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BioMedInformatics, Volume 5, Issue 3

2025 September - 23 articles

Cover Story: Medical image classification has become essential for automated disease detection, particularly in gastrointestinal endoscopy where accurate diagnosis impacts patient outcomes. Traditional deep learning approaches, while effective, face computational constraints in clinical deployment. Quantum machine learning offers potential solutions thanks to quantum properties like superposition and entanglement for enhanced computational efficiency. This study introduces the Fused Quantum Dual-Backbone Network, a hybrid framework designed for NISQ-era hardware. Experimental validation demonstrated 95.42% accuracy with 94.44% reduction in trainable parameters versus classical methods. These results indicate that quantum-enhanced architectures can address computational limitations while maintaining diagnostic accuracy for clinical applications. View this paper
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Articles (23)

  • Article
  • Open Access
1,321 Views
15 Pages

Background: The selection of machine learning (ML) models in the biomedical sciences often relies on global performance metrics. When these metrics are closely clustered among candidate models, identifying the most suitable model for real-world deplo...

  • Article
  • Open Access
1,846 Views
21 Pages

This paper investigates the state of substance use disorder (SUD) and the frequency of substance use by utilizing three unsupervised machine learning techniques, based on the Diagnostic and Statistical Manual 5 (DSM-5) of mental health disorders. We...

  • Article
  • Open Access
1 Citations
2,780 Views
23 Pages

High-Precision, Automatic, and Fast Segmentation Method of Hepatic Vessels and Liver Tumors from CT Images Using a Fusion Decision-Based Stacking Deep Learning Model

  • Mamoun Qjidaa,
  • Anass Benfares,
  • Mohammed Amine El Azami El Hassani,
  • Amine Benkabbou,
  • Amine Souadka,
  • Anass Majbar,
  • Zakaria El Moatassim,
  • Maroua Oumlaz,
  • Oumayma Lahnaoui and
  • Abdeljabbar Cherkaoui
  • + 2 authors

Background: To propose an automatic liver and hepatic vessel segmentation solution based on a stacking model and decision fusion. This model combines the decisions of multiple models to achieve increased accuracy. It exhibits improved robustness due...

  • Article
  • Open Access
2,373 Views
13 Pages

Background: Pediatric Intensive Care Unit (PICU) outcome prediction is challenging, and machine learning (ML) can enhance it by leveraging large datasets. Methods: We built an ML model to predict PICU outcomes (“Death vs. Survival”, &ldqu...

  • Article
  • Open Access
1,407 Views
25 Pages

Quantum-Enhanced Dual-Backbone Architecture for Accurate Gastrointestinal Disease Detection Using Endoscopic Imaging

  • Nabil Marzoug,
  • Khidhr Halab,
  • Othmane El Meslouhi,
  • Zouhair Elamrani Abou Elassad and
  • Moulay A. Akhloufi

Background: Quantum machine learning (QML) holds significant promise for advancing medical image classification. However, its practical application to large-scale, high-resolution datasets is constrained by the limited number of qubits and the inhere...

  • Article
  • Open Access
3,702 Views
18 Pages

Background: Virtual coaching can help people adopt new healthful behaviors by encouraging them to set specific goals and helping them review their progress. One challenge in creating such systems is analyzing clients’ statements about their act...

  • Article
  • Open Access
2,114 Views
17 Pages

Co-Designing a DSM-5-Based AI-Powered Smart Assistant for Monitoring Dementia and Ongoing Neurocognitive Decline: Development Study

  • Fareed Ud Din,
  • Nabaraj Giri,
  • Namrata Shetty,
  • Tom Hilton,
  • Niusha Shafiabady and
  • Phillip J. Tully

Background/Objectives: Dementia is a leading cause of cognitive decline, with significant challenges for early detection and timely intervention. The lack of effective, user-centred technologies further limits clinical response, particularly in under...

  • Review
  • Open Access
3,588 Views
17 Pages

Real-Time Applications of Biophysiological Markers in Virtual-Reality Exposure Therapy: A Systematic Review

  • Marie-Jeanne Fradette,
  • Julie Azrak,
  • Florence Cousineau,
  • Marie Désilets and
  • Alexandre Dumais

Virtual-reality exposure therapy (VRET) is an emerging treatment for psychiatric disorders that enables immersive and controlled exposure to anxiety-provoking stimuli. Recent developments integrate real-time physiological monitoring, including heart...

  • Article
  • Open Access
1,902 Views
21 Pages

Stabilizing the Shield: C-Terminal Tail Mutation of HMPV F Protein for Enhanced Vaccine Design

  • Reetesh Kumar,
  • Subhomoi Borkotoky,
  • Rohan Gupta,
  • Jyoti Gupta,
  • Somnath Maji,
  • Savitri Tiwari,
  • Rajeev K. Tyagi and
  • Baldo Oliva

Background: Human Metapneumovirus (HMPV) is a respiratory virus in the Pneumoviridae family. HMPV is an enveloped, negative-sense RNA virus encoding three surface proteins: SH, G, and F. The highly immunogenic fusion (F) protein is essential for vira...

  • Review
  • Open Access
8 Citations
10,625 Views
70 Pages

Advancements in Breast Cancer Detection: A Review of Global Trends, Risk Factors, Imaging Modalities, Machine Learning, and Deep Learning Approaches

  • Md. Atiqur Rahman,
  • M. Saddam Hossain Khan,
  • Yutaka Watanobe,
  • Jarin Tasnim Prioty,
  • Tasfia Tahsin Annita,
  • Samura Rahman,
  • Md. Shakil Hossain,
  • Saddit Ahmed Aitijjo,
  • Rafsun Islam Taskin and
  • Touhid Bhuiyan
  • + 2 authors

Breast cancer remains a critical global health challenge, with over 2.1 million new cases annually. This review systematically evaluates recent advancements (2022–2024) in machine and deep learning approaches for breast cancer detection and ris...

