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Toxics, Volume 6, Issue 2

2018 June - 15 articles

Cover Story: DNA adducts, the covalent modifications of DNA, are biomarkers and molecular dosimeters reflecting the exposure of genotoxicants. Formalin-fixed paraffin-embedded (FFPE) tissue is an alternative source to the otherwise limited fresh-frozen biopsy samples. FFPE has been widely used in genomics and proteomics, but largely underutilized in DNA adduct analyses. This review covers the formation of DNA adducts, followed by an overview of the formalin fixation process, and the measurement of DNA adducts in FFPE tissues, particularly by liquid chromatography-mass spectrometry. This technology can advance molecular epidemiology studies that seek to assess the causal role of environmental chemicals in cancer etiology. View the paper here.
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Articles (15)

  • Article
  • Open Access
3 Citations
4,062 Views
8 Pages

18 June 2018

The effect of toxic concentrations of La3+ on the Ca, K, Na, Mg, and Cl channels of planaria was investigated through the use of various agonists and antagonists to those channels. It was demonstrated that La exerts its toxic effects through L-type,...

  • Article
  • Open Access
24 Citations
6,370 Views
10 Pages

Cadmium Exposure Disrupts Periodontal Bone in Experimental Animals: Implications for Periodontal Disease in Humans

  • Andrew W. Browar,
  • Emily B. Koufos,
  • Yifan Wei,
  • Landon L. Leavitt,
  • Walter C. Prozialeck and
  • Joshua R. Edwards

13 June 2018

Cadmium (Cd) is an environmental contaminant that damages the kidney, the liver, and bones. Some epidemiological studies showed associations between Cd exposure and periodontal disease. The purpose of this study was to examine the relationship betwee...

  • Feature Paper
  • Article
  • Open Access
21 Citations
6,457 Views
10 Pages

8 June 2018

Fruits and vegetables are considered a beneficial contribution to the human diet. Especially, berries contain a great deal of bioactive compounds, such as anthocyanins, organic acids, tannins, phenols, and antioxidants. Apart from organic substances,...

  • Feature Paper
  • Review
  • Open Access
11 Citations
8,650 Views
20 Pages

1 June 2018

The measurement of DNA adducts provides important information about human exposure to genotoxic chemicals and can be employed to elucidate mechanisms of DNA damage and repair. DNA adducts can serve as biomarkers for interspecies comparisons of the bi...

  • Article
  • Open Access
133 Citations
8,604 Views
20 Pages

26 May 2018

Growing evidences demonstrated that zinc oxide nanoparticles (ZnONPs) could reach the brain after oral ingestion; however, the “neurotoxicity of” ZnONPs after oral exposure has not been fully investigated. This study aimed to explore the...

  • Article
  • Open Access
12 Citations
5,795 Views
12 Pages

14 May 2018

Twelve applications of poultry litter were made to a 2.1-ha field located in the Shenandoah Valley of Virginia, United States (USA), between March 1999 and August 2014. The field was planted with bermudagrass (Cynodon dactylon) and used as a pasture...

  • Article
  • Open Access
25 Citations
5,423 Views
11 Pages

It is essential to understand contaminant exposure and to compare levels of contaminants in organisms at different ages to determine if there is bioaccumulation, and to compare levels encountered in different geographical areas. In this paper, we rep...

  • Feature Paper
  • Article
  • Open Access
23 Citations
7,268 Views
14 Pages

Urinary Cadmium Threshold to Prevent Kidney Disease Development

  • Soisungwan Satarug,
  • Werawan Ruangyuttikarn,
  • Muneko Nishijo and
  • Patricia Ruiz

The frequently observed association between kidney toxicity and long-term cadmium (Cd) exposure has long been dismissed and deemed not to be of clinical relevance. However, Cd exposure has now been associated with increased risk of developing chronic...

  • Review
  • Open Access
51 Citations
10,539 Views
32 Pages

27 April 2018

Carbon tetrachloride (CCl4) is an efficient but highly toxic solvent, used in households and commercially in the industry under regulatory surveillance to ensure safety at the working place and to protect the workers’ health. However, acute uni...

  • Review
  • Open Access
68 Citations
11,087 Views
13 Pages

Herb-Induced Liver Injuries in Developing Nations: An Update

  • Cecilia Nwadiuto Amadi and
  • Orish Ebere Orisakwe

17 April 2018

The last few decades have seen a rise in the use of herbal supplements, natural products, and traditional medicines. However, there are growing concerns related to the safety and toxicities of these medicines. These herbal medicines are associated wi...

  • Feature Paper
  • Article
  • Open Access
22 Citations
5,518 Views
11 Pages

Cancer Mortality in Residents of the Cadmium-Polluted Jinzu River Basin in Toyama, Japan

  • Muneko Nishijo,
  • Hideaki Nakagawa,
  • Yasushi Suwazono,
  • Kazuhiro Nogawa,
  • Masaru Sakurai,
  • Masao Ishizaki and
  • Teruhiko Kido

6 April 2018

After 26 years, we followed up 7348 participants in a 1979–1984 health screening survey in the Jinzu River basin, the heaviest cadmium-polluted area in Japan. We assessed the associations of cadmium exposure levels and mortality from cancer and renal...

  • Article
  • Open Access
42 Citations
6,159 Views
11 Pages

Estimated Dietary Intake of Trace Metals from Swordfish Consumption: A Human Health Problem

  • Grazia Barone,
  • Angela Dambrosio,
  • Arianna Storelli,
  • Rita Garofalo,
  • Vito Pietro Busco and
  • Maria Maddalena Storelli

3 April 2018

Trace element (Hg, Pb, Cd, Zn, Cu, Ni, and Cr) occurrence was determined in the muscle tissue of swordfish collected in the Mediterranean Sea to assess whether the intakes complied with the recommended levels for essential metals and permissible leve...

  • Article
  • Open Access
12 Citations
5,636 Views
13 Pages

29 March 2018

For the majority of lipophilic compounds, adipose tissue is traditionally considered as a storage depot and only rarely as a target organ. Meanwhile, abnormalities in adipose tissue physiology induced by chemical exposure may contribute to the curren...

  • Article
  • Open Access
36 Citations
7,005 Views
15 Pages

22 March 2018

Biomarkers of environmental metal exposure in children are important for elucidating exposure and health risk. While exposure biomarkers for As, Cd, and Pb are relatively well defined, there are not yet well-validated biomarkers of Mn exposure. Here,...

  • Feature Paper
  • Article
  • Open Access
17 Citations
5,156 Views
12 Pages

Mitochondrial Morphology and Function of the Pancreatic β-Cells INS-1 Model upon Chronic Exposure to Sub-Lethal Cadmium Doses

  • Adeline Jacquet,
  • Cécile Cottet-Rousselle,
  • Josiane Arnaud,
  • Kevin Julien Saint Amand,
  • Raoua Ben Messaoud,
  • Marine Lénon,
  • Christine Demeilliers and
  • Jean-Marc Moulis

22 March 2018

The impact of chronic cadmium exposure and slow accumulation on the occurrence and development of diabetes is controversial for human populations. Islets of Langerhans play a prominent role in the etiology of the disease, including by their ability t...

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Toxics - ISSN 2305-6304