Antioxidants in Cosmetics

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 1349

Special Issue Editors


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Guest Editor

E-Mail Website
Guest Editor
Department of Pharmacy, School of Health Sciences, University of Patras, 26504 Patras, Greece
Interests: pharmacognosy and chemistry of natural products

Special Issue Information

Dear Colleagues,

Herbal extracts and protein hydrolysates have long been utilized in traditional medicine and dermatology for promoting skin health, accelerating wound healing, and treating minor burns and irritations. In recent years, there has been a growing interest in incorporating herbal extracts, isolated natural products, and bioactive peptides into cosmetic formulations due to their broad spectrum of biological activities on the skin. Among these, their antioxidant activity stands out as a key mechanism through which these agents exert their protective and restorative effects.

Oxidative stress, which is driven by an imbalance between reactive oxygen species (ROS) and the skin's antioxidant defense system, plays a central role in skin ageing and inflammatory conditions. It is often triggered by both extrinsic (e.g., ultraviolet radiation and environmental pollutants) and intrinsic (e.g., chronological ageing and metabolic processes) factors. By neutralizing ROS and modulating cellular antioxidant pathways, natural antioxidants and peptides can contribute significantly to maintaining skin integrity and delaying the signs of ageing.

This Special Issue aims to gather cutting-edge research and reviews on the antioxidant properties of natural products and peptides, with particular emphasis on their application in cosmetic science to promote skin health and beauty. We welcome submissions exploring mechanistic insights, formulation development, efficacy and safety evaluations, and novel sources and procedures for the production/isolation of bioactive compounds. The use of herbal extracts and essential oils falls within the scope of this Special Issue, provided that an adequate chromatographic/spectroscopic characterization is presented.

Prof. Dr. Fotini Lamari
Dr. Vassiliki Magafa
Dr. Sophia Hatziantoniou
Guest Editors

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Keywords

  • cosmetics
  • herbal extracts
  • natural products
  • peptides
  • synthesis
  • isolation
  • oxidative stress
  • emulsions
  • nanoparticles
  • fibroblasts
  • ageing

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Published Papers (1 paper)

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Research

14 pages, 1195 KB  
Article
Natural Bioactive Peptides from Tree Peony Flowers: Multifunctional Effects on Skin Antioxidation, Wrinkle Reduction, Moisturization, and Melanin Inhibition
by Yunzong Liu, Ruofei Zheng, Linyue Zhong, Junyang Huang, Xuefang Guan, Juqing Huang, Mei Xu, Yafeng Zheng and Qi Wang
Antioxidants 2026, 15(3), 350; https://doi.org/10.3390/antiox15030350 - 11 Mar 2026
Viewed by 807
Abstract
The edible tree peony (Paeonia suffruticosa Andrews) flowers are rich in bioactive components with potential health benefits, but the skin-health-promoting effects of their protein hydrolysates remain understudied. The present research sought to evaluate the antioxidant, anti-wrinkle, moisturizing, and whitening properties of tree [...] Read more.
The edible tree peony (Paeonia suffruticosa Andrews) flowers are rich in bioactive components with potential health benefits, but the skin-health-promoting effects of their protein hydrolysates remain understudied. The present research sought to evaluate the antioxidant, anti-wrinkle, moisturizing, and whitening properties of tree peony flower protein hydrolysate (TPFP). TPFP was prepared via enzymatic hydrolysis and ultrafiltration, and its peptide sequences were identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS), revealing 54 unique small-molecule peptides with an average amino acid length of 8.2 residues and a molecular weight of 914.51 Da. In vitro safety evaluation using CCK-8 assay showed TPFP (20–100 μM) did not induce substantial cytotoxic effects in either HaCaT keratinocytes or B16F10 melanoma cell lines. Functional assays demonstrated that TPFP dose-dependently inhibited UVB-induced reactive oxygen species (ROS) overproduction and restored superoxide dismutase (SOD) and catalase (CAT) activities in HaCaT cells, exerting antioxidant effects. Additionally, TPFP protected pro-collagen I from UVB-induced loss, suppressed the expression of matrix metalloproteinase 1 (MMP-1), and restored hyaluronic acid (HA) content, showing anti-wrinkle and moisturizing potentials. In α-MSH-stimulated B16F10 cells, TPFP suppressed melanin synthesis by downregulating the protein expression of tyrosinase (TYR), tyrosinase-related protein 1 (TRP-1), and TRP-2, achieving a whitening effect. These findings indicate that TPFP possesses comprehensive skin-health-promoting activities with good biocompatibility, highlighting its potential as a natural functional ingredient in cosmetics and functional foods. Full article
(This article belongs to the Special Issue Antioxidants in Cosmetics)
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