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Antibiotics
Special Issues
Nanocarriers for Antibacterial Delivery
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Nanocarriers for Antibacterial Delivery

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 7899

Special Issue Editor

Dr. José Rubén Morones-Ramírez

E-Mail Website
Guest Editor
Facultad de Ciencias Químicas, Universidad Autónoma de Nuevo León, UANL, San Nicolás de los Garza, Mexico
Interests: Antimicrobial Therapies; nanomaterials; antibiotic resistance
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The clinical failure of antibacterial therapy is linked to low bioavailability, poor penetration to bacterial infection sites, the side effects of antibacterial drugs, and the antibacterial resistance properties of bacteria. Therefore, there is an urgent need to design novel antibacterial agents and new antibacterial materials and coatings. Nanocarriers include nanoparticles, dendrimers, carbon nanotubes, and polymer conjugates or lipid-based carriers such as liposomes. They offer several advantages over free drugs since they improve drug efficacy by encapsulating hydrophobic drugs within the core of the nanocarriers. They can protect the drug from premature degradation, inhibit premature interaction of drug with the biological environment, improve cellular penetration, control pharmacokinetic and drug tissue distribution profile, enhance absorption of the drug in a given tissue, and reduce antimicrobial resistance. These properties can be applied to facilitate the administration of antimicrobial drugs, thereby overcoming some limitations in traditional antimicrobial therapeutics. This Special Issue is also linked to the International Congress on NanoBioEngineering 2022, organized by the Research Center on Biotechnology and Nanotechnology (CIByN) at the School of Chemical Sciences at the Universidad Autonoma de Nuevo Leon (UANL). Thus, this Special Issue welcomes the submission of original research, reviews, short communications, case reports, etc., offering novel therapeutic alternatives to face antibiotic resistance using nanocarriers as delivery systems.

Dr. José Rubén Morones-Ramírez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanotechnology
  • nanocarriers
  • antibiotic resistance
  • antibacterial agent design
  • antibiotic delivery

Published Papers (2 papers)

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Research

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17 pages, 4141 KiB  
Article
Ultra-Small Silver Nanoparticles: A Sustainable Green Synthesis Approach for Antibacterial Activity
by Javier Emanuel Castañeda-Aude, José Rubén Morones-Ramírez, David Alejandro De Haro-Del Río, Angel León-Buitimea, Enrique Díaz Barriga-Castro and Carlos Enrique Escárcega-González
Antibiotics 2023, 12(3), 574; https://doi.org/10.3390/antibiotics12030574 - 14 Mar 2023
Cited by 9 | Viewed by 2923
Abstract
The present study centers on the synthesis of ultra-small silver nanoparticles (AgNPs) with antibacterial properties using citrus peel residues (orange, lemon, and grapefruit) as reducing and stabilizing agents, and on assessing their antibacterial activity against multidrug-resistant clinical Staphylococcus aureus. The synthesized AgNPs [...] Read more.
The present study centers on the synthesis of ultra-small silver nanoparticles (AgNPs) with antibacterial properties using citrus peel residues (orange, lemon, and grapefruit) as reducing and stabilizing agents, and on assessing their antibacterial activity against multidrug-resistant clinical Staphylococcus aureus. The synthesized AgNPs were analyzed by various techniques, including UV-Vis spectroscopy, SAED, TEM, XRD, FTIR, and Raman. The results demonstrate the formation of ultra-small, monodisperse, quasi-spherical AgNPs with an average particle size of 2.42 nm for AgNPs produced with mixed extracts. XRD analysis indicated that the AgNPs have a crystal size of 9.71 to 16.23 nm. The AgNPs exhibited potent inhibitory activity against resistant S. aureus, with a minimum inhibitory concentration (MIC) of 15.625 to 62.50 ppm. The findings suggest that the ultra-small nanometer size of the AgNPs could be attributed to the synthesis method that employs ambient conditions and the presence of polyphenolic compounds from citrus peel. Consequently, AgNPs obtained through sustainable green synthesis hold significant potential in combating clinical multi-resistant bacterial strains that are challenging to treat and eradicate. This approach also contributes to the revaluation of citrus residues in the region, which is an ongoing environmental issue today. Full article
(This article belongs to the Special Issue Nanocarriers for Antibacterial Delivery)
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Review

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34 pages, 1365 KiB  
Review
Nanomaterials-Based Combinatorial Therapy as a Strategy to Combat Antibiotic Resistance
by Angel León-Buitimea, Cesar R. Garza-Cárdenas, María Fernanda Román-García, César Agustín Ramírez-Díaz, Martha Ulloa-Ramírez and José Rubén Morones-Ramírez
Antibiotics 2022, 11(6), 794; https://doi.org/10.3390/antibiotics11060794 - 12 Jun 2022
Cited by 12 | Viewed by 3968
Abstract
Since the discovery of antibiotics, humanity has been able to cope with the battle against bacterial infections. However, the inappropriate use of antibiotics, the lack of innovation in therapeutic agents, and other factors have allowed the emergence of new bacterial strains resistant to [...] Read more.
Since the discovery of antibiotics, humanity has been able to cope with the battle against bacterial infections. However, the inappropriate use of antibiotics, the lack of innovation in therapeutic agents, and other factors have allowed the emergence of new bacterial strains resistant to multiple antibiotic treatments, causing a crisis in the health sector. Furthermore, the World Health Organization has listed a series of pathogens (ESKAPE group) that have acquired new and varied resistance to different antibiotics families. Therefore, the scientific community has prioritized designing and developing novel treatments to combat these ESKAPE pathogens and other emergent multidrug-resistant bacteria. One of the solutions is the use of combinatorial therapies. Combinatorial therapies seek to enhance the effects of individual treatments at lower doses, bringing the advantage of being, in most cases, much less harmful to patients. Among the new developments in combinatorial therapies, nanomaterials have gained significant interest. Some of the most promising nanotherapeutics include polymers, inorganic nanoparticles, and antimicrobial peptides due to their bactericidal and nanocarrier properties. Therefore, this review focuses on discussing the state-of-the-art of the most significant advances and concludes with a perspective on the future developments of nanotherapeutic combinatorial treatments that target bacterial infections. Full article
(This article belongs to the Special Issue Nanocarriers for Antibacterial Delivery)
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