Swine Intestinal Physiology and Microbiota Affected by Nutrition Management

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Nutrition".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 4552

Special Issue Editors

Guangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China
Interests: oxidative stress; sow; reproduction; milk synthesis; fatty acids

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Guest Editor
Guangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China
Interests: pig; sow; nutrients; mammary gland; lactation
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Special Issue Information

Dear Colleagues,

Over the past few decades, it has been increasingly recognized that microbial communities colonizing different regions of the gut act as a “double-edged sword” in terms of host health. In a healthy state, they can ferment dietary components to produce various metabolites, such as SCFAs, ferulic acid, and histamine, to provide nutrients and energy to the host and maintain the host’s intestinal metabolism and immune balance. However, negative consequences may include inflammation and infection, inducing gastrointestinal disorders, and possibly metabolic diseases (diabetes and obesity). Furthermore, nutrition significantly impacts microbial community composition in the short - and long-term, which opens new possibilities for health manipulation through nutrition management.

We invite you to publish areas of research that include but are not limited to bacteriology; biochemistry; epidemiology; immunology; microbiology; molecular biology; pathology.

This Special Issue aims to explore the impact of dietary nutrition on the gut microbiota and gut physiology (gut barrier and immune function). Second, we aim to shape the healthy microbiota composition and maintain host health through dietary habits.

  • Nutrition and the gut microbiota;
  • Intestinal microbiota and gut health;
  • Dysbiosis and the intestinal immune system;
  • Nutrition, gut barrier, and immune function.

Dr. Wutai Guan
Dr. Shihai Zhang
Guest Editors

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Keywords

  • nutrition
  • intestinal physiology
  • intestinal microbiota
  • host health
  • nutrition management

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Published Papers (3 papers)

