Sunee Chansakaow, Pensak Jantrawut, Pattaraporn Panraksa, Jutamas Jiaranaikulwanitch, Suruk Udomsom, Patnarin Worajittiphon, and Pratchaya Tipduangta. 2024. "Design and Optimization of 3D-Printed Tablets Containing Mucuna Extracts for Erectile Dysfunction Management: A DoE-Guided Study" Plants 13, no. 16: 2294. https://doi.org/10.3390/plants13162294