Novel Antiprotozoal Drug Formulations and Treatments
A special issue of Antibiotics (ISSN 2079-6382).
Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 9096
Special Issue Editors
Interests: sustainable chemistry; ionic liquids; drug delivery
Special Issues, Collections and Topics in MDPI journals
Interests: sustainable chemistry; ionic liquids; catalysis; material science; responsive materials; energy; pharmaceuticals
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Protozoan parasites such as Plasmodium spp., Trypanosoma spp. and Leishmania spp. are responsible for diseases that cause significant mortality, morbidity and economic burden, predominantly in developing countries. The life-threatening diseases they provoke, including leishmaniasis, malaria, Chagas disease and human African trypanosomiasis (HAT), are considered some of the most challenging infectious diseases due to their limited therapeutic options and high mortality rates. There are currently no effective vaccines against these diseases, and new antiprotozoals are urgently required as most existing drugs suffer from poor efficacy, drug resistance, toxicity, high costs, poor stability and solubility as well as other pharmacokinetic properties. Therefore, the treatment of malaria, human African trypanosomiasis (HAT), Chagas disease and leishmaniasis relies heavily on new drug discovery and the development of novel effective, safe and inexpensive antiprotozoal treatments. Consequently, studies on the synthesis and evaluation of new drugs with increased antiprotozoal efficiency (fewer drawbacks, better bioavailability and less long-term toxicity), mechanisms of action, drug delivery and formulation, combination and therapy delivery remain crucial for the development of new antiprotozoal treatments. Given this context, this Special Issue aims to gather review papers and original research articles dealing with the potential antiprotozoal activities of novel drug candidates, modes of action and drug formulations. We welcome contributions on the following topics: synthesis and evaluation of the antiprotozoal activity of new compounds; the preparation and evaluation of drug formulations; combination therapy of antiprotozoal drugs and other substances; in vitro and in vivo evaluation; mechanisms of action; and drug resistance.
Dr. Željko Petrovski
Dr. Luis Cobra Branco
Guest Editors
Manuscript Submission Information
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Keywords
- antiprotozoal activity and treatment
- drug formulations
- mechanism of action and resistance to antiprotozoal drugs
- combination therapy
- malaria
- human African trypanosomiasis (HAT)
- Chagas disease
- leishmaniasis
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