Abstract
Stunting is a major public health problem in low- and middle-income countries because of its association with increased risk of mortality during childhood. To investigate whether zinc deficiency and insulin-like growth factor I are associated with the prevalence of stunting among school-aged children, a cross-sectional study was conducted in which 141 pupils from the first grade were recruited through a multistage cluster sampling technique. The blood sample was drawn from the pupils to analyze zinc, insulin-like growth factor (IGF-1), hemoglobin (HG), albumin, and C-reactive protein (CRP). Height, weight, and body mass index (BMI) were measured whereas height for age Z-score was computed to assess stunting. The study revealed that the prevalence of stunting among the study population is 34% out of which 27.7% and 6.4% exhibit mild and moderate stunting, respectively. The prevalence of zinc deficiency is almost 5% among the pupils. There is a positive association between serum zinc and IGF-1 (p = 0.013), and the results of the Multiple Linear Regression (MLR) illustrate that as the serum zinc level increases by one unit, the IGF-1 level increases by 0.61 cm. In addition, the final model of the MLR analysis shows a negative correlation between being female and height. By investigating the direction of the association between age and IGF-1 and height, it was clear that a positive correlation exists (b = 0.20, 0.03), respectively. This study shows a higher rate of stunting among first-grade children in the Gaza Strip and might be attributed to many factors such as gender, age, household size, and IGF-1.
Author Contributions
Conceptualization, E.E. and I.A.N.; methodology, E.E.; validation, E.E., I.A.N. and I.M.A.; formal analysis, E.E.; investigation, E.E.; data curation, E.E.; writing—original draft preparation, E.E.; writing—review and editing, E.E.; visualization, I.A.N.; supervision, I.A.N. and I.M.A.; project administration, E.E.; funding acquisition, E.E. All authors have read and agreed to the published version of the manuscript.
Funding
This research received no external funding.
Institutional Review Board Statement
The study was conducted in accordance with the Declaration of Helsinki, and approved by the Institutional Review Board of name of the Palestinian Health Research Council, Helsinki committee for Ethical Approval No: PHRC/HC/359/18.
Informed Consent Statement
Informed consent was obtained from all subjects involved in the study.
Data Availability Statement
https://www.alazhar.edu.ps/library/allarchive.asp (accessed on 22 October 2020).
Conflicts of Interest
The authors declare no conflict of interest.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).