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Antioxidants
Special Issues
Oxidative Stress in Livestock and Poultry—3rd Edition
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Oxidative Stress in Livestock and Poultry—3rd Edition

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 30 September 2025 | Viewed by 1813

Special Issue Editors

Prof. Dr. Wutai Guan

E-Mail Website
Guest Editor
Guangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China
Interests: oxidative stress; sow; reproduction; milk synthesis; fatty acids
Special Issues, Collections and Topics in MDPI journals
Dr. Shihai Zhang

E-Mail Website
Guest Editor
Guangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China
Interests: pig; sow; nutrients; mammary gland; lactation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Building on the success of our previous Special Issues on "Oxidative Stress and its Impact on Livestock and Poultry Production", we are excited to announce the launch of our third issue for the year 2024–2025. As the field of oxidative stress research continues to evolve, we find ourselves at the forefront of groundbreaking discoveries that have profound implications for livestock and poultry production.

Recent advancements have highlighted the intricate interplay between oxidative stress and various physiological processes in livestock and poultry. Beyond the well-documented impacts on feed intake, feed conversion ratio, disease resistance, and mortality, emerging research has uncovered the role of oxidative stress in modulating the gut microbiome, influencing metabolic pathways, and even affecting the epigenetic landscape of livestock species. These findings suggest that oxidative stress not only poses direct challenges to livestock health and productivity, but also has long-term implications for the sustainability of animal husbandry practices.

This Special Issue will delve into the latest research exploring these multifaceted relationships. We are particularly interested in contributions that address: (1) oxidative stress and gut microbiome dynamics; (2) oxidative stress: metabolic and epigenetic alterations; (3) innovative strategies to mitigate oxidative stress; and (4) environmental and management-induced oxidative stress.

We invite researchers from diverse disciplines to contribute original research articles and reviews that will advance our understanding of oxidative stress in livestock and poultry production. Your contributions will play a critical role in shaping future research directions and informing practical solutions to enhance animal welfare and productivity.

We look forward to receiving your valuable submissions and continuing our collaboration in this rapidly advancing field.

Prof. Dr. Wutai Guan
Dr. Shihai Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • environmental stressors
  • gut microbiome
  • antioxidant strategies
  • epigenetic modifications

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

19 pages, 1657 KiB  
Article
Effects of Dietary Protein Levels on Meat Quality, Serum Antioxidant Capacity, and Intestinal Microorganisms in Ningxiang Pigs
by Shanghang Liu, Kai Yang, Jie Yin, Jiashun Chen, Qian Jiang, Jing Wang, Bie Tan, Xiaokang Ma and Juan Liu
Antioxidants 2025, 14(4), 415; https://doi.org/10.3390/antiox14040415 - 30 Mar 2025
Viewed by 328
Abstract
This study aimed to evaluate the impact of five different dietary protein levels on meat quality, serum antioxidant capacity, and intestinal microorganisms of Ningxiang pigs, thus providing new insights into their nutritional needs. One hundred and twenty-five healthy Ningxiang barrows with an average [...] Read more.
This study aimed to evaluate the impact of five different dietary protein levels on meat quality, serum antioxidant capacity, and intestinal microorganisms of Ningxiang pigs, thus providing new insights into their nutritional needs. One hundred and twenty-five healthy Ningxiang barrows with an average body weight of 53.19 ± 2.12 kg were randomly divided into five groups with five replicates and five pigs per replicate. The diet was formulated using corn, soybean meal, and rice bran meal as raw materials based on net energy. Following the nutritional requirements outlined in the Nutrient Requirements of Swine in China (2020), diets with five different protein levels (crude protein: 11.09%, 12.09%, 13.09%, 14.09%, 15.09%) were formulated. The amino acid levels of lysine, threonine, tryptophan, methionine, valine, isoleucine, and other amino acids were standardized to meet the recommended values, as were other essential amino acids. The experiment lasted for 62 days. The results indicated a linear decrease in the redness and yellowness values of the Longissimus dorsi muscle with increased dietary protein, alongside a quadratic decrease in intramuscular fat (p < 0.01). Notably, muscles from pigs fed with 13.09%, 14.09%, and 15.09% protein diets exhibited significantly lower redness and yellowness than those on a 12.09% protein diet (p < 0.05). Additionally, higher dietary protein levels linearly enhanced the presence of specific fatty acids (C17:0, C17:1, C18:3n3, and C18:3n6) and certain amino acids in the Longissimus dorsi muscle, following a quadratic trend (p < 0.01). The serum GSH-Px content increased linearly with greater dietary protein levels (p < 0.05). Significant variations in cecal and colonic metabolites were observed across different protein levels, affecting the contents of putrescine, cadaverine, spermine, spermidine, and short-chain fatty acids (p < 0.05). Additionally, the increase in dietary protein levels correlates with the growth performance and amino acid profile of the Longissimus dorsi muscle in Ningxiang pigs, presenting a quadratic relationship. Concurrently, the serum antioxidant capacity and cecal bioamine content demonstrate a linear increase. Despite a balanced inclusion of six essential amino acids, both excessively high and low protein levels adversely affect growth and intestinal health. Notably, dietary protein levels of 12.09% and 13.09% yield the optimal growth performance under the specified experimental conditions. Full article
(This article belongs to the Special Issue Oxidative Stress in Livestock and Poultry—3rd Edition)
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23 pages, 2111 KiB  
Article
Transfer of Antioxidant Capacity Through Placenta and Colostrum: β-Carotene and Superoxide Dismutase Collaboratively Enhance Integrated Breeding of Sows and Piglets
by Jun Huang, Shengkai Li, Jung Yeol Sung, Shiyan Qiao, Xiangfang Zeng and Junyan Zhou
Antioxidants 2025, 14(3), 359; https://doi.org/10.3390/antiox14030359 - 18 Mar 2025
Viewed by 425
Abstract
Sows and piglets face heightened oxidative stress during gestation and lactation, yet strategies to simultaneously mitigate these challenges remain underexplored. This study investigated the effects of β-carotene and superoxide dismutase (SOD) supplementation on 140 Landrace × Yorkshire sows (parity 3–5) randomly assigned to [...] Read more.
Sows and piglets face heightened oxidative stress during gestation and lactation, yet strategies to simultaneously mitigate these challenges remain underexplored. This study investigated the effects of β-carotene and superoxide dismutase (SOD) supplementation on 140 Landrace × Yorkshire sows (parity 3–5) randomly assigned to (1) a control; (2) long-term low-dose treatment (25 mg/kg β-carotene, 4 mg/kg SOD, or both) throughout gestation–lactation; or (3) short-term high-dose treatment (100 mg/kg β-carotene, 14 mg/kg SOD, or both) administered 7 days pre/post-weaning and farrowing. Our data indicate that the antioxidants enhanced the productive performance of both sows and piglets, with the most pronounced effect observed in the long-term, low-dose combined administration of β-carotene and SOD. The composite antioxidants significantly improved the systemic antioxidant capacity in sows, while concurrently reducing the cortisol and lipopolysaccharide concentrations in the serum. This enhancement contributed to elevations in serum progesterone and prolactin levels at day 40 of gestation and farrowing, respectively, ultimately increasing the number of weaned piglets and decreasing the backfat loss. In addition, the compound antioxidants improved the serum antioxidant indices of piglets, increased the growth hormone concentrations, and improved the litter weight gain. Mechanistically, the placental upregulation of CAT, GPX1, and GLUT3, alongside Claudin1, Occludin, and ZO-1 expression, underpinned improved nutrient transport and barrier function. These findings demonstrate that β-carotene and SOD synergistically transfer antioxidant capacity via placental and colostrum pathways, offering a viable strategy for integrated sow–piglet management. Full article
(This article belongs to the Special Issue Oxidative Stress in Livestock and Poultry—3rd Edition)
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Graphical abstract

