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Toxics, Volume 6, Issue 4

2018 December - 15 articles

Cover Story: Methylmercury (MeHg) is a ubiquitous environmental pollutant known to be neurotoxic, particularly during fetal development. However, the mechanisms responsible for prenatal MeHg-induced changes in adult neuronal functions are not yet understood. Our experiments showed that cortical precursor exposed to a sub-nanomolar dose of MeHg led to increased neuronal differentiation, while its proliferation was inhibited. Reduced neuronal differentiation, however, was observed in the higher-dose groups. Our results suggest that sub-nanomolar MeHg exposure may deplete the pool of neural precursors by increasing premature neuronal differentiation, which can lead to long-term neurological effects in adulthood. View this paper.
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Articles (15)

  • Article
  • Open Access
41 Citations
6,725 Views
17 Pages

Chlorpyrifos- and Dichlorvos-Induced Oxidative and Neurogenic Damage Elicits Neuro-Cognitive Deficits and Increases Anxiety-Like Behavior in Wild-Type Rats

  • Aminu Imam,
  • Nafeesah Abdulkareem Sulaiman,
  • Aboyeji Lukuman Oyewole,
  • Samson Chengetanai,
  • Victoria Williams,
  • Musa Iyiola Ajibola,
  • Royhaan Olamide Folarin,
  • Asma’u Shehu Muhammad,
  • Sheu-Tijani Toyin Shittu and
  • Moyosore Salihu Ajao

1 December 2018

The execution of agricultural activities on an industrial scale has led to indiscriminate deposition of toxic xenobiotics, including organophosphates, in the biome. This has led to intoxication characterized by deleterious oxidative and neuronal chan...

  • Article
  • Open Access
15 Citations
4,756 Views
10 Pages

Early, Subclinical Hematological Changes Associated with Occupational Exposure to High Levels of Nitrous Oxide

  • Fatemeh Amiri,
  • Masoud Neghab,
  • Fatemeh Kargar Shouroki,
  • Saeed Yousefinejad and
  • Jafar Hassanzadeh

21 November 2018

This study was undertaken to determine whether exposure of operating room personnel to inhalation anesthetics, nitrous oxide, isoflurane, and sevoflurane was associated with any hematological changes. This historical cohort study was performed in 201...

  • Article
  • Open Access
12 Citations
5,458 Views
14 Pages

Optimization of Sample Preparation for Detection of 10 Phthalates in Non-Alcoholic Beverages in Northern Vietnam

  • Thanh-Thien Tran-Lam,
  • Yen Hai Dao,
  • Duong Thanh Nguyen,
  • Hoi Kim Ma,
  • Trung Quoc Pham and
  • Giang Truong Le

19 November 2018

A novel method was developed for the sensitive, cheap and fast quantitation of 10 phthalates in non-alcoholic beverages by liquid–liquid extraction (LLE) combined with gas chromatography tandem mass spectrometry (GC-MS/MS). The best results wer...

  • Feature Paper
  • Review
  • Open Access
16 Citations
9,730 Views
17 Pages

Impact of Maternal Air Pollution Exposure on Children’s Lung Health: An Indian Perspective

  • Pritam Saha,
  • Ebin Johny,
  • Ashish Dangi,
  • Sopan Shinde,
  • Samuel Brake,
  • Mathew Suji Eapen,
  • Sukhwinder Singh Sohal,
  • VGM Naidu and
  • Pawan Sharma

16 November 2018

Air pollution has become an emerging invisible killer in recent years and is a major cause of morbidity and mortality globally. More than 90% of the world’s children breathe toxic air every day. India is among the top ten most highly polluted c...

  • Article
  • Open Access
6 Citations
6,857 Views
13 Pages

15 November 2018

Studies suggest a relationship between exposure to endocrine disrupters, such as mercury (Hg), and premature puberty. Hg exposure from Thimerosal-containing hepatitis B vaccine, administered at specific intervals within the first six months of life,...

  • Feature Paper
  • Review
  • Open Access
36 Citations
7,095 Views
16 Pages

9 November 2018

Tungsten is a refractory metal that is used in a wide range of applications. It was initially perceived that tungsten was immobile in the environment, supporting tungsten as an alternative for lead and uranium in munition and military applications. R...

