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Biomedicines
Volume 11
Issue 4
10.3390/biomedicines11041119
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Review
Peer-Review Record

A Comprehensive Review of the Genetic and Epigenetic Contributions to the Development of Fibromyalgia

Biomedicines 2023, 11(4), 1119; https://doi.org/10.3390/biomedicines11041119
by Erik A. Ovrom 1, Karson A. Mostert 2, Shivani Khakhkhar 3, Daniel P. McKee 3, Padao Yang 4 and Yeng F. Her 5,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Biomedicines 2023, 11(4), 1119; https://doi.org/10.3390/biomedicines11041119
Submission received: 14 March 2023 / Revised: 23 March 2023 / Accepted: 28 March 2023 / Published: 7 April 2023
(This article belongs to the Special Issue Advanced Research on Fibromyalgia)

Round 1

Reviewer 1 Report

I read with great interest of the article. The paper is very well-written and well-organization. Besides, this paper increases our knowledge and broad overview about the role of genetic and epigenetic in the development of fibromyalgia.

Minor concerns:

1. A single paragraph to describe the pathophysiology of fibromyalgia should be added in the text.

Author Response

Please see attachment. 

Author Response File: Author Response.docx

Reviewer 2 Report

The authors presented a really comprehensive review related to molecular and genetic aspects of FN development.

However, some issues should be corrected.

Comments

1.      All the typos should be corrected. Line 530: The term “gender” should be used instead of “sex”.

2.      Lines 50-51; 488-489; 523-524; 537-539: These sentences are not clear. They should be clarified.

3.      Lines 494-495 and 273-274: All the repeats should be removed.

4.      Lines 80-103: The review on 5-HT biosynthesis and physiology should be supplemented by schematic presentation(s).

5.      Table 3 title should be modified as the term “other” is not clear.

6.      Lines 318-319 versus line 361: The discrepancy between the levels of IL-6 expression in different studies should be discussed.

7.      Lines 437-438 and line 376; line 452: The downregulated genes should be moved to the next section

8.      Section 3.3 and 3.4: The authors should discuss the possible molecular and cellular mechanisms underlying differential gene expressions in FM.

Author Response

Please see attachment.

Author Response File: Author Response.docx

Reviewer 3 Report

Thank you for the opportunity to review this interesting article. I consider that authors have performed a good and hard job. Congratulations.

I have only two minor concerns:

At first, I would consider to increase the length of introduction.

Secondly, although it was a narrative review, I considert that it is necessary a methods section where appears search strategy and the principal methodological steps to perform the review. 

Author Response

Please see attachment.

Author Response File: Author Response.docx

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