Antioxidants

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Prof. Dr. Yasuyoshi Watanabe

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Guest Editor

Graduate School of Science, Technology and Innovation, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan
Interests: biomarker

Special Issue Information

Dear Colleagues,

Oxidative stress induced by generation of excess reactive oxygen species during energy production for work or overwork results in the onset/trigger of a variety of diseases. To prevent the onset of almost all diseases, daily or scheduled intake of the antioxidant nutrients derived from water, food, and supplements is quite important. Among them, hydrogen-enriched water (HW) and electrolyzed hydrogen water (EHW) contain abundant molecular hydrogen (HW and EHW) and also very small amounts of platinum nanoparticles with alkaline properties in the case of EHW and has intense scavenging activity of antioxidants toward ROS in the cells and tissues. Daily intake, dialysis, and then watering of HW and EHW show beneficial effects on our healthy life fighting against the risk and also symptoms in the patients with the digestive, cardiovascular, endocrine/metabolism, renal, respiratory, immune, reproductive, and neuropsychatric diseases. Of course, not only in human and animal studies, but many studies with cultured cells, plants, and materials showed great power of HW and EHW for anti-oxidation to affect healthy cell growth, maintenance and elevation of their functions, prolongation of life span, and so forth. In this special issue, we would like to collect the excellent papers on the physicochemical properties, molecular mechanisms of the beneficial effects, effects on prevention from and treatment of a variety of diseases, effects on the endurance in sports and prevention of severe chronic fatigue, and unique application in the field of material science. Your contribution with comprehensive and cutting-edge study results will be greatly appreciated.

Prof. Dr. Yasuyoshi Watanabe
Guest Editor

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Keywords

hydrogen water
hydrogen enriched water
electrolyzed hydrogen water
electrolyzed hydrogen-enriched water
electrolyzed–reduced water
functional water
health
prevention from ahead-sich status
essential healthcare

Published Papers (2 papers)

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Research

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14 pages, 443 KiB

Open AccessArticle

Health Effects of Electrolyzed Hydrogen Water for the Metabolic Syndrome and Pre-Metabolic Syndrome: A 3-Month Randomized Controlled Trial and Subsequent Analyses

by Reiko Moribe, Marina Minami, Ryoji Hirota, Naw Awn J-P, Shigeru Kabayama, Masamitsu Eitoku, Keiko Yamasaki, Hajime Kuroiwa and Narufumi Suganuma

Antioxidants 2024, 13(2), 145; https://doi.org/10.3390/antiox13020145 - 24 Jan 2024

Viewed by 1778

Abstract

We studied the effect of three months’ use of electrolyzed hydrogen water (EHW, Electrolyzed Hydrogen Water conditioner produced by Nihon Trim Co., Ltd.) on metabolic and pre-metabolic syndrome groups. This research was carried out jointly by Susaki City; Nihon Trim Co., Ltd.; and Kochi University as part of a local revitalization project with health as a keyword. A randomized, placebo-controlled, double-blind, parallel-group trial was conducted to evaluate the clinical impact of EHW on participants who suffered from metabolic syndrome or pre-metabolic syndrome. EHW was produced via electrolysis using a commercially available apparatus (Nihon Trim Co., Ltd., Osaka, Japan). During exercise, oxidative stress increases, and active oxygen species increase. In this study, we examined 181 subjects with metabolic syndrome or pre-metabolic syndrome. Among the group that drank EHW for 3 months, those who also engaged in a high level of physical activity showed a significant difference in waist circumference reduction. Although no significant difference was observed, several positive results were found in the participants who engaged in a high level of physical activity. Urinary 8-OHdG, urinary nitrotyrosine, HbA1c, and blood glucose levels increased in the filtered water (FW) group but decreased in the EHW group. High-sensitivity CRP increased less in the EHW group. 8-Isoprostane decreased more in the EHW group. In subgroup analysis, the EHW group showed a significantly greater reduction in waist circumference than the FW group only when controlled for high physical activity. Based on the result, we suggest that, among participants in the study who suffered from metabolic syndrome and pre-metabolic syndrome in which the level of active oxygen species is said to be higher than in healthy subjects, the group that consumed EHW and also engaged in a high level of physical activity experienced a suppressed or reduced increase in active oxygen species. Full article

(This article belongs to the Special Issue Antioxidant and Anti-inflammatory Effects of Hydrogen-Enriched Water)

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Review

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16 pages, 1409 KiB

Open AccessReview

Application of Electrolyzed Hydrogen Water for Management of Chronic Kidney Disease and Dialysis Treatment—Perspective View

by Masaaki Nakayama, Shigeru Kabayama and Mariko Miyazaki

Antioxidants 2024, 13(1), 90; https://doi.org/10.3390/antiox13010090 - 11 Jan 2024

Viewed by 5462

Abstract

Chronic kidney disease (CKD), which is globally on the rise, has become an urgent challenge from the perspective of public health, given its risk factors such as end-stage renal failure, cardiovascular diseases, and infections. The pathophysiology of CKD, including dialysis patients, is deeply associated with enhanced oxidative stress in both the kidneys and the entire body. Therefore, the introduction of a safe and widely applicable antioxidant therapy is expected as a measure against CKD. Electrolyzed hydrogen water (EHW) generated through the electrolysis of water has been confirmed to possess chemical antioxidant capabilities. In Japan, devices producing this water have become popular for household drinking water. In CKD model experiments conducted to date, drinking EHW has been shown to suppress the progression of kidney damage related to hypertension. Furthermore, clinical studies have reported that systemic oxidative stress in patients undergoing dialysis treatment using EHW is suppressed, leading to a reduction in the incidence of cardiovascular complications. In the future, considering EHW as one of the comprehensive measures against CKD holds significant importance. The medical utility of EHW is believed to be substantial, and further investigation is warranted. Full article

(This article belongs to the Special Issue Antioxidant and Anti-inflammatory Effects of Hydrogen-Enriched Water)

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