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Antibiotics
Special Issues
Antimicrobial Activity of Medical Materials
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Antimicrobial Activity of Medical Materials

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Materials and Surfaces".

Deadline for manuscript submissions: closed (15 June 2022) | Viewed by 30090

Special Issue Editor

Dr. Catherine Mullié

E-Mail Website
Guest Editor
Laboratoire Agents Infectieux, Résistance et chimiothérapie – AGIR - UR UPJV 4294, Faculté de Pharmacie, 1 rue des Louvels, 80037 Amiens CEDEX 1, France
Interests: hygiene; hospital associated infections; antimicrobial surfaces; copper alloys; multidrug resistant bacteria; efflux pumps; Pseudomonas aeruginosa; Acinetobacter baumannii

Special Issue Information

Dear Colleagues,

Infectious diseases can be transmitted either directly from person to person or indirectly via surfaces on which bacteria can survive and sometimes thrive as biofilms. On medical devices, formation of biofilms is an additional cause of chronic infections, sometimes leading to implant failure or patient death. Moreover, in hospital settings, both environmental- and medical device-mediated hospital associated infections (HAIs) are of great concern because they most of the time involve multi-drug resistant strains.

Therefore, to try and reduce medical device- and surface-associated infections, many alternatives have been proposed over the years, including the development of “self-sanitizing” surfaces or biomaterials. Such surfaces/biomaterials would indeed be a great help in trying to reduce HAIs, whether arising from medical devices or environmental contamination. Depending on the final purpose of the biomaterial, investigated alternatives include copper alloys, silver nanoparticles, specialized or functionalized polymers with either antibiotics, antimicrobial peptides or essential oils, etc.

The need for such materials and surfaces is obvious and the possibilities are numerous. This Special Issue of Antibiotics therefore welcomes review and research papers touching on any of these antimicrobial medical devices/surfaces as well as on the various methods and preclinical and clinical trials developed to assess their efficiency.

Dr. Catherine Mullié
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial surfaces
  • copper
  • silver
  • surface functionalization/modifications
  • biofilm prevention
  • medical textiles
  • efficiency

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Published Papers (7 papers)

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Research

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18 pages, 11034 KiB  
Article
Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil
by Pablo Edmundo Antezana, Sofia Municoy, Claudio Javier Pérez and Martin Federico Desimone
Antibiotics 2021, 10(11), 1420; https://doi.org/10.3390/antibiotics10111420 - 20 Nov 2021
Cited by 31 | Viewed by 4753
Abstract
Wounds represent a major healthcare problem especially in hospital-associated infections where multi-drug resistant strains are often involved. Nowadays, biomaterials with therapeutic molecules play an active role in wound healing and infection prevention. In this work, the development of collagen hydrogels loaded with silver [...] Read more.
Wounds represent a major healthcare problem especially in hospital-associated infections where multi-drug resistant strains are often involved. Nowadays, biomaterials with therapeutic molecules play an active role in wound healing and infection prevention. In this work, the development of collagen hydrogels loaded with silver nanoparticles and Cannabis sativa oil extract is described. The presence of the silver nanoparticles gives interesting feature to the biomaterial such as improved mechanical properties or resistance to collagenase degradation but most important is the long-lasting antimicrobial effect. Cannabis sativa oil, which is known for its anti-inflammatory and analgesic effects, possesses antioxidant activity and successfully improved the biocompatibility and also enhances the antimicrobial activity of the nanocomposite. Altogether, these results suggest that this novel nanocomposite biomaterial is a promising alternative to common treatments of wound infections and wound healing. Full article
(This article belongs to the Special Issue Antimicrobial Activity of Medical Materials)
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20 pages, 4878 KiB  
Article
In Vitro Microbiological and Drug Release of Silver/Ibuprofen Loaded Wound Dressing Designed for the Treatment of Chronically Infected Painful Wounds
by Alejandra Mogrovejo-Valdivia, Mickael Maton, Maria Jose Garcia-Fernandez, Nicolas Tabary, Feng Chai, Christel Neut, Bernard Martel and Nicolas Blanchemain
Antibiotics 2021, 10(7), 805; https://doi.org/10.3390/antibiotics10070805 - 2 Jul 2021
Cited by 6 | Viewed by 3147
Abstract
This study consisted of developing a dressing loaded with silver (Ag) and ibuprofen (IBU) that provides a dual therapy, antibacterial and antalgic, intended for infected painful wounds. Therefore, non-woven polyethyleneterephtalate (PET) textiles nonwovens were pre-treated by cyclodextrin crosslinked with citric acid by a [...] Read more.
This study consisted of developing a dressing loaded with silver (Ag) and ibuprofen (IBU) that provides a dual therapy, antibacterial and antalgic, intended for infected painful wounds. Therefore, non-woven polyethyleneterephtalate (PET) textiles nonwovens were pre-treated by cyclodextrin crosslinked with citric acid by a pad/dry/cure process. Then, textiles were impregnated in silver solution followed by a thermal treatment and were then coated by Layer-by-Layer (L-b-L) deposition of a polyelectrolyte multilayer (PEM) system consisting of anionic water-soluble poly(betacyclodextrin citrate) (PCD) and cationic chitosan. Finally, ibuprofen lysinate (IBU-L) was loaded on the PEM coating. We demonstrated the complexation of IBU with native βCD and PCD by phase solubility diagram and 1H NMR. PEM system allowed complete IBU-L release in 6 h in PBS pH 7.4 batch (USP IV). On the other hand, microbiological tests demonstrated that loaded silver induced bacterial reduction of 4 Log10 against S. aureus and E. coli and tests revealed that ibuprofen lysinate loading did not interfere with the antibacterial properties of the dressing. Full article
(This article belongs to the Special Issue Antimicrobial Activity of Medical Materials)
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Review

