Mitochondrial Dysfunction and Immuno-Oxidative Stress in Neuropsychiatric Disorders

Dear Colleagues,

Evidence suggests that metabolic changes associated with immuno-oxidative pathway, including mitochondrial dysfunction, redox dysregulation, oxidative stress and neuroinflammation, play an important role in the pathophysiology of numerous neuropsychiatric diseases and aging-associated brain disorders. The interaction between these processes disrupts local neuronal circuits and leads to disconnection between distant brain regions, ultimately impairing information processing and affecting cognitive function. However, the molecular mechanisms and alternated metabolisms associated with these abnormalities, particularly in relation to immuno-oxidative pathways in the brains of neuropsychiatric patients, and the ways in which they change over time are not yet fully understood.

This Special Issue aims to cover the following topics:

1. The molecular mechanisms underlying immune-oxidative stress and the pathophysiological consequences in cellular and tissue function from bench study to bedside.
2. New avenues in therapeutic and drug development, with particular focus on the relationship between oxidative stress and/or the immune system in neuropsychiatric disorders such as schizophrenia, depression, Alzheimer’s disease, multiple sclerosis, and aging.
3. Identification of treatment-engaged targets that will help with the development of new therapeutic strategies.
4. Biomarkers of disease progression and treatment response, providing insight into monitoring and predicting patient outcomes.

Manuscripts that explore molecular targets within cellular systems and potential pharmacological strategies that can modulate immune-oxidative stress will also be considered. Review articles or original studies using animal or cell models, as well as clinical and neuroimaging studies, are welcome.

Authors are encouraged to submit work that sheds light on the intricate relationship between oxidative stress, immune system dysregulation, and the pathogenesis of neuropsychiatric disorders. This Special Issue aims to advance our understanding of these underlying mechanisms and explore novel therapeutic approaches that can alleviate the burden of these disorders.

Dr. Fei Du
Dr. Can Zhang
Dr. Jie Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• oxidative stress
• mitochondrial dysfunction
• neuroinflammation
• neuropsychiatric diseases
• aging