Antimicrobial Agents in Prevention and Treatment of Oral Diseases

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: 30 November 2024 | Viewed by 993

Special Issue Editor


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Guest Editor
Department of Periodontology School of Dental Medicine University of Bern, Bern, Switzerland
Interests: antimicrobial therapy in dentistry; biofilms; antibiotics; alternatives to antibiotics
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Special Issue Information

Dear Colleagues,

The Special Issue “Antimicrobial agents in Prevention and Treatment of Oral Diseases” focuses on the use of antimicrobial agents in oral healthcare. Antimicrobial agents, including antiseptics, antibiotics and antifungals are commonly used to prevent and treat oral diseases, such as caries, periodontitis, and oral infections. The effectiveness of these agents in oral healthcare is a topic of ongoing research and debate, as their use can lead to the development of antimicrobial resistance and other adverse effects.

The Special Issue also covers a wide range of topics related to antimicrobial agents in oral healthcare, such as the efficacy of specific antimicrobial agents in preventing and treating oral diseases, and the safety and potential side effects of these agents. Additionally, we welcome submissions focusing on the development of new antimicrobial agents for use in oral healthcare.

Prof. Dr. Sigrun Eick
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • periodontitis
  • candidiasis
  • antibiotics
  • antiseptics
  • adverse effects
  • development of resistance

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Published Papers (1 paper)

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Research

23 pages, 6154 KiB  
Article
Preclinical Validation of MIN-T: A Novel Controlled-Released Formulation for the Adjunctive Local Application of Minocycline in Periodontitis
by Małgorzata Benedyk-Machaczka, Piotr Mydel, Karsten Mäder, Marta Kaminska, Nadine Taudte, Marcel Naumann, Martin Kleinschmidt, Sandra Sarembe, Andreas Kiesow, Sigrun Eick and Mirko Buchholz
Antibiotics 2024, 13(11), 1012; https://doi.org/10.3390/antibiotics13111012 - 28 Oct 2024
Viewed by 661
Abstract
Background: Adjunctive treatment of periodontitis lacks solutions which allow for enough time for wound healing in the periodontal pockets by avoiding fast re-colonization. Such a solution might be an antibiotic-containing formulation with a controlled release over a period of weeks. Here, a recently [...] Read more.
Background: Adjunctive treatment of periodontitis lacks solutions which allow for enough time for wound healing in the periodontal pockets by avoiding fast re-colonization. Such a solution might be an antibiotic-containing formulation with a controlled release over a period of weeks. Here, a recently described minocycline-containing approach is qualified for further clinical development by focusing on proof-of-concept, systemic burden, resistance development, and degradation studies. Methods: Animal studies were done in two different (mouse-chamber, rat Porphyromonas gingivalis challenging) models, including effects on inflammation markers, bone loss, and bone structure. Also, serum concentrations of minocycline after local application were determined by HPLC-MS/MS. The resistance status of bacterial clinical isolates against minocycline was investigated and the degradation of the formulation was characterized by laser scanning and scanning electron microscopy. Results: Animal studies clearly demonstrated the applicability of the new formulation in the investigated models. Inflammation markers decreased in a dose-dependent manner and reduced bone loss compared to non-treated group was observed. Therefore, the systemic burden of the antibiotic was neglectable. Minocycline is still effective against oral pathogens; resistance development was not seen. The biodegradable thread was first swollen and subsequently degraded over a period of weeks. Conclusions: The results support the continued clinical development of this new formulation. A phase I clinical trial is planned to further evaluate its safety and efficacy. Full article
(This article belongs to the Special Issue Antimicrobial Agents in Prevention and Treatment of Oral Diseases)
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