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24 pages, 1190 KiB  
Review
Current Knowledge on Biomaterials for Orthopedic Applications Modified to Reduce Bacterial Adhesive Ability
by Valeria Allizond, Sara Comini, Anna Maria Cuffini and Giuliana Banche
Antibiotics 2022, 11(4), 529; https://doi.org/10.3390/antibiotics11040529 - 15 Apr 2022
Cited by 28 | Viewed by 4442
Abstract
A significant challenge in orthopedics is the design of biomaterial devices that are able to perform biological functions by substituting or repairing various tissues and controlling bone repair when required. This review presents an overview of the current state of our recent research [...] Read more.
A significant challenge in orthopedics is the design of biomaterial devices that are able to perform biological functions by substituting or repairing various tissues and controlling bone repair when required. This review presents an overview of the current state of our recent research into biomaterial modifications to reduce bacterial adhesive ability, compared with previous reviews and excellent research papers, but it is not intended to be exhaustive. In particular, we investigated biomaterials for replacement, such as metallic materials (titanium and titanium alloys) and polymers (ultra-high-molecular-weight polyethylene), and biomaterials for regeneration, such as poly(ε-caprolactone) and calcium phosphates as composites. Biomaterials have been designed, developed, and characterized to define surface/bulk features; they have also been subjected to bacterial adhesion assays to verify their potential capability to counteract infections. The addition of metal ions (e.g., silver), natural antimicrobial compounds (e.g., essential oils), or antioxidant agents (e.g., vitamin E) to different biomaterials conferred strong antibacterial properties and anti-adhesive features, improving their capability to counteract prosthetic joint infections and biofilm formation, which are important issues in orthopedic surgery. The complexity of biological materials is still far from being reached by materials science through the development of sophisticated biomaterials. However, close interdisciplinary work by materials scientists, engineers, microbiologists, chemists, physicists, and orthopedic surgeons is indeed necessary to modify the structures of biomaterials in order to achieve implant integration and tissue regeneration while avoiding microbial contamination. Full article
(This article belongs to the Special Issue Antimicrobial Activity of Medical Materials)
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25 pages, 1358 KiB  
Review
Antimicrobial Peptides and Their Applications in Biomedical Sector
by Afreen Sultana, Hongrong Luo and Seeram Ramakrishna
Antibiotics 2021, 10(9), 1094; https://doi.org/10.3390/antibiotics10091094 - 10 Sep 2021
Cited by 24 | Viewed by 5030
Abstract
In a report by WHO (2014), it was stated that antimicrobial resistance is an arising challenge that needs to be resolved. This resistance is a critical issue in terms of disease or infection treatment and is usually caused due to mutation, gene transfer, [...] Read more.
In a report by WHO (2014), it was stated that antimicrobial resistance is an arising challenge that needs to be resolved. This resistance is a critical issue in terms of disease or infection treatment and is usually caused due to mutation, gene transfer, long-term usage or inadequate use of antimicrobials, survival of microbes after consumption of antimicrobials, and the presence of antimicrobials in agricultural feeds. One of the solutions to this problem is antimicrobial peptides (AMPs), which are ubiquitously present in the environment. These peptides are of concern due to their special mode of action against a wide spectrum of infections and health-related problems. The biomedical field has the highest need of AMPs as it possesses prominent desirable activity against HIV-1, skin cancer, breast cancer, in Behcet’s disease treatment, as well as in reducing the release of inflammatory cells such as TNFα, IL-8, and IL-1β, enhancing the production of anti-inflammatory cytokines such as IL-10 and GM-CSF, and in wound healing properties. This review has highlighted all the major functions and applications of AMPs in the biomedical field and concludes the future potential of AMPs. Full article
(This article belongs to the Special Issue Antimicrobial Activity of Medical Materials)
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16 pages, 2310 KiB  
Review
Effectiveness of Antibacterial Surfaces in Osseointegration of Titanium Dental Implants: A Systematic Review
by Nansi López-Valverde, Bruno Macedo-de-Sousa, Antonio López-Valverde and Juan Manuel Ramírez
Antibiotics 2021, 10(4), 360; https://doi.org/10.3390/antibiotics10040360 - 28 Mar 2021
Cited by 18 | Viewed by 4096
Abstract
Titanium (Ti) dental implant failure as a result of infection has been established at 40%, being regarded as one of the most habitual and untreatable problems. Current research is focused on the design of new surfaces that can generate long-lasting, infection-free osseointegration. The [...] Read more.
Titanium (Ti) dental implant failure as a result of infection has been established at 40%, being regarded as one of the most habitual and untreatable problems. Current research is focused on the design of new surfaces that can generate long-lasting, infection-free osseointegration. The purpose of our study was to assess studies on Ti implants coated with different antibacterial surfaces, assessing their osseointegration. The PubMed, Web of Science and Scopus databases were electronically searched for in vivo studies up to December 2020, selecting six studies that met the inclusion criteria. The quality of the selected studies was assessed using the ARRIVE (Animal Research: Reporting of In Vivo Experiments) criteria and Systematic Review Center for Laboratory animal Experimentation’s (SYRCLE’s) risk of bias tool. Although all the included studies, proved greater osseointegration capacity of the different antibacterial surfaces studied, the methodological quality and experimental models used in some of them make it difficult to draw predictable conclusions. Because of the foregoing, we recommend caution when interpreting the results obtained. Full article
(This article belongs to the Special Issue Antimicrobial Activity of Medical Materials)
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22 pages, 892 KiB  
Review
Brass Alloys: Copper-Bottomed Solutions against Hospital-Acquired Infections?
by Emilie Dauvergne and Catherine Mullié
Antibiotics 2021, 10(3), 286; https://doi.org/10.3390/antibiotics10030286 - 10 Mar 2021
Cited by 16 | Viewed by 4848
Abstract
Copper has been used for its antimicrobial properties since Antiquity. Nowadays, touch surfaces made of copper-based alloys such as brasses are used in healthcare settings in an attempt to reduce the bioburden and limit environmental transmission of nosocomial pathogens. After a brief history [...] Read more.
Copper has been used for its antimicrobial properties since Antiquity. Nowadays, touch surfaces made of copper-based alloys such as brasses are used in healthcare settings in an attempt to reduce the bioburden and limit environmental transmission of nosocomial pathogens. After a brief history of brass uses, the various mechanisms that are thought to be at the basis of brass antimicrobial action will be described. Evidence shows that direct contact with the surface as well as cupric and cuprous ions arising from brass surfaces are instrumental in the antimicrobial effectiveness. These copper ions can lead to oxidative stress, membrane alterations, protein malfunctions, and/or DNA damages. Laboratory studies back up a broad spectrum of activity of brass surfaces on bacteria with the possible exception of bacteria in their sporulated form. Various parameters influencing the antimicrobial activity such as relative humidity, temperature, wet/dry inoculation or wear have been identified, making it mandatory to standardize antibacterial testing. Field trials using brass and copper surfaces consistently report reductions in the bacterial bioburden but, evidence is still sparse as to a significant impact on hospital acquired infections. Further work is also needed to assess the long-term effects of chemical/physical wear on their antimicrobial effectiveness. Full article
(This article belongs to the Special Issue Antimicrobial Activity of Medical Materials)
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Other

