NO and ROS in Redox Signalling

Dear Colleagues,

Nitric oxide (NO) and reactive oxygen species (ROS) superoxide, hydrogen peroxide, and to a lesser extent hydroxyl radical and singlet oxygen regulate a myriad of physiological processes required for the health of organisms.  Our goal in this Special Issue is to present the state of the art on pathways, either physio-pathological or alternative ones, regulating oxidative stress.

NO and ROS can be generated by a variety of oxydoreductases or hemoglobins that, depending on levels of NO or molecular oxygen, can produce either protective or pathological levels of NO or ROS.  Moreover, alternative pathways for producing NO from nitrite or nitrate via various hemoproteins can increase the levels of NO whenever needed under hypoxic conditions. Activators of soluble guanylate cyclase can also improve normal signaling. Additional activities of some hemoproteins to generate ROS by enzymatic decoupling (mitochondrial enzymes, NOS enzymes) or decrease ROS through an increased SOD activity, as recently shown for cytoglobin, will also enhance pathological conditions or reduce oxidative stress.

The goal in redox signaling research is to gain an understanding of the molecular events that underlie the critical point at which the interplay between NO and ROS levels leads to either a physiological or pathological response.  Such studies require the precise and direct measurement of very low levels of NO and ROS during their transient fluxes in vivo.

This Special Issue of Antioxidants invites researchers who are at the forefront of utilizing chemical tools coupled to physical techniques for the intravital determination of NO and/or ROS levels for the elucidation of redox signaling pathways.

Prof. Dr. Bulent Mutus
Dr. Anny Slama-Schwok
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the Special Issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.