Oxidative and Nitrosative Stress in Male Reproduction
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 732
Special Issue Editors
Interests: andrology; reproductive biology; oxidative stress; nitrosative stress; sperm function; cell death
Special Issues, Collections and Topics in MDPI journals
Interests: reproductive medicine; andrology; reproductive physiopathology; oxidative stress; sperm function; sperm cryopreservation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Infertility is a highly prevalent disease, and oxidative stress significantly contributes to the aetiology of male infertility. Oxidative stress impairs sperm function, and a high percentage of infertile men display elevated levels of seminal reactive oxygen species (ROS) and reactive nitrogen species (RNS). Spermatozoa are highly vulnerable to oxidative stress, and detrimental damage associated with high levels of ROS can affect several biomolecules, including lipids, proteins and DNA. Oxidative and nitrosative damage affects all aspects of sperm function, and DNA oxidation and fragmentation caused by ROS have the potential to impact embryo development and the health and well-being of the offspring. Similarly, like ROS, reactive nitrogen species (RNS) produced at high levels during so-called nitrosative stress are also associated with male infertility. The exposure of spermatozoa to high levels of RNS results in impaired sperm function, as evidenced by the loss of quality and the decrease in crucial sperm functions, including motility and ATP production. The nitrosative damage can ultimately commit spermatozoa to cell death.
It is therefore evident that an underlying aetiology of male infertility is mediated by an impairment of sperm function as a consequence of cellular stress mediated by ROS and RNS. In light of these considerations, antioxidants may play a role in the preservation of reproductive function in men. This Special Issue invites investigators to submit original research, short communication and review articles to discuss the pivotal role of oxidative and nitrosative stress in different aspects of sperm function. We encourage contributions that describe the potential benefits of antioxidants as a means of improving sperm quality under conditions of oxidative and nitrosative stress.
Dr. Pamela Uribe
Dr. Raúl Sánchez
Guest Editors
Manuscript Submission Information
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Keywords
- oxidative stress
- nitrosative stress
- reactive oxygen species
- reactive nitrogen species
- spermatozoa
- sperm motility
- sperm function
- antioxidants
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