Host-Microbe Interactions in Clinically Relevant Acinetobacter spp.: New Models of Acinetobacter spp. Virulence and Its Interactions with Antibiotic Resistance

Dear Colleagues，

Acinetobacter spp. is a complex genus that comprises up to 50 species. The species pathogenic for human cause nosocomial infections such as pneumonia and bacteremia. The most important determinant in clinical outcome of Acinetobacter infections is antibiotic resistance. The role of resistance in affecting intrinsic virulence is complex. Several virulence models have been developed for the study of Acinetobacter infections. Almost all of these models are tested in the absence of antibiotics, so the results and conclusions obtained show the weakness of not reproducing the reality of the clinical picture of an infected patient, who is treated with antibiotics from the moment Acinetobacter spp. is identified as causative agent of infection. Therefore, a limitation of current models of virulence and infection are that they are not performed in the presence of antibiotics and do not account for antibiotic treatment when assessing an organism’s virulence potential. 

This Special Issue invites the submission of articles in which all types of Acinetobacter spp infection models are tested in the presence of the first- or second-line antibiotics most used to treat these infections.

Dr. Jesús Navas
Guest Editor

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