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Antibiotics
Special Issues
Silver and Gold Compounds as Antibiotics, 2nd Edition
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Silver and Gold Compounds as Antibiotics, 2nd Edition

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Mechanisms and Structural Biology of Antibiotic Action".

Deadline for manuscript submissions: 15 January 2025 | Viewed by 1826

Special Issue Editors

Prof. Dr. Sotiris K Hadjikakou

E-Mail Website
Guest Editor
Section of Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 451 10 Ioannina, Greece
Interests: crystal structure; structure determination; material characterization; structural chemistry; biological inorganic chemistry, antimicrobial compounds; antiproliferative compounds
Special Issues, Collections and Topics in MDPI journals
Dr. Christina N. Banti

E-Mail Website
Guest Editor
Section of Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 451 10 Ioannina, Greece
Interests: biological inorganic chemistry; anticancer metallodrugs; antibacterial metallodrugs
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The inaugural volume of the Special Issue, "Silver and Gold Compounds as Antibiotics," featured ten papers. Encouraged by the response from scientists in the field, we are now launching a second volume centered on the same theme.

Following the path established by the initial volume, this second edition will highlight recent research and review articles within biological inorganic chemistry. Specifically, it will explore the antimicrobial properties of silver and gold compounds, encompassing their nanoparticles.

This second volume aims to provide a comprehensive perspective on this evolving field, presenting recent breakthroughs and the most current research. The focus will remain on the role of silver or gold compounds and their nanoparticles as antibiotics. Readers engaging with this Special Issue will acquire an extensive understanding of antimicrobial metal compounds.

Prof. Dr. Sotiris K Hadjikakou
Dr. Christina N. Banti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bio-inorganic chemistry
  • metal compounds
  • antimicrobial drugs
  • antibiotics
  • medical applications
  • antimicrobial resistance

Published Papers (2 papers)

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Research

13 pages, 3364 KiB  
Article
Synergistic Antimicrobial Activity of Biogenic Silver Nanoparticles and Acanthospermum australe Essential Oil against Skin Infection Pathogens
by Javier Mussin and Gustavo Giusiano
Antibiotics 2024, 13(7), 674; https://doi.org/10.3390/antibiotics13070674 - 20 Jul 2024
Viewed by 525
Abstract
In response to the steady increase in antimicrobial-resistant strains, the World Health Organisation has emphasised the need to investigate new antimicrobial agents and alternative therapies that improve the spectrum of activity and reduce the dose required, thus improving safety. This study focused on [...] Read more.
In response to the steady increase in antimicrobial-resistant strains, the World Health Organisation has emphasised the need to investigate new antimicrobial agents and alternative therapies that improve the spectrum of activity and reduce the dose required, thus improving safety. This study focused on the characterisation of Acanthospermum australe essential oil and green-synthesis silver nanoparticles (AgNP), evaluating their cytotoxicity in human cells, antimicrobial activity and synergistic effect against pathogens causing skin infections. The main components of the essential oil were germacrene A (24.07%), γ-cadinene (21.47%) and trans-caryophyllene (14.97%). Spherical AgNP with a diameter of 15 ± 3 nm were synthesised. The essential oil showed antimicrobial activity against dermatophytes and Malassezia globosa, while AgNP were found to be active against bacteria, yeasts and dermatophytes. Both compounds were found to be primarily non-cytotoxic at the concentrations required to inhibit microbial growth. Furthermore, the combined use of essential oil and AgNP showed a synergistic antimicrobial effect against dermatophytes and M. globosa. In conclusion, the results suggest that the combined use of bioactive compounds from natural sources, such as essential oil and biogenic AgNP, has the potential to improve antimicrobial efficacy against specific skin pathogens, particularly Microsporum canis, Nannizzia gypsea and M. globosa. Full article
(This article belongs to the Special Issue Silver and Gold Compounds as Antibiotics, 2nd Edition)
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13 pages, 17585 KiB  
Article
Combinations of Cannabinoids with Silver Salts or Silver Nanoparticles for Synergistic Antibiotic Effects against Methicillin-Resistant Staphylococcus aureus
by John Jackson, Ali Shademani, Manisha Dosanjh, Claudia Dietrich, Mark Pryjma, Dana M. Lambert and Charles J. Thompson
Antibiotics 2024, 13(6), 473; https://doi.org/10.3390/antibiotics13060473 - 22 May 2024
Viewed by 987
Abstract
Silver has been shown to improve the antibiotic effects of other drugs against both Gram- positive and -negative bacteria. In this study, we investigated the antibiotic potential of cannabidiol (CBD), cannabichromene (CBC) and cannabigerol (CBG) and their acidic counterparts (CBDA, CBCA, CBGA) against [...] Read more.
Silver has been shown to improve the antibiotic effects of other drugs against both Gram- positive and -negative bacteria. In this study, we investigated the antibiotic potential of cannabidiol (CBD), cannabichromene (CBC) and cannabigerol (CBG) and their acidic counterparts (CBDA, CBCA, CBGA) against Gram-positive bacteria and further explored the additive or synergistic effects of silver nitrate or silver nanoparticles using 96-well plate growth assays and viability (CFUs- colony-forming units). All six cannabinoids had strong antibiotic effects against MRSA with minimal inhibitory concentrations (MICs) of 2 mg/L for CBG, CBD and CBCA; 4 mg/L for CBGA; and 8 mg/L for CBC and CBDA. Using 96-well checkerboard assays, CBC, CBG and CBGA showed full or partial synergy with silver nitrate; CBC, CBDA and CBGA were fully synergistic with silver nanoparticles against MRSA. Using CFU assays, combinations of CBC, CBGA and CBG with either silver nitrate or silver nanoparticles, all at half or quarter MICs, demonstrated strong, time-dependent inhibition of bacterial growth (silver nitrate) and bactericidal effects (silver nanoparticles). These data will lead to further investigation into possible biomedical applications of specific cannabinoids in combination with silver salts or nanoparticles against drug-resistant Gram-positive bacteria. Full article
(This article belongs to the Special Issue Silver and Gold Compounds as Antibiotics, 2nd Edition)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Unlocking Nature's Power: Silver Nanoparticles and Acanthospermum australe Essential Oil Join Forces Against Pathogens Causing Skin Infections

Javier Mussin; Gustavo Giusiano.

Affiliation: Instituto de Medicina Regional, Universidad Nacional del Nordeste, Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Av. Las Heras 727, 3500 Resistencia, Chaco, Argentina.

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