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Toxics, Volume 13, Issue 9

September 2025 - 101 articles

Cover Story: The aim of this study was to treat differentiated human SH-SY5Y cells with Bisphenol S (BPS) and Bisphenol F (BPF) to investigate mechanisms of toxicity. Pathway analysis showed that genes involved in neuroinflammation, protein folding, microglial function, and motor neuron regulation were disrupted, demonstrating that BPS and BPF, even at low, environmentally relevant concentrations, significantly alter gene expression in pathways linked to neuroinflammation, immune signaling, and neurodegenerative diseases. BPS primarily affected ribosomal and immune-related networks, while BPF disrupted oxidative phosphorylation and protein-folding pathways. These alterations suggest mechanisms for long-term neurological effects, highlighting the need for comprehensive evaluations of BPA alternatives. View this paper
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Articles (101)

  • Article
  • Open Access
582 Views
25 Pages

Effects of Long-Term Heavy Metal Pollution on Microbial Community Structure in Soil

  • Qiannuo Mi,
  • Yan Wu,
  • Huaisen Cai,
  • Zuben Xu,
  • Yue Zhao,
  • Ronghao Guan,
  • Xin Fan and
  • Jianhua Guo

22 September 2025

Heavy metal (HM) contamination of soil is a worldwide problem with adverse consequences for the environment and human health. Microorganisms, as the most active fraction in soil, play a pivotal role in assessing changes in soil quality and maintainin...

  • Article
  • Open Access
540 Views
25 Pages

22 September 2025

Cadmium and arsenic co-contamination found in mining actions indicates major effluence in adjacent farmland soils, disturbing the plant physiology and soil’s microbial community. Phosphorus (P) plays a vital role in reducing soil contamination...

  • Article
  • Open Access
479 Views
16 Pages

Characterization and Source Analysis of Water-Soluble Ions in PM2.5 at Hainan: Temporal Variation and Long-Range Transport

  • Xinghong Xu,
  • Wenshuai Xu,
  • Xinxin Meng,
  • Xiaocong Cao,
  • Biwu Chu,
  • Chuandong Du,
  • Rongfu Xie,
  • Zhaohe Zeng,
  • Hui Sheng and
  • Youjing Lin
  • + 2 authors

22 September 2025

We explored the mass concentrations of water-soluble ions in PM2.5 and their variations across different time scales and concentration levels. Using the Positive Matrix Factorization (PMF) model and backward trajectory analysis, we focused on identif...

  • Review
  • Open Access
2 Citations
2,589 Views
41 Pages

22 September 2025

Urban industrialization is a major driver of water pollution, particularly through emerging contaminants that pose significant health risks for humans and ecosystems. This critical review focuses on Bangladesh’s Buriganga and Dhaleshwari rivers...

  • Article
  • Open Access
745 Views
22 Pages

21 September 2025

Microplastic and nanoplastic (MNP) particles have been observed in various human organs. However, polypropylene (PP), one of the top three most commonly detected types of MNPs in terms of quantity, is also present in injections given for the infusion...

  • Article
  • Open Access
553 Views
11 Pages

DEET Metabolite and Hearing Loss in United States Adults

  • Rae T. Benedict,
  • Gregory M. Zarus,
  • Franco Scinicariello,
  • Henry G. Abadin and
  • Roberta Attanasio

20 September 2025

Hearing loss (HL) causes numerous challenges for individuals. N,N-diethyl-meta-toluamide (DEET) is a common ingredient in insect repellants and some sunscreens. M-(diethylcarbamoyl) benzoic acid (DCBA) is a DEET metabolite measured in the urine of Na...

  • Article
  • Open Access
636 Views
23 Pages

20 September 2025

The widespread occurrence of nano-plastics (NPs) in aquatic environments poses emerging challenges to the pollutant removal performance and ecological stability of constructed wetlands (CWs). This study investigates the performance of calcium-modifie...

  • Review
  • Open Access
941 Views
42 Pages

19 September 2025

Thyroid hormone (TH) system disruption by chemicals poses a significant concern due to the key role the TH system plays in essential body functions, including the metabolism, growth, and brain development. Animal-based testing methods are resource-de...

  • Article
  • Open Access
393 Views
19 Pages

Effects of Nitrogen and Phosphorus on Estuarine Phytoplankton Communities in Aquatic Microcosms

  • Jianan Ling,
  • Chao Wei,
  • Dongning Yang,
  • Jiangning Zeng,
  • Fangping Cheng,
  • Xin Zheng and
  • Zhanhong Yang

19 September 2025

Phytoplankton serves as the primary producer in estuarine ecosystems, with its community structure and dynamics being directly influenced by the concentration and ratio of nitrogen (N) and phosphorus (P) nutrients. This study utilized raw water from...

  • Article
  • Open Access
653 Views
16 Pages

The Effect of Radon Concentration on MS Prevalence: A Door-to-Door Survey in the Fault Zone in Afyonkarahisar, Turkey

  • Ülkü Türk Börü,
  • Ahmet Yıldız,
  • Metin Bağcı,
  • Ayla Sandıkçıoğlu Gümüş,
  • Elif Simin Issı,
  • Furkan İncebacak,
  • Hakan Acar and
  • Cem Bölük

19 September 2025

Background: Despite the identification of various environmental factors that increase the risk of multiple sclerosis (MS), the effects of many factors on the etiology of MS remain to be elucidated. In this study, we aimed to investigate the effects o...

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Toxics - ISSN 2305-6304Creative Common CC BY license