New Beta-Lactamase Inhibitors Research and Development: Sword for Antimicrobial Resistance
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Novel Antimicrobial Agents".
Deadline for manuscript submissions: closed (20 August 2024) | Viewed by 1596
Special Issue Editor
Interests: antimicrobial resistance; novel antimicrobial agents; β-lactamases; MDR Gram-negative infections; rapid diagnostics; precision antimicrobial chemotherapy
Special Issue Information
Dear Colleagues,
The evolution and spread of β-lactamases in Gram-negative bacteria present challenges in the treatment of many infections for which β-lactams (penicillins, cephalosporins, carbapenems) are employed. The combination of a β-lactam (BL) with a β-lactamase inhibitor (BLI) is a proven strategy to address this problem. In recent years, there have been efforts to design novel BLIs (diazobicyclooctanes, boronic acids) and to repurpose older drugs (clavulanate, tazobactam, sulbactam) in novel therapeutic combinations.
Although a number of new BL/BLI preparations are entering clinical application (ceftazidime/avibactam, ceftolozone/tazobactam, imipenem/relebactam, meropenem/vaborbactam), these are already compromised by the emergence of resistance. Most also lack useful activity against key MDR pathogens (Acinetobacter, Pseudomonas) and do not inhibit the metallo-β-lactamases (NDM, IMP, VIM) responsible for carbapenem resistance.
In this Special Issue, we seek manuscripts that review or provide insights into the development or repurposing of novel or existing BL/BLI combination therapies. This may include articles on chemical and biochemical activity, the mechanisms of genotypic and phenotypic resistance, regional epidemiological surveillance studies, in vitro susceptibility testing and diagnostics, PK/PD analyses and dosing strategies, clinical outcome studies and case reports.
Dr. David Wareham
Guest Editor
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Keywords
- antimicrobials
- β-lactams
- β-lactamase inhibitors
- antimicrobial resistance
- epidemiology
- surveillance
- antimicrobial chemotherapy
- gram-negative infections
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