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Research

18 pages, 4747 KiB  
Article
Fermented Chinese Herbs Improve the Growth and Immunity of Growing Pigs through Regulating Colon Microbiota and Metabolites
by Junhao Zhang, Zhiheng Shu, Sixiao Lv, Qingwen Zhou, Yuanhao Huang, Yingjie Peng, Jun Zheng, Yi Zhou, Chao Hu and Shile Lan
Animals 2023, 13(24), 3867; https://doi.org/10.3390/ani13243867 - 15 Dec 2023
Viewed by 1215
Abstract
(1) Background: the development of new antibiotic substitutes to promote pig growth and health has become an important way to solve the current dilemma and promote the pig industry. (2) Methods: to assess the effects of a fermented Chinese herbal (FCH) formula on [...] Read more.
(1) Background: the development of new antibiotic substitutes to promote pig growth and health has become an important way to solve the current dilemma and promote the pig industry. (2) Methods: to assess the effects of a fermented Chinese herbal (FCH) formula on the growth and immunity of growing pigs, 100 Duroc × Landrace × Yorshire three-way crossed growing pigs were randomly divided into control and treatment groups that were fed a basal diet, and a basal diet with 1% (group A), 2% (group B), and 3% (group C) FCH formulas, respectively. A sixty-day formal experiment was conducted, and their growth and serum indices, colonic microbiota, and metabolites were analyzed. (3) Results: the daily gain of growing pigs in groups A, B, and C increased by 7.93%, 17.68%, and 19.61%, respectively, and the feed-to-gain ratios decreased by 8.33%, 15.00%, and 14.58%, respectively. Serum immunity and antioxidant activities were significantly increased in all treatment groups. Particularly, adding a 2% FCH formula significantly changed the colon’s microbial structure; the Proteobacteria significantly increased and Firmicutes significantly decreased, and the metabolite composition in the colon’s contents significantly changed. (4) Conclusions: these results indicate that the FCH formula is a good feed additive for growing pigs, and the recommended addition ratio was 3%. Full article
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17 pages, 3474 KiB  
Article
Dietary Supplementation with Lysozyme–Cinnamaldehyde Conjugates Enhances Feed Conversion Efficiency by Improving Intestinal Health and Modulating the Gut Microbiota in Weaned Piglets Infected with Enterotoxigenic Escherichia coli
by Zhezhe Tian, Jiaming Chen, Tongbin Lin, Junhua Zhu, Haoyang Gan, Fang Chen, Shihai Zhang and Wutai Guan
Animals 2023, 13(22), 3497; https://doi.org/10.3390/ani13223497 - 13 Nov 2023
Cited by 1 | Viewed by 1408
Abstract
This study aims to evaluate the efficacy of lysozyme–cinnamaldehyde conjugates (LC) as a potential alternative to antibiotics in treating piglets infected with enterotoxigenic Escherichia coli (ETEC). The results demonstrated that piglets fed with the LC diet exhibited lower rectal temperature and fecal scores [...] Read more.
This study aims to evaluate the efficacy of lysozyme–cinnamaldehyde conjugates (LC) as a potential alternative to antibiotics in treating piglets infected with enterotoxigenic Escherichia coli (ETEC). The results demonstrated that piglets fed with the LC diet exhibited lower rectal temperature and fecal scores at 9 h, 24 h, and 48 h post-ETEC challenge. Furthermore, LC supplementation led to significant improvements in the mechanical and immune barriers of the jejunum and ileum, as indicated by an increased villi-height-to-crypt-depth ratio (VCR) and the expression of tight junction proteins, mucin, and β-defensins. Furthermore, the LC diet lowered the levels of pro-inflammatory cytokines TNF-α and IL-1β in the plasma. Further analyses showed that the LC diet downregulated genes (specifically TLR4 and MyD88) linked to the TLRs/MyD88/NF-κB signaling pathway in the small intestine. Additionally, 16SrDNA sequencing data revealed that LC supplementation increased the α diversity of intestinal microorganisms and the relative abundance of Lactobacillus. In summary, the LC-supplemented diet effectively mitigated the adverse effects of E. coli K88, including intestinal barrier damage and inflammation. Furthermore, it improved the structure of the intestinal flora, ultimately contributing to better growth performance in piglets. Full article
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15 pages, 720 KiB  
Article
Effect of Particle Size of Wheat and Barley Grain on the Digestibility and Fermentation of Carbohydrates in the Small and Large Intestines of Growing Pigs
by Geon-Il Lee, Knud Erik Bach Knudsen and Mette Skou Hedemann
Animals 2023, 13(12), 1986; https://doi.org/10.3390/ani13121986 - 14 Jun 2023
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Abstract
The objective of this investigation was to study the effects of different cereal types, barley and wheat, with different particle sizes (PS) on the recovery of ileal digesta and fecal excretion, digestion of nutrients and fiber components, mean transit time (MTT), and short-chain [...] Read more.
The objective of this investigation was to study the effects of different cereal types, barley and wheat, with different particle sizes (PS) on the recovery of ileal digesta and fecal excretion, digestion of nutrients and fiber components, mean transit time (MTT), and short-chain fatty acid content and composition in growing pigs studied in two experiments. Five barrows with ileal cannulas (initial BW 35.9 ± 1.5 kg) in Experiment 1 and thirty-two castrated pigs (30.8 ± 1.3 kg) in Experiment 2 were fed four different diets: barley fine, barley coarse, wheat fine and wheat coarse diets. The cereal type and PS did not influence the relative weight of the small and large intestines and pH of digesta, whereas MTT in the large intestine of pigs fed the coarse barley diet was lower compared to pigs fed other diets (p < 0.05). Pigs fed the coarse barley diet had lower apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of nutrients and fiber (p < 0.05), whereas pigs fed the fine barley diet had similar AID and ATTD to pigs fed wheat fine and coarse diets (p < 0.05). In conclusion, the barley diet was more influenced by PS in comparison to wheat, thereby inducing lower AID and ATTD of nutrient. Full article
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