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  • Clinical and Translational Neuroscience is published by MDPI from Volume 5 Issue 2 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with SAGE.

Clinical and Translational Neuroscience, Volume 5, Issue 1

2021 April - 10 articles

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Articles (10)

  • Article
  • Open Access
1 Citations
1,666 Views
7 Pages

Factors Associated with Early Reperfusion Improvement after Intra-Arterial Fibrinolytics as Rescue for Mechanical Thrombectomy

  • Johannes Kaesmacher,
  • Giovanni Peschi,
  • Nuran Abdullayev,
  • Basel Maamari,
  • Tomas Dobrocky,
  • Jan Vynckier,
  • Eike Piechowiak,
  • Raoul Pop,
  • Daniel Behme and
  • Urs Fischer
  • + 24 authors

Objective: To identify factors associated with early angiographic reperfusion improvement (EARI) following intra-arterial fibrinolytics (IAF) after failed or incomplete mechanical thrombectomy (MT). Methods: A subset of patients treated with MT and I...

  • Case Report
  • Open Access
1 Citations
1,672 Views
4 Pages

Stroke and Splenic Infarct in a 17-Year-Old Patient with COVID-Associated Hypercoagulable State and Relative ADAMTS13 Deficiency

  • Maximilian Pistor,
  • Angelika Hoffmann,
  • Thomas Horvath,
  • Michael Oberholzer,
  • Marcel Arnold and
  • Sara Magdalena Pilgram-Pastor

In this case report, we present the case of a 17-year-old stroke patient suffering from coronavirus disease (COVID)-19. He was successfully treated with intravenous and endovascular treatment. After extensive work-up, a hypercoagulable state due to t...

  • Review
  • Open Access
1,432 Views
7 Pages

Myocardial Injury in Acute Ischemic Stroke

  • Christian H Nolte,
  • Matthias Endres and
  • Jan F Scheitz

Since antiquity, the interaction of brain and heart has inspired physicians and philosophers. Today, our knowledge has vastly improved, but the exact way of their interaction still holds many secrets to reveal. The interaction between brain and heart...

  • Review
  • Open Access
3 Citations
1,394 Views
12 Pages

Imaging of Nonatheromatous Carotid Artery Disease

  • Daniel Montes and
  • Javier M Romero

Imaging diagnosis of nonatheromatous carotid artery disease is challenging due to its low prevalence in contrast to that of atheromatous disease. Congenital anomalies are frequently discovered incidentally, as the chronicity of these conditions allow...

  • Review
  • Open Access
2 Citations
1,417 Views
8 Pages

Stroke in Women: Is It Different?

  • Sydney Corbière and
  • Barbara Tettenborn

In the last decades, there has been great progress in the field of stroke. With the introduction of acute therapies (intravenous thrombolysis and intra-arterial treatment), the outcome after stroke has improved significantly. Better prevention, impro...

  • Guidelines
  • Open Access
7 Citations
1,712 Views
11 Pages

Acute Revascularization in Ischemic Stroke: Updated Swiss Guidelines

  • Patrik Michel,
  • Michael Diepers,
  • Pasquale Mordasini,
  • Tilman Schubert,
  • David Bervini,
  • Jean-Daniel Rouvé,
  • Yvan Gasche,
  • Guido Schwegler,
  • Christophe Bonvin and
  • on behalf of the Swiss Stroke Society
  • + 10 authors

In acute ischemic stroke, intravenous thrombolysis (IVT) and acute endovascular therapy (EVT) have been shown to reduce long-term disability in randomized trials. International guidelines are partially not up to date and may not address situations fo...

  • Systematic Review
  • Open Access
4 Citations
2,199 Views
8 Pages

Background: Carotid artery stenosis is an important cause for stroke. Carotid endarterectomy (CEA) reduces the risk of stroke in patients with symptomatic carotid stenosis and to some extent in patients with asymptomatic carotid stenosis. More than 2...

  • Review
  • Open Access
12 Citations
1,620 Views
7 Pages

Current treatment for acute ischemic stroke aims at recanalizing the occluded blood vessel to reperfuse ischemic brain tissue. Clot removal can be achieved pharmacologically with a thrombolytic drug, such as recombinant tissue plasminogen activator,...

  • Guidelines
  • Open Access
1,441 Views
8 Pages

Swiss Guidelines for the Prehospital Phase in Suspected Acute Stroke

  • Georg Kägi,
  • David Schurter,
  • Julien Niederhäuser,
  • Gian Marco De Marchis,
  • Stefan Engelter,
  • Patrick Arni,
  • Olivier Nyenhuis,
  • Paul Imboden,
  • Christophe Bonvin and
  • Patrik Michel
  • + 7 authors

Acute stroke treatment has advanced substantially over the last years. Important milestones constitute intravenous thrombolysis, endovascular therapy (EVT), and treatment of stroke patients in dedicated units (stroke units). At present in Switzerland...

  • Perspective
  • Open Access
1,154 Views
4 Pages

Despite a difficult year focusing on the COVID-19 pandemic, from 7 November to 8 November, stroke clinicians and researchers experienced a great opportunity to learn about the latest research results and developments across the entire care spectrum....

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Clin. Transl. Neurosci. - ISSN 2514-183X