Role of Nrf2 and ROS in Bone Metabolism

Dear Colleagues,

Bone metabolism is regulated by the balance between bone formation and resorption. In recent years, it has become evident that oxidative stress, including the activities of reactive oxygen species (ROS), plays a crucial role in the regulation of  bone metabolism. For example, osteoclasts utilize intracellular ROS signaling after RANKL. 

In addition, Nrf2 (nuclear factor erythroid 2-related factor 2) is a key transcription factor that regulates the expression of antioxidant proteins and plays a crucial role in maintaining cellular redox homeostasis. Recent studies have shown that Nrf2 is involved in the regulation of bone metabolism via the modulation of the differentiation and function of osteoblasts and osteoclasts.

Moreover, the interplay between ROS and Nrf2 signaling pathways has been implicated in various bone disorders such as osteoporosis, osteoarthritis, periodontitis, and the healing of bone fractures. Understanding the molecular mechanisms that underlie the regulation of bone metabolism by ROS and Nrf2 could provide new insights into the pathogenesis of these bone disorders and lead to the development of novel therapeutic strategies.

This Special Issue aims to gather original research articles, reviews, and short communications that explore the role of Nrf2 and ROS in bone metabolism. Topics of interest include, but are not limited to, the following:

• Molecular mechanisms of Nrf2 and ROS signaling in osteoblast and osteoclast differentiation and function;
• Nrf2 and ROS in bone disorders such as osteoporosis, osteoarthritis, periodontitis, and bone fracture healing;
• Crosstalk between Nrf2 and other signaling pathways in bone metabolism;
• Antioxidant therapies targeting Nrf2 and ROS for the treatment of bone disorders;
• Novel experimental models and techniques to study the role of Nrf2 and ROS in bone metabolism.

We invite researchers from various fields, including bone biology, redox biology, and molecular biology, to contribute to this Special Issue and share their latest findings and perspectives on the role of Nrf2 and ROS in bone metabolism.

Dr. Hiroyuki Kanzaki
Guest Editor

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• bone metabolism
• reactive oxygen species (ROS)
• oxidative stress
• osteoblast
• osteoclast
• inflammation
• Nrf2
• Keap1
• Bach1
• FOXOs
• sirtuins
• anti-oxidation
• osteoporosis
• osteoarthritis
• bone fracture healing