  • Article
  • Open Access
906 Views
16 Pages

Background: The amount of data produced from biological experiments has increased geometrically, posing a challenge for the development of new methodologies that could enable their interpretation. We propose a novel approach for the analysis of trans...

  • Article
  • Open Access
1,410 Views
24 Pages

Accurate segmentation of kidney microstructures in whole slide images (WSIs) is essential for the diagnosis and monitoring of renal diseases. In this study, an end-to-end instance segmentation pipeline was developed for the detection of glomeruli and...

  • Article
  • Open Access
1 Citations
2,012 Views
15 Pages

SCCM: An Interpretable Enhanced Transfer Learning Model for Improved Skin Cancer Classification

  • Md. Rifat Aknda,
  • Fahmid Al Farid,
  • Jia Uddin,
  • Sarina Mansor and
  • Muhammad Golam Kibria

Skin cancer is the most common cancer worldwide, for which early detection is crucial to improve survival rates. Visual inspection and biopsies have limitations, including being error-prone, costly, and time-consuming. Although several deep learning...

  • Article
  • Open Access
1,614 Views
14 Pages

Deep Learning Treatment Recommendations for Patients Diagnosed with Non-Metastatic Castration-Resistant Prostate Cancer Receiving Androgen Deprivation Treatment

  • Chunyang Li,
  • Julia Bohman,
  • Vikas Patil,
  • Richard Mcshinsky,
  • Christina Yong,
  • Zach Burningham,
  • Matthew Samore and
  • Ahmad S. Halwani

Background: Prostate cancer (PC) is the second leading cause of cancer-related death in men in the United States. A subset of patients develops non-metastatic, castration-resistant PC (nmCRPC), for which management requires a personalized considerati...

  • Article
  • Open Access
1 Citations
2,544 Views
16 Pages

This paper proposes a hybrid method for skin lesion classification combining deep learning features with conventional descriptors such as HOG, Gabor, SIFT, and LBP. Feature extraction was performed by extracting features of interest within the tumor...

  • Article
  • Open Access
1,684 Views
19 Pages

Background: Social media represents a unique opportunity to investigate the perspectives of people with eating disorders at scale. One forum alone, r/EatingDisorders, now has 113,000 members worldwide. In less than a day, where a manual analysis migh...

  • Article
  • Open Access
2 Citations
2,880 Views
38 Pages

AI-Driven Bayesian Deep Learning for Lung Cancer Prediction: Precision Decision Support in Big Data Health Informatics

  • Natalia Amasiadi,
  • Maria Aslani-Gkotzamanidou,
  • Leonidas Theodorakopoulos,
  • Alexandra Theodoropoulou,
  • George A. Krimpas,
  • Christos Merkouris and
  • Aristeidis Karras

Lung-cancer incidence is projected to rise by 50% by 2035, underscoring the need for accurate yet accessible risk-stratification tools. We trained a Bayesian neural network on 300 annotated chest-CT scans from the public LIDC–IDRI cohort, integ...

  • Article
  • Open Access
1 Citations
2,193 Views
21 Pages

Technological advancements and AI-based research have significantly influenced our daily lives. Human activity recognition (HAR) is a key area at the intersection of various AI technologies and application domains. In this study, we present our novel...

  • Review
  • Open Access
13 Citations
23,447 Views
40 Pages

Generative Artificial Intelligence in Healthcare: Applications, Implementation Challenges, and Future Directions

  • Syed Arman Rabbani,
  • Mohamed El-Tanani,
  • Shrestha Sharma,
  • Syed Salman Rabbani,
  • Yahia El-Tanani,
  • Rakesh Kumar and
  • Manita Saini

Generative artificial intelligence (AI) is rapidly transforming healthcare systems since the advent of OpenAI in 2022. It encompasses a class of machine learning techniques designed to create new content and is classified into large language models (...

  • Article
  • Open Access
1 Citations
2,131 Views
29 Pages

Food pattern recognition plays a crucial role in modern healthcare by enabling automated dietary monitoring and personalised nutritional interventions, particularly for vulnerable populations with complex dietary needs. Current food recognition syste...

  • Article
  • Open Access
1 Citations
4,416 Views
23 Pages

Exploring CBC Data for Anemia Diagnosis: A Machine Learning and Ontology Perspective

  • Amira S. Awaad,
  • Yomna M. Elbarawy,
  • H. Mancy and
  • Naglaa E. Ghannam

Background: Anemia, a common health disorder affecting populations globally, demands timely and accurate diagnosis for treatment to be effective. The aim of this paper is to detect and classify four types of anemia: hgb, iron-deficiency, folate-defic...

  • Article
  • Open Access
5 Citations
3,666 Views
26 Pages

Background: Gliomas represent the most prevalent and aggressive primary brain tumors, requiring precise classification to guide treatment strategies and improve patient outcomes. Purpose: This study aimed to develop and evaluate a machine learning-dr...

  • Article
  • Open Access
1 Citations
3,590 Views
35 Pages

Background: Chronic diseases significantly burden healthcare systems due to the need for long-term treatment. Early diagnosis is critical for effective management and minimizing risk. The current traditional diagnostic approaches face various challen...

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BioMedInformatics - ISSN 2673-7426