  • Review
  • Open Access
271 Citations
24,151 Views
32 Pages

Heavy Metal Mixture Exposure and Effects in Developing Nations: An Update

  • Brilliance Onyinyechi Anyanwu,
  • Anthonet Ndidiamaka Ezejiofor,
  • Zelinjo Nkeiruka Igweze and
  • Orish Ebere Orisakwe

2 November 2018

The drive for development and modernization has come at great cost. Various human activities in developed and developing countries, particularly in sub-Saharan Africa (SSA) have given rise to environmental safety concerns. Increased artisanal mining...

  • Article
  • Open Access
13 Citations
6,301 Views
13 Pages

25 October 2018

The extraction of powdered nutraceuticals is challenging due to the low water content and high concentration of matrix components that can lead to significant matrix effects in liquid chromatography-positive ion electrospray ionization-tandem mass sp...

  • Article
  • Open Access
46 Citations
6,296 Views
13 Pages

The Toxicity Assessment of Iron Oxide (Fe3O4) Nanoparticles on Physical and Biochemical Quality of Rainbow Trout Spermatozoon

  • Mustafa Erkan Özgür,
  • Ahmet Ulu,
  • Sevgi Balcıoğlu,
  • İmren Özcan,
  • Süleyman Köytepe and
  • Burhan Ateş

18 October 2018

The aim of this study was to evaluate the in vitro effect of different doses (50, 100, 200, 400, and 800 mg/L) of Fe3O4 nanoparticles (NPs) at 4 °C for 24 h on the kinematics of rainbow trout (Oncorhynchus mykiss, Walbaum, 1792) spermatozoon. Fir...

  • Article
  • Open Access
17 Citations
5,775 Views
10 Pages

18 October 2018

Among the neurotoxicants contained in tobacco smoke, if absorbed during pregnancy, nicotine significantly affects α7-nicotinic acetylcholine receptors, which play essential roles in the development of the brainstem regions receiving cholinergic...

  • Article
  • Open Access
7 Citations
4,028 Views
10 Pages

10 October 2018

Methylmercury (MeHg) is a ubiquitous environmental pollutant that is known to be neurotoxic, particularly during fetal development. However, the mechanisms responsible for MeHg-induced changes in adult neuronal function, when their exposure occurred...

  • Article
  • Open Access
17 Citations
5,268 Views
10 Pages

Cytotoxicity and Toxicity Evaluation of Xanthone Crude Extract on Hypoxic Human Hepatocellular Carcinoma and Zebrafish (Danio rerio) Embryos

  • Shazrul Fazry,
  • Muhammad Akram Mohd Noordin,
  • Salahuddin Sanusi,
  • Mahanem Mat Noor,
  • Wan Mohd Aizat,
  • Azwan Mat Lazim,
  • Herryawan Ryadi Eziwar Dyari,
  • Nur Hidayah Jamar,
  • Juwairiah Remali and
  • Yi Chieh Lim
  • + 4 authors

9 October 2018

Xanthone is an organic compound mostly found in mangosteen pericarp and widely known for its anti-proliferating effect on cancer cells. In this study, we evaluated the effects of xanthone crude extract (XCE) and α-mangostin (α-MG) on norm...

  • Article
  • Open Access
15 Citations
5,757 Views
12 Pages

2 October 2018

Structural isomeric pesticides are used in agriculture and may be challenging to differentiate for accurate identification in pesticide monitoring programs. Due to structural similarity, isomeric pesticides are difficult to separate chromatographical...

  • Article
  • Open Access
11 Citations
6,399 Views
11 Pages

Pattern of Paracetamol Poisoning: Influence on Outcome and Complications

  • Diego Castanares-Zapatero,
  • Valérie Dinant,
  • Ilaria Ruggiano,
  • Harold Willem,
  • Pierre-François Laterre and
  • Philippe Hantson

29 September 2018

Acute paracetamol poisoning due to a single overdose may be effectively treated by the early administration of N-acetylcysteine (NAC) as an antidote. The prognosis may be different in the case of intoxication due to multiple ingestions or when the an...

  • Article
  • Open Access
6 Citations
4,695 Views
11 Pages

Real-Time Monitoring of Tetraselmis suecica in A Saline Environment as Means of Early Water Pollution Detection

  • Karin Brenda Moejes,
  • Reshma Sulthana Rahiman Sherif,
  • Simone Dürr,
  • Sheelagh Conlan,
  • Alex Mason and
  • Olga Korostynska

28 September 2018

Biological water pollution, including organic pollutants and their possible transportation, via biofouling and ballast water, has the potential to cause severe economic and health impacts on society and environment. Current water pollution monitoring...

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Toxics - ISSN 2305-6304