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High-Throughput, Volume 7, Issue 3

2018 September - 10 articles

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Articles (10)

  • Review
  • Open Access
19 Citations
12,058 Views
12 Pages

The Cytoscan HD Array in the Diagnosis of Neurodevelopmental Disorders

  • Francesca Scionti,
  • Maria Teresa Di Martino,
  • Licia Pensabene,
  • Valentina Bruni and
  • Daniela Concolino

14 September 2018

Submicroscopic chromosomal copy number variations (CNVs), such as deletions and duplications, account for about 15–20% of patients affected with developmental delay, intellectual disability, multiple congenital anomalies, and autism spectrum di...

  • Article
  • Open Access
6 Citations
4,368 Views
15 Pages

Transcriptional Identification of Related Proteins in the Immune System of the Crayfish Procambarus clarkii

  • Gabina Calderón-Rosete,
  • Juan Antonio González-Barrios,
  • Manuel Lara-Lozano,
  • Celia Piña-Leyva and
  • Leonardo Rodríguez-Sosa

12 September 2018

The freshwater crayfish Procambarus clarkii is an animal model employed for physiological and immunological studies and is also of great economic importance in aquaculture. Although it is a species of easy husbandry, a high percentage of its producti...

  • Review
  • Open Access
15 Citations
4,932 Views
17 Pages

12 September 2018

Proteomics has become one of the most important disciplines for characterizing cellular protein composition, building functional linkages between protein molecules, and providing insight into the mechanisms of biological processes in a high-throughpu...

  • Feature Paper
  • Article
  • Open Access
10 Citations
4,431 Views
14 Pages

4 September 2018

The present study aimed at determining the histamine production capacity of Gram (+) and Gram (−) bacteria isolated from Octopus maya, along with identifying the presence of amino acid decarboxylase genes. Of the total 80 psychrotrophic microor...

  • Feature Paper
  • Article
  • Open Access
26 Citations
7,466 Views
13 Pages

p-Value Histograms: Inference and Diagnostics

  • Patrick Breheny,
  • Arnold Stromberg and
  • Joshua Lambert

31 August 2018

It is increasingly common for experiments in biology and medicine to involve large numbers of hypothesis tests. A natural graphical method for visualizing these tests is to construct a histogram from the p-values of these tests. In this article, we e...

  • Feature Paper
  • Review
  • Open Access
76 Citations
12,259 Views
8 Pages

Oral Biofilms: Development, Control, and Analysis

  • Daniela Berger,
  • Aviva Rakhamimova,
  • Andrew Pollack and
  • Zvi Loewy

31 August 2018

The oral cavity harbors hundreds of microbial species that are present either as planktonic cells or incorporated into biofilms. The majority of the oral microbes are commensal organisms. Those that are pathogenic microbes can result in oral infectio...

  • Feature Paper
  • Article
  • Open Access
1 Citations
3,363 Views
6 Pages

New Developments in the Synthesis of EMICORON

  • Massimo Pitorri,
  • Marco Franceschin,
  • Ilaria Serafini,
  • Alessandro Ciccòla,
  • Claudio Frezza and
  • Armandodoriano Bianco

29 August 2018

This paper reports on the modification of two synthetic steps in the usual protocol used for obtaining EMICORON. EMICORON is a benzo[ghi]perylen-diimide, which was synthesized for the first time in our laboratory in 2012, and has shown to have in viv...

  • Feature Paper
  • Article
  • Open Access
5 Citations
5,125 Views
16 Pages

Conformational Design and Characterisation of a Truncated Diamine Oxidase from Arthrobacter globiformis

  • Nur Nadia Razali,
  • Nur Hafizah Hashim,
  • Adam Thean Chor Leow and
  • Abu Bakar Salleh

25 August 2018

A functional mini protein can be developed by miniaturising its size. The minimisation technique provides an excellent model system for studying native enzymes, especially in creating an alternative novel biocatalyst. Miniaturised proteins may have e...

  • Review
  • Open Access
37 Citations
9,502 Views
23 Pages

Genomics and Epigenetics of Malignant Mesothelioma

  • Adam P. Sage,
  • Victor D. Martinez,
  • Brenda C. Minatel,
  • Michelle E. Pewarchuk,
  • Erin A. Marshall,
  • Gavin M. MacAulay,
  • Roland Hubaux,
  • Dustin D. Pearson,
  • Aaron A. Goodarzi and
  • Wan L. Lam
  • + 1 author

Malignant mesothelioma is an aggressive and lethal asbestos-related disease. Diagnosis of malignant mesothelioma is particularly challenging and is further complicated by the lack of disease subtype-specific markers. As a result, it is especially dif...

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High-Throughput - ISSN 2571-5135