Peptide-Based Antibiotics: Challenges and Opportunities
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Peptides".
Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 27298
Special Issue Editors
Interests: antimicrobial peptides; drug delivery
Special Issues, Collections and Topics in MDPI journals
Interests: antimicrobial peptides; immunomodulation; drug delivery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Antimicrobial resistance is one of the most imminent threats to public health. There is a critical unmet need for novel antibiotics capable of killing multidrug-resistant bacteria. AMPs are a part of the innate immune system of all living organisms and typically exhibit broad-spectrum activity against Gram-positive and Gram-negative bacteria. Furthermore, AMPs display a wide range of immunomodulatory properties. Compared to traditional antibiotics, AMPs appear to have a lower propensity to select for resistant strains. However, natural AMPs are potentially toxic and rapidly degraded by proteases with an ensuing low bioavailability. The stability of AMPs can typically be improved by chemical modification such as lipidation, cyclization, or the insertion of non-standard building blocks, including D-amino acids or peptoids. Alternatively, peptidomimetics (i.e., oligomers with a backbone that is not entirely based on α-amino acid residues) such as α-peptide/β-peptides, α-peptides/α-peptoids, or α-peptide/β-peptoids are very promising. Other interesting approaches are peptoids, AMP dendrimers, peptide–antibiotic conjugates, and peptidomimetics for the repurposing of antibiotics against multidrug-resistant pathogens.
Although the field of peptide-based antibiotics has developed tremendously over the last two decades (e.g., by improved design, mechanistic understanding, formulation, and delivery), therapeutic breakthroughs for the systemic treatment of bacterial infections remain to be achieved.
For this Special Issue entitled ”Peptide-Based Antibiotics: Challenges and Opportunities”, we invite authors to submit articles covering all aspects of this theme.
Prof. Paul Robert Hansen
Prof. Dr. Henrik Franzyk
Guest Editors
Manuscript Submission Information
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Keywords
- antimicrobial peptides
- drug delivery
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