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12 pages, 618 KiB  
Systematic Review
In Vivo Antibacterial Efficacy of Nanopatterns on Titanium Implant Surface: A Systematic Review of the Literature
by Yang Sun, Yang Yang, Weibo Jiang, Haotian Bai, He Liu and Jincheng Wang
Antibiotics 2021, 10(12), 1524; https://doi.org/10.3390/antibiotics10121524 - 14 Dec 2021
Cited by 6 | Viewed by 2820
Abstract
Background: Bionic surface nanopatterns of titanium (Ti) materials have excellent antibacterial effects in vitro for infection prevention. To date, there is a lack of knowledge about the in vivo bactericidal outcomes of the nanostructures on the Ti implant surfaces. Methods: A systematic review [...] Read more.
Background: Bionic surface nanopatterns of titanium (Ti) materials have excellent antibacterial effects in vitro for infection prevention. To date, there is a lack of knowledge about the in vivo bactericidal outcomes of the nanostructures on the Ti implant surfaces. Methods: A systematic review was performed using the PubMed, Embase, and Cochrane databases to better understand surface nanoscale patterns’ in vivo antibacterial efficacy. The inclusion criteria were preclinical studies (in vivo) reporting the antibacterial activity of nanopatterns on Ti implant surface. Ex vivo studies, studies not evaluating the antibacterial activity of nanopatterns or surfaces not modified with nanopatterns were excluded. Results: A total of five peer-reviewed articles met the inclusion criteria. The included studies suggest that the in vivo antibacterial efficacy of the nanopatterns on Ti implants’ surfaces seems poor. Conclusions: Given the small number of literature results, the variability in experimental designs, and the lack of reporting across studies, concluding the in vivo antibacterial effectiveness of nanopatterns on Ti substrates’ surfaces remains a big challenge. Surface coatings using metallic or antibiotic elements are still practical approaches for this purpose. High-quality preclinical data are still needed to investigate the in vivo antibacterial effects of the nanopatterns on the implant surface. Full article
(This article belongs to the Special Issue Antimicrobial Activity of Medical Materials)
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