Infections and Diarrhea of Enteric Coronaviruses in Pigs

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Pigs".

Deadline for manuscript submissions: 15 January 2025 | Viewed by 1719

Special Issue Editors


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Guest Editor
Institutes of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China
Interests: pathogenesis; antiviral strategies; vaccines; swine disease viruses

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Co-Guest Editor
State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China
Interests: porcine enteric coronavirus; metabolism; innate immune; autophagy

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Co-Guest Editor
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China
Interests: PEDV; virus; pigs

Special Issue Information

Dear Colleagues,

We are excited to present a new Special Issue of Animals on “Infections and Diarrhea of Enteric Coronaviruses in Pigs”. Porcine enteric coronaviruses (PECs), which include porcine epidemic diarrhea virus (PEDV), porcine delta coronavirus (PDCoV), transmissible gastroenteritis virus (TGEV), and swine acute diarrhea syndrome coronavirus (SADS-CoV), infect pigs of different ages and cause diarrhea, vomiting, and dehydration in piglets, with high morbidity and mortality. PECs, which have the potential to spread across species, are causing huge economic losses in the pig industry in China and the world. Therefore, studies focusing on PECs are urgent.

The aim of this Special Issue is to showcase the newest contributions in the field of porcine enteric coronavirus research, providing new insights into, and research on, unresolved issues. Papers exploring virus–host interactions, viral replication, pathogenesis, immunity, evolution, and novel antiviral strategies will be published in this Special Issue. Original research and review papers relevant to this area are particularly welcome.

Dr. Changchao Huan
Guest Editor

Dr. Yanrong Zhou
Dr. Longjun Guo
Co-Guest Editors

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Keywords

  • PEDV
  • PDCoV
  • TGEV
  • SADS-CoV
  • virus–host interaction
  • pathogenesis
  • immunity
  • antiviral strategies
  • evolution
  • viral replication

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Published Papers (2 papers)

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Research

13 pages, 3192 KiB  
Article
Phylogenetic and Genetic Variation Analysis of Porcine Epidemic Diarrhea Virus in East Central China during 2020–2023
by Liumei Sun, Duo Li, Caijie Yan, Chengyue Wu, Feng Han, Zongyi Bo, Manman Shen, Yiwei Sun, Liyan Wang, Haoqin Zheng, Mengdong Wang and Zhendong Zhang
Animals 2024, 14(15), 2185; https://doi.org/10.3390/ani14152185 - 26 Jul 2024
Viewed by 610
Abstract
Porcine epidemic diarrhea virus (PEDV) is a major causative pathogen of a highly contagious, acute enteric viral disease. This study evaluated the emergence of nine variants in Jiangsu and Anhui provinces of China from 2020 to 2023. S gene-based phylogenetic analysis indicated that [...] Read more.
Porcine epidemic diarrhea virus (PEDV) is a major causative pathogen of a highly contagious, acute enteric viral disease. This study evaluated the emergence of nine variants in Jiangsu and Anhui provinces of China from 2020 to 2023. S gene-based phylogenetic analysis indicated that three variants belong to the G1c subgroup, while the other six strains are clustered within the G2c subgroup. Recombination analyses supported that three variants of the G1c subgroup were likely derived from recombination of parental variants FR0012014 and a donor variant AJ1102. In addition, there are novel mutations on amino acid 141–148 and these likely resulted in changes in antigenicity in the three variants. These results illustrated that the study provides novel insights into the epidemiology, evolution, and transmission of PEDV in China. Full article
(This article belongs to the Special Issue Infections and Diarrhea of Enteric Coronaviruses in Pigs)
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16 pages, 15135 KiB  
Article
Investigation of Transmission and Evolution of PEDV Variants and Co-Infections in Northeast China from 2011 to 2022
by Feipeng Zhao, Xin’ao Ma, Jianfeng Yang, Zhiying Wei, Jiaxuan Li, Yanping Jiang, Wen Cui, Zhifu Shan and Lijie Tang
Animals 2024, 14(15), 2168; https://doi.org/10.3390/ani14152168 - 25 Jul 2024
Viewed by 761
Abstract
Porcine epidemic diarrhea virus (PEDV) is a rapidly evolving virus that causes outbreaks in pig herds worldwide. Mutations in the S protein of PEDV have led to the emergence of new viral variants, which can reduce vaccine immunity against prevalent strains. To understand [...] Read more.
Porcine epidemic diarrhea virus (PEDV) is a rapidly evolving virus that causes outbreaks in pig herds worldwide. Mutations in the S protein of PEDV have led to the emergence of new viral variants, which can reduce vaccine immunity against prevalent strains. To understand the infection and variation pattern of PEDV in China, an extensive epidemiological survey was conducted in northeast China from 2015 to 2022. The genetic diversity of enteroviruses co-infected with PEDV and the PEDV S gene was analyzed, common mutation patterns that may have led to changes in PEDV virulence and infectivity in recent years were identified, and structural changes in the surface of the S protein resulting from mutations in the PEDV S gene from 2011 to 2022 were reviewed. Of note, two distinct mutations in the emerging 2022 HEB strain were identified. These findings provide a basis for a better understanding of PEDV co-infection and genetic evolution in northeast China. Full article
(This article belongs to the Special Issue Infections and Diarrhea of Enteric Coronaviruses in Pigs)
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