Splenic Pathologies in Companion Animals

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Companion Animals".

Deadline for manuscript submissions: closed (20 February 2022) | Viewed by 6084

Special Issue Editors

Department of Comparative Biomedicine and Food Science, Università degli Studi di Padova, Padua, Italy
Interests: veterinary dermatopathology; splenic pathologies of dogs and cats; oral pathologies of dogs and cats

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Co-Guest Editor
Department of Comparative Biomedicine and Food Science, University of Padova, 35020 Legnaro, Italy
Interests: marine mammal pathology and diseases; new techniques; cell culture techniques
Special Issues, Collections and Topics in MDPI journals

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Co-Guest Editor
1. Department of Comparative Biomedicine and Food Science, Università degli Studi di Padova, Padua, Italy
2. Department of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Interests: oncology; canine and feline mammary tumors; human breast cancer; metastasis; extracellular vesicles

Special Issue Information

Dear Colleagues,

The spleen is a complex multifunctional organ that can represent a clinical and surgical challenge in veterinary practice. Pathologies of the spleen are often discovered in the late phase of the disease and, when a secondary rupture of the organ occurs, they can represent a surgical emergency and a life-threatening condition. Many can be due to the lesions involved in splenic pathologies. The splenic macrophagic compartment can harbor several etiological agents involved in infectious diseases. Inflammations of the spleen are still poorly understood and probably underestimated. Because of the extended vascular component, circulatory disturbances can be responsible for organ hemorrhages. Finally, many neoplasms can arise from the splenic parenchyma, especially from the endothelial component and from the hematopoietic compartment. Early diagnosis and appropriate treatments of all these pathological entities, then, are of scientific importance in veterinary medicine. Furthermore, since the spleen is an internal organ that is difficult to reach, new alternative noninvasive methods of diagnosis are needed.

For this Special Issue, we welcome original research articles on any aspect regarding the spleen in companion animals, from infectious diseases, congenital anomalies, inflammatory diseases, and neoplastic processes to diagnosis and clinical and surgical treatments of the various entities, with a particular interest in novel techniques. Review articles are also welcome. Studies on novel splenic cell lines and on splenic cell-derived extracellular vesicles will be of particular interest.

Dr. Silvia Ferro
Dr. Cinzia Centelleghe
Dr. Alessandro Sammarco
Guest Editors

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Keywords

  • spleen
  • splenic neoplasms
  • splenic hematopoietic disorders
  • splenic hemangiosarcoma
  • splenic histiocytic sarcoma
  • splenic lymphoma
  • splenitis
  • physiopathology of splenic disorders
  • canine splenic cell line
  • extracellular vesicles
  • splenic cytology
  • companion animals

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Published Papers (1 paper)

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Research

13 pages, 706 KiB  
Article
Epidemiology and Survival of Dogs Diagnosed with Splenic Lymphoid Hyperplasia, Complex Hyperplasia, Stromal Sarcoma and Histiocytic Sarcoma
by Cleide H. Spröhnle-Barrera, Jayne McGhie, Rachel E. Allavena, Helen C. Owen, Chiara Palmieri and Tamsin S. Barnes
Animals 2022, 12(8), 960; https://doi.org/10.3390/ani12080960 - 8 Apr 2022
Cited by 2 | Viewed by 5140
Abstract
Canine splenic fibrohistiocytic nodules traditionally encompassed benign lymphoid hyperplasia, complex hyperplasia, and malignant fibrous histiocytoma. The latter has been recently re-classified into histiocytic sarcoma and stromal sarcoma. Reliable indicators of post-splenectomy survival and demographic factors predisposing to the four types of nodules are [...] Read more.
Canine splenic fibrohistiocytic nodules traditionally encompassed benign lymphoid hyperplasia, complex hyperplasia, and malignant fibrous histiocytoma. The latter has been recently re-classified into histiocytic sarcoma and stromal sarcoma. Reliable indicators of post-splenectomy survival and demographic factors predisposing to the four types of nodules are not completely understood. This study aims to estimate frequency, survival times, and identify risk factors of splenectomized dogs diagnosed with lymphoid hyperplasia, complex hyperplasia, histiocytic sarcoma, and stromal sarcoma using medical records containing histopathological diagnosis from the VetCompass Australia database (1989–2018), which collects demographic, and clinical information from veterinary clinics. Out of 693 dogs, 315 were diagnosed with fibrohistiocytic nodules, mostly lymphoid hyperplasia (169/693, 24.4%), followed by stromal sarcoma (59/693, 8.5%), complex hyperplasia (55/693, 7.9%), and histiocytic sarcoma (32/693, 4.6%). Dogs aged 8–10 years were more likely to be diagnosed with histiocytic or stromal sarcoma than lymphoid hyperplasia. Dogs diagnosed with lymphoid hyperplasia had a longer survival time than those with other diagnoses (median > 2 years). Dogs diagnosed with histiocytic sarcoma had longer survival times (median 349 days) than stromal sarcoma (median 166 days). Results suggest that knowledge of the type of splenic fibrohistiocytic nodule, patients’ age, and sex can be used to increase prognostic accuracy. Full article
(This article belongs to the Special Issue Splenic Pathologies in Companion Animals)
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