Oxidative Stress in Respiratory Disorders

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 458

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Jesseniuss Faculty of Medicine, Martin, Slovakia
Interests: chronic respiratory diseases
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Dear Colleagues,

Oxidative stress is linked with various acute and chronic respiratory disorders. Abundant production of oxidants is responsible for the damage of a variety of biomolecules that subsequently triggers distinct pathological changes in the lung. Generation of reactive oxygen and nitrogen species plays an important role in inflammation, endothelial dysfunction, and fibrotic changes in the lung including lung damage due to hypoxia/hyperoxia, mechanical ventilation, etc. In addition to acute lung injury from various reasons including COVID-19, oxidative stress represents one of the fundamental factors in the pathogenesis of chronic respiratory disorders such as bronchial asthma, chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, or lung silicosis. Moreover, oxidative stress is of great importance in premature neonates in which the damage of immature lung tissue may cause bronchopulmonary dysplasia, pulmonary hypertension and other serious complications. Understanding the role of oxidative stress in respiratory diseases has led to the administration of various antioxidants, some of which have exerted very promising effects.

We invite you to submit your latest research findings or a review article to this Special Issue, which will bring together current research concerning the importance of oxidative stress in respiratory disorders and perspective treatments diminishing the oxidative lung damage. This research can include both in vitro and in vivo studies relating to any of the following topics: oxidative stress in acute lung injury; oxidative stress in chronic respiratory diseases (asthma, COPD, pulmonary fibrosis, lung silicosis etc.); oxidative stress in premature neonates; antioxidant treatment in respiratory diseases.

Dr. Daniela Mokra
Guest Editor

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Keywords

  • oxidative stress
  • lung
  • reactive oxygen species
  • reactive nitrogen species
  • acute lung injury
  • asthma
  • COPD
  • lung fibrosis
  • pulmonary silicosis
  • premature neonate

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Published Papers (1 paper)

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Research

15 pages, 270 KiB  
Article
Characterization of Systemic Oxidative Stress in Asthmatic Adults Compared to Healthy Controls and Its Association with the Oxidative Potential of Particulate Matter Collected Using Personal Samplers
by Miguel Santibáñez, Adriana Núñez-Robainas, Esther Barreiro, Andