Proceedings, Volume 40, Issue 1

The Southeast Asian mangosteen (Garcinia mangostana) contains a class of phytochemicals known as xanthones that possess extensive biological activity. Applications of xanthones, including the most prominent, alpha-mangostin, have been shown to posses...

Bimetallic nanoparticles (NP) have improved properties such as antimicrobial, anticancer and photocatalytic activity due to the synergistic effects of their components. Unmet needs of the current cancer treatments encourage researchers for the new tr...

Botanical compounds have been found to modulate genetic and epigenetic pathways of cancer development and progression. We have studied nutritional interventions, with emphasis on soy isoflavones. Preclinical and clinical translational research have b...

Enzyme has been unique properties due to superior catalytic. [...]

N-type calcium channels (Neuronal-type Calcium channel, Cav2.2) is a member of high voltage activated calcium channels. There are two native small peptides for N-type calcium channels (NTCC) directly which are derived from cone snail, ω-conotox...

Cancer is one of the top two causes of deaths in the US and the world. Cancer therapy includes standard therapies such as surgery, chemotherapy and targeted therapies, by antibody and small molecule inhibitors, and immunotherapy (i.e., check point in...

The role of RNA-dependent protein kinase R (PKR) and its association with misfolded protein expression in cancer cells are unclear. Herein we report that PKR regulates misfolded protein clearance by preventing it release through exosomes and promotin...

The engineering of convenient three-dimensional (3D) in vitro tumor models presents many challenges, but they are increasingly identifying as one of the best preclinical drug-screening platforms and a developed method to research cancer in controlled...

The genus Achillea L. belongs to Asteraceae (Compositae), the largest family of vascular plants. There are 50 species, which of 24 is endemic in this genus in Turkey. Achillae species are used as a tonic, anti-inflammatory, anti-spasmodic, diaphoreti...

Prostate cancer is the second common cause of death among men worldwide. In the treatment of prostate cancer, conventional chemotherapeutics are commonly used. The plant alkaloid Paclitaxel and platinum-based cisplatin are the most common chemotherap...

Natural products are important in prevention and treatment of cancer because of their antitumor effect and reducing side effects of chemotherapeutic drugs. The aim of this study was to investigate the potential cytotoxic effecs of carnosic acid and i...

The natural products obtained from plants, bacteria, fungi and marine have been used in the treatment of human diseases throughout the centuries. These compounds of them also interfere with the expression of genes by influencing epigenetic mechanisms...

Prostate cancer is one of the cause of mortality and morbidity in men. High nutritional quality mushrooms have been consumed as food for a long time and Thanks to their bioactive components, they can be used in many fields such as pharmaceuticals, co...

Cancer is one of the major causes of death globally, which involves uncontrollable growth and spread of abnormal cells. Cytotoxic plant extracts may act on various cancer cells. In this study cytotoxicity of five cultivated Asteraceae plant extracts...

Finding for more effective anticancer drugs on almost different types of cancer, a huge number of molecules is still under evaluation and barely many more than 100,000 compounds have been tested with researchers and several institutions since recent...

Wolfberry (Lycium barbarum) shows strengthen immune system, antioxidant and anticancerogenic effect. In this research, the effects of Wolfberry's extract fractions, cultivated in Kayseri, investigated on Ehrlich ascites tumor (EAT) using in vivo and...

Phlomis is a large genus in the Lamiaceae family with over 100 species distributed throughout Europe, Asia and North Africa. Some species of Phlomis are used in folk medicine as a stimulant, tonic, and for wound healing. Many studies have shown that...

Conventional medicine focuses mostly on the diagnosis and treatment of disease which is the acute localized problem in healthy body. On the other hand, chronic diseases are functional disorders in physiological processes. Therapeutic goal is not to t...

Glioblastoma multiforme (GBM) is a type of cancer which has the highest mortality rate among brain cancers (1–2). Momordica charantia, known as bitter melon, is a plant its pharmacological activities and nutritional properties. Due to contains bioact...

Glioblastoma (GB) is the most aggressive form of brain tumor and resistant to chemotherapy. New therapeutic approaches are needed to improve the efficacy of chemotherapy. It was reported that there may be a relationship between obesity and poor progn...

The genus Scorzonera has great potential as traditional drugs and foods in several traditional systems including Turkey. In this current work, we investigated antioxidant properties of different extracts from S. hieraciifolia aerial parts and roots....

Bersama abyssinica, belonging to the Melianthaceae family, is distributed across Sub Saharan Africa. Decoctions of the bark, leaves, and roots of B. abyssinica have been extensively used in traditional medicine to manage many stomach complications su...

Glioblastoma (GB) is the most lethal brain tumor that resists standard treatments because of its high malignancy. Radiotherapy (RT) directly affects the clinical success on GB treatment. Epigenetic modifications occur in GB cells at a high rate. Impr...

Nowadays, knowledge of ancient botanical medicinal practices and application of modern phytochemical techniques have provided the excellent tools for the purification and structural elucidation of various phyto-compounds, which, in turn, has given in...

The genus Sideritis, belonging to the Labiateae family, is represented by more than 150 species distributed mainly in the Mediterranean regions. Member of the genus have been used as beverages, flavorings, and medication. We aimed to shed light on th...

