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Bioengineering, Volume 8, Issue 7

July 2021 - 15 articles

Cover Story: Three-dimensional scaffolding materials, such as electrospun fibers, have been used for in vitro cell cultures with more representative in vivo results. However, the mechanisms of how such a material modulates intracellular activities remain largely unknown. Here, we investigated the roles of a commonly used scaffold in modulating amino acid levels in hepatocytes. Amino acids play a fundamental role in supporting liver functions such as metabolism. We found that the fibrous scaffold generally upregulated the amino acid contents. Further studies revealed that integrin was the bridge between the extracellular and intracellular conditions. These results open new avenues to better understand cell–extracellular matrix interactions. View this paper
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Articles (15)

  • Article
  • Open Access
4 Citations
4,388 Views
18 Pages

De Novo Valve Tissue Morphology Following Bioscaffold Mitral Valve Replacement in a Juvenile Non-Human Primate Model

  • Brittany A. Gonzalez,
  • Marcos Perez Gonzalez,
  • Frank Scholl,
  • Steven Bibevski,
  • Elena Ladich,
  • Jennifer Bibevski,
  • Pablo Morales,
  • Jesus Lopez,
  • Mike Casares and
  • Vincent Brehier
  • + 2 authors

The utility of implanting a bioscaffold mitral valve consisting of porcine small intestinal submucosa (PSIS) in a juvenile baboon model (12 to 14 months old at the time of implant; n = 3) to assess their in vivo tissue remodeling responses was invest...

  • Review
  • Open Access
22 Citations
5,821 Views
26 Pages

Genitourinary Tissue Engineering: Reconstruction and Research Models

  • Christophe Caneparo,
  • David Brownell,
  • Stéphane Chabaud and
  • Stéphane Bolduc

Tissue engineering is an emerging field of research that initially aimed to produce 3D tissues to bypass the lack of adequate tissues for the repair or replacement of deficient organs. The basis of tissue engineering protocols is to create scaffolds,...

  • Review
  • Open Access
34 Citations
7,230 Views
27 Pages

COVID-19 Biomarkers and Advanced Sensing Technologies for Point-of-Care (POC) Diagnosis

  • Ernst Emmanuel Etienne,
  • Bharath Babu Nunna,
  • Niladri Talukder,
  • Yudong Wang and
  • Eon Soo Lee

COVID-19, also known as SARS-CoV-2 is a novel, respiratory virus currently plaguing humanity. Genetically, at its core, it is a single-strand positive-sense RNA virus. It is a beta-type Coronavirus and is distinct in its structure and binding mechani...

  • Article
  • Open Access
23 Citations
5,246 Views
14 Pages

3D Printed Nanocellulose Scaffolds as a Cancer Cell Culture Model System

  • Jennifer Rosendahl,
  • Andreas Svanström,
  • Mattias Berglin,
  • Sarunas Petronis,
  • Yalda Bogestål,
  • Patrik Stenlund,
  • Simon Standoft,
  • Anders Ståhlberg,
  • Göran Landberg and
  • Gary Chinga-Carrasco
  • + 1 author

Current conventional cancer drug screening models based on two-dimensional (2D) cell culture have several flaws and there is a large need of more in vivo mimicking preclinical drug screening platforms. The microenvironment is crucial for the cells to...

  • Review
  • Open Access
27 Citations
9,414 Views
22 Pages

Human mesenchymal stem cells (hMSCs) have demonstrated great potential to be used as therapies for many types of diseases. Due to their immunoprivileged status, allogeneic hMSCs therapies are particularly attractive options and methodologies to impro...

  • Article
  • Open Access
5 Citations
3,662 Views
14 Pages

The use of video and music as an intrinsic, dissociative attentional stimulus during exercise is thought to distract from the physical discomfort of exercise, and contribute to improved exercise adherence; however, the effects of video-based feedback...

  • Review
  • Open Access
35 Citations
14,656 Views
20 Pages

Blood Plasma Self-Separation Technologies during the Self-Driven Flow in Microfluidic Platforms

  • Yudong Wang,
  • Bharath Babu Nunna,
  • Niladri Talukder,
  • Ernst Emmanuel Etienne and
  • Eon Soo Lee

Blood plasma is the most commonly used biofluid in disease diagnostic and biomedical analysis due to it contains various biomarkers. The majority of the blood plasma separation is still handled with centrifugation, which is off-chip and time-consumin...

  • Review
  • Open Access
153 Citations
25,004 Views
29 Pages

Pesticides are chemical compounds used to eliminate pests; among them, herbicides are compounds particularly toxic to weeds, and this property is exploited to protect the crops from unwanted plants. Pesticides are used to protect and maximize the yie...

  • Article
  • Open Access
2 Citations
3,431 Views
16 Pages

In the field of cell therapy, the interest in cell sheet technology is increasing. To determine the cell sheet harvesting time requires experience and practice, and different factors could change the harvesting time (variability among donors and cult...

  • Article
  • Open Access
25 Citations
3,679 Views
12 Pages

Transcatheter Heart Valve Implantation in Bicuspid Patients with Self-Expanding Device

  • Salvatore Pasta,
  • Stefano Cannata,
  • Giovanni Gentile,
  • Valentina Agnese,
  • Giuseppe Maria Raffa,
  • Michele Pilato and
  • Caterina Gandolfo

Bicuspid aortic valve (BAV) patients are conventionally not treated by transcathether aortic valve implantation (TAVI) because of anatomic constraint with unfavorable outcome. Patient-specific numerical simulation of TAVI in BAV may predict important...

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Bioengineering - ISSN 2306-5354