16 pages, 6360 KiB  
Article
Selenium Yeast Attenuated Lipopolysaccharide-Induced Inflammation in Porcine Mammary Epithelial Cells by Modulating MAPK and NF-κB Signaling Pathways
by Zhenting He, Senlin Su, Bing Zhang, Dongpang Chen, Siyu Yuan, Wutai Guan and Shihai Zhang
Antioxidants 2025, 14(3), 334; https://doi.org/10.3390/antiox14030334 - 12 Mar 2025
Viewed by 562
Abstract
Mastitis, a prevalent inflammatory disease in mammals, disrupts mammary gland function, compromises milk quality, and can contribute to increased offspring morbidity and mortality. Maintaining the health of porcine mammary epithelial cells (PMECs), the primary cell type in the mammary gland, is crucial for [...] Read more.
Mastitis, a prevalent inflammatory disease in mammals, disrupts mammary gland function, compromises milk quality, and can contribute to increased offspring morbidity and mortality. Maintaining the health of porcine mammary epithelial cells (PMECs), the primary cell type in the mammary gland, is crucial for minimizing the adverse effects of this disease. Selenium yeast (SeY), an organic selenium compound known for its antioxidant and immune-enhancing properties, has yet to be fully understood in its role in modulating inflammation in mammary gland. In this study, lipopolysaccharide (LPS) (50 µg/mL, 24 h) significantly upregulated the expression of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-1β (IL-1β) (p < 0.05). Pretreatment with 1 µM SeY significantly attenuated the LPS-induced inflammatory response by reducing the levels of TNF-α, IL-6, IL-8, and IL-1β (p < 0.05). Additionally, SeY enhanced cellular antioxidant defenses by increasing total antioxidant capacity (T-AOC), superoxide dismutase (SOD) activity, glutathione (GSH) levels, and glutathione peroxidase (GSH-Px) activity, while concurrently decreasing malondialdehyde (MDA) accumulation (p < 0.05). SeY also restored both intracellular and extracellular triglyceride levels and rescued lipid droplet formation, which were disrupted by LPS treatment. Furthermore, SeY upregulated key regulators involved in milk synthesis (p < 0.05). These findings suggest that SeY effectively mitigates LPS-induced inflammation and oxidative stress while preserving critical pathways for milk fat and protein synthesis in PMECs. Full article
(This article belongs to the Special Issue Oxidative Stress in Livestock and Poultry—3rd Edition)
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