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Antibiotics
Special Issues
Antimicrobial and Antibiofilm Activity by Natural Compounds
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Antimicrobial and Antibiofilm Activity by Natural Compounds

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Plant-Derived Antibiotics".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 1669

Special Issue Editors

Prof. Dr. Galdino Andrade

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Guest Editor
Microbial Ecology Laboratory, Department of Microbiology, State University of Londrina, Londrina, Brazil
Interests: bioactive compounds; antibiotic activity; biofilm
Special Issues, Collections and Topics in MDPI journals
Dr. Sueli F. Yamada-Ogatta

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Guest Editor
Laboratory of Molecular Biology of Microorganisms, Department of Microbiology, State University of Londrina, Londrina, Brazil
Interests: antimicrobial activity; antibiofilm activity; virulence; natural products
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Martha Viviana Torres Cely

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Guest Editor
Laboratory of Soil Microbiology and Agricultural Biotechnology, Agricultural and Environmental Sciences Institute, Federal University of Mato Grosso, Cuiaba, Brazil
Interests: soil microbiology; biodiversity; microbial ecolgy; arbuscular mycorrhizal fungi-Inoculant production

Special Issue Information

Dear Colleagues,

Natural compounds should be obtained from different sources, such as microbial and plants sources. Many compounds show antimicrobial and antibiofilm activity, and the discovery of new molecules is a challenge to control multiresitant microorganisms and biofilm formation. For this Special Issue, we invite all researchers to publish results and reviews about the state of the art of different aspects of natural compounds and the potential to use in the future by the pharmaceutical industry. On the other hand, phytopathogenic microorganisms, especially fungi, show resistance against a large amount of fungicide, which is a big problem for crop production. In conclusion, natural compounds are a wild source for the discovery of new molecules that will aid animal and human health as well as crop production.

Prof. Dr. Galdino Andrade
Dr. Sueli F. Yamada-Ogatta
Prof. Dr. Martha Viviana Torres Cely
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pathogens
  • human
  • animal
  • crops
  • antibiotic

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Published Papers (1 paper)

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Research

17 pages, 4616 KiB  
Article
Fluopsin C Promotes Biofilm Removal of XDR Acinetobacter baumannii and Presents an Additive Effect with Polymyxin B on Planktonic Cells
by Leandro Afonso, Kathlen Giovana Grzegorczyk, Julio Martins Salomão, Kawany Roque Basso, Leonardo Cruz Alves, Maria Clara Davis Silva, Andreas Lazaros Chryssafidis, Bárbara Gionco-Cano, Sueli Fumie Yamada-Ogatta and Galdino Andrade
Antibiotics 2024, 13(9), 875; https://doi.org/10.3390/antibiotics13090875 - 12 Sep 2024
Viewed by 1301
Abstract
Acinetobacter baumannii emerged as one of the most important pathogens for the development of new antimicrobials due to the worldwide detection of isolates resistant to all commercial antibiotics, especially in nosocomial infections. Biofilm formation enhances A. baumannii survival by impairing antimicrobial action, being [...] Read more.
Acinetobacter baumannii emerged as one of the most important pathogens for the development of new antimicrobials due to the worldwide detection of isolates resistant to all commercial antibiotics, especially in nosocomial infections. Biofilm formation enhances A. baumannii survival by impairing antimicrobial action, being an important target for new antimicrobials. Fluopsin C (FlpC) is an organocupric secondary metabolite with broad-spectrum antimicrobial activity. This study aimed to evaluate the antibiofilm activity of FlpC in established biofilms of extensively drug-resistant A. baumannii (XDRAb) and the effects of its combination with polymyxin B (PolB) on planktonic cells. XDRAb susceptibility profiles were determined by Vitek 2 Compact, disk diffusion, and broth microdilution. FlpC and PolB interaction was assessed using the microdilution checkerboard method and time–kill kinetics. Biofilms of XDRAb characterization and removal by FlpC exposure were assessed by biomass staining with crystal violet. Confocal Laser Scanning Microscopy was used to determine the temporal removal of the biofilms using DAPI, and cell viability using live/dead staining. The minimum inhibitory concentration (MIC) of FlpC on XDRAb was 3.5 µg mL−1. Combining FlpC + PolB culminated in an additive effect, increasing bacterial susceptibility to both antibiotics. FlpC-treated 24 h biofilms reached a major biomass removal of 92.40 ± 3.38% (isolate 230) using 7.0 µg mL−1 FlpC. Biomass removal occurred significantly over time through the dispersion of the extracellular matrix and decreasing cell number and viability. This is the first report of FlpC’s activity on XDRAb and the compound showed a promissory response on planktonic and sessile cells, making it a candidate for the development of a new antimicrobial product. Full article
(This article belongs to the Special Issue Antimicrobial and Antibiofilm Activity by Natural Compounds)
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