Microbial Matryoshka: Addressing the Relationship between Pathogenic Flagellated Protozoans and Their RNA Viral Endosymbionts (Family Totiviridae)
Abstract
:Simple Summary
Abstract
1. Introduction
2. Totiviridae Family: Viral and Genomic Structure, Cycle, and Other Details
3. Flagellated Protozoans of Health Relevance
3.1. Giardia-Giardiavirus
3.1.1. Endosymbiotic Relationship
3.1.2. Endosymbiotic Modulation of Virulence and Immune Response
3.2. Trichomonas-Trichomonasvirus
3.2.1. Endosymbiotic Relationship
3.2.2. Endosymbiont Modulation of Virulence and Immune Response
3.3. Leishmania-Leishmaniavirus
3.3.1. Endosymbiotic Relationship
3.3.2. Endosymbiont Modulation of Virulence and Immune Response
3.4. Trypanosoma and Other Suspected VLPs
4. Concluding Remarks and Future Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
LPG | Lipophosphoglycan |
iNOS | Inducible nitric oxide synthase |
NO | Nitric oxide |
ROS | Reactive oxygen species |
TLR | Toll-like receptor |
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Country | Type of Sample | TVV Presence | TVV Type Isolates | Co-Infections % (n) * | Ref. |
---|---|---|---|---|---|
Austria, Brazil, China, Czech Republic, Estonia, Slovakia, Sweden, and USA | NR | 44.4% (8/18) | NR | NR | [93] |
Australia, Chile, India, Italy, Mexico, Papua New Guinea, Southern Africa, and USA | Vaginal swabs | 30.3% (67/221) | NR | NR | [94] |
Czech Rep., Slovakia, USA, China, Brazil, Estonia, Sweden, and Austria | Vaginal samples + 3 ATCC isolates | 40% (8/20) | NR | NR | [95] |
Brazil | Urine samples + 2 ATCC isolates | 90.9% (30/33) | TVV1 = 24 TVV2 = 9 TVV3 = 11 TVV4 = 3 | 36.7% (11/30) | [96] |
Cuba | Vaginal samples | 55% (22/40) | NR | NR | [97] |
Cuba | Vaginal exudates | 55% (22/40) | NR | NR | [98] |
Cuba | NR | 56.7% (21/37) | TVV1 = 19 TVV2 = 15 | 14.3% (3/21) | [99] |
Cuba | Vaginal samples | 100% (3/3) | TVV1 = 1 TVV2 = 2 | NR | [100] |
Egypt | Vaginal swabs | 35% (7/20) | NR | NR | [101] |
Egypt | Vaginal swabs | 20% (8/40) | TVV2 = 5 TVV4 = 3 | 0% (0/8) | [102] |
India | Vaginal swabs and urine samples | 100% (30/30) | NR | NR | [86] |
Italy | NR | 50% (24/48) | TVV1 = 17 TVV2 = 19 TVV3 = 13 TVV4 = 2 | 75% (18/24) | [103] |
Iran | Vaginal discharge and urine samples | 17.4% (8/46) | TVV1 = 8 | NR | [104] |
Iran | Vaginal swabs | 50% (4/8) | TVV1 = 4 | 0% (0/4) | [105] |
Iran | Vaginal samples | 44.4% (4/9) | TVV1 = 4 TVV2 = 1 TVV3 = 1 | 25% (1/4) | [106] |
Kenya | Vaginal swabs | 43.5% (10/22) | TVV1 = 9 TVV2 = 6 TVV3 = 4 TVV4 = 3 | 90% (9/10) | [107] |
Korea | NR | 14% (4/22) | NR | NR | [85] |
Netherlands | Cervicovaginal + urine samples | 50.4% (60/119) | TVV1 = 42 TVV2 = 26 TVV3 = 34 | 51.7% (31/60) | [92] |
Philippines | Vaginal swabs | 18.7% (18/96) | TVV1 = 12 TVV2 = 12 TVV3 = 5 TVV4 = 6 | 33.3% (6/18) | [108] |
Philippines | Vaginal swabs | 30.9% (13/42) | NR | NR | [109] |
Turkey | Vaginal swabs | 16.7% (5/30) | NR | NR | [110] |
South Africa | Clinical samples | 81.9% (59/72) | NR | NR | [111] |
USA | NR | 50% (14/28) | NR | NR | [112] |
USA | Vaginal swabs and clinical samples | 50% (55/109) | NR | NR | [113] |
USA | Vaginal swabs and urine samples | 75% (21/28) | NR | NR | [114] |
USA | Vaginal swabs | 40% (142/355) | NR | NR | [28] |
USA | Vaginal swabs | 100% (5/5) | TVV1 = 5 TVV2 = 3 TVV3 = 3 TVV4 = 4 | 100% (5/5) | [90] |
USA | Vaginal swabs | 81.2% (13/16) | NR | 84.6% (11/13) | [12] |
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Ibañez-Escribano, A.; Gomez-Muñoz, M.T.; Mateo, M.; Fonseca-Berzal, C.; Gomez-Lucia, E.; Perez, R.G.; Alunda, J.M.; Carrion, J. Microbial Matryoshka: Addressing the Relationship between Pathogenic Flagellated Protozoans and Their RNA Viral Endosymbionts (Family Totiviridae). Vet. Sci. 2024, 11, 321. https://doi.org/10.3390/vetsci11070321
Ibañez-Escribano A, Gomez-Muñoz MT, Mateo M, Fonseca-Berzal C, Gomez-Lucia E, Perez RG, Alunda JM, Carrion J. Microbial Matryoshka: Addressing the Relationship between Pathogenic Flagellated Protozoans and Their RNA Viral Endosymbionts (Family Totiviridae). Veterinary Sciences. 2024; 11(7):321. https://doi.org/10.3390/vetsci11070321
Chicago/Turabian StyleIbañez-Escribano, Alexandra, Maria Teresa Gomez-Muñoz, Marta Mateo, Cristina Fonseca-Berzal, Esperanza Gomez-Lucia, Raquel Garcia Perez, Jose M. Alunda, and Javier Carrion. 2024. "Microbial Matryoshka: Addressing the Relationship between Pathogenic Flagellated Protozoans and Their RNA Viral Endosymbionts (Family Totiviridae)" Veterinary Sciences 11, no. 7: 321. https://doi.org/10.3390/vetsci11070321
APA StyleIbañez-Escribano, A., Gomez-Muñoz, M. T., Mateo, M., Fonseca-Berzal, C., Gomez-Lucia, E., Perez, R. G., Alunda, J. M., & Carrion, J. (2024). Microbial Matryoshka: Addressing the Relationship between Pathogenic Flagellated Protozoans and Their RNA Viral Endosymbionts (Family Totiviridae). Veterinary Sciences, 11(7), 321. https://doi.org/10.3390/vetsci11070321