The main energy source of cancer cells is known as glucose. However, they use glutamine as a second energy source besides glucose. In this study we investigated effect of siRNA mediated inhibition of glutaminase (GLS1) enzyme in the first step of glu...

Cancer is one of the most debilitating and traumatic diseases of modern life, for which no curative approach is presently available. Even though the recent therapies used to treat patients with various types of cancer have not been completely effecti...

Resveratrol, a natural product, has many biological effects including antitumor effects. Paclitaxel, a chemotherapeutic drug, has been widely used in the treatment of lung cancer. Although the antitumor effects of resveratrol and paclitaxel in A549 c...

Glioblastoma multiforme is one of the most common and aggressive brain tumors. It is mortal and progressive disease despite novel therapies. The mechanism of action of temozolomide (TMZ) is the methylation of DNA guanin at position N7 and O6. This si...

Recently, different herbal compounds have been studied for their curative properties against Hepatocellular Carcinoma (HCC). There are over 100 Phlomis species native to the Mediterranean region, which have pharmacological activities against gastroin...

Encephalitozoon intestinalis (E. intestinalis) is a parasite that causes opportunistic infections that can cause death in immune compromised patients. The aim of this study was to determine the effect of parasite on genes involved in host cell apopto...

The Arum L. in the Araceae family belongs to flowering plants. It is represented by 14 species and four varieties. In total, there are 18 taxa in Turkey. Arum rupicola Boiss. var. rupicola is one of taxa among them. Traditionally, boiled and dried le...

Herbal medicines are complementary and alternative medicine that is used not only in the treatment of cancer and cancer-related conditions, but also to improve the side effects of anticancer therapies. The use of so‐called alternative medicine has in...

The genus Teucrium belonging to the Lamiaceae family, grows in the Eastern Mediterranean region from Turkey to Palestine. Teucrium divaricatum Kotschy ssp. canescens (Celak.) is an endemic plant in North Cyprus. Herbal parts of Teucrium is used as an...

Herbal medicines consist of many different type of active ingredients obtained from medicinal plants. The amounts of compounds may be changeable with the environmental, harvesting, draying, storage conditions and process of production as well. In the...

The mechanisms underlying the growth inhibitory effect of resveratrol on Ph+ ALL cells were investigated with regard to targeting of ceramide metabolism and changes in BCR-ABL expression. Growth inhibition and apoptotic effects of resveratrol, SK inh...

Sphingolipids are important signaling lipids which play crucial roles to determine the cell fate. Ceramide, apoptotic central molecule of sphingolipid metabolism, which is produced through de novo pathway by serine palmitoyl transferase (SPT) and can...

Viburnum L., is one of the most diverse genera of Caprifoliaceae family. There are 4 species of this genus in Turkey. One of them is Viburnum opulus L. The fruits of V. opulus have been used as an antidiabetic in Turkish folk medicine and a tradition...

Angiogenesis is important process that play active role in tumorigenesis. VEGFR-1, a member of the tyrosine kinase receptor family, is known as the receptor for VEGF ligands in tumor cells. SPARC protein has recently been shown to play a role in meta...

Kynurenic Acid (KYNA) is a metabolite of tryptophan pathway and also an endogenous antagonist of glutamate receptors. Several studies indicated that glutamate antagonists have anti-proliferative potential. Moreover, subunits of the NMDA receptor whic...

Many plants with high antioxidant activity are great of significant in the pharmaceutical and cosmetic industries. Oxidative stress plays a major part in the development of many diseases including cancer, which is known imbalance free radicals and an...

Origanum majorana (OM) L. belongs to Lamiaceae family and has antiinflammatory effects. The common feature of the causes of lung cancer is the coexistence of inflammatory events. The aim of this study was to investigate the anti-inflammatory activity...

Breast cancer is the most common cancer in women worldwide and the second most common cancer overall. Autocrine growth hormone (GH) expression induced cell proliferation, growth, invasion-metastasis in vitro and in vivo breast cancer models. Moreover...

Pancreatic cancer is a lethal disease for which the incidence and mortality rates are close. Patients with advanced stage have median survival of three months. Gemcitabine (GEM), the anticancer analog of deoxycytidine, has been considered standard ca...

Early diagnosis is very strategic for today’s diseases such as cancer and infectious diseases. [...]

Breast cancer is identified as the most common cancer among women and the leading cause of cancer-related deaths. Increased expression of growth hormone (GH) has been found to cause cell growth, drug resistance and invasion-metastasis in breast cance...

Pancreatic cancer is the fourth most common cause of cancer death worldwide with limited therapeutic potential and low survival rate. A natural agent; triptolide (diterpenoid triepoxide), induce cell viability loss, growth inhibition and apoptotic ce...

The most common primary liver malignancy is hepatocellular carcinoma. Various chemotherapy drugs are used for treatment. These drugs have high toxicity to liver tissue. More effective, less toxic options should be preferred for treatment. The aim of...

Multiple Sclerosis (MS) is a chronic inflammatory, demyelinating neurodegenerative disease targeting the central nervous system. The pathogenesis of MS is a process of innate and adaptive immune system components. In particular, Th17 and Treg balance...

Multiple Sclerosis (MS) is a chronic inflammatory, demyelinating neurodegenerative disease targeting the central nervous system. The pathogenesis of MS is an immune mediated process involving innate and adaptive immune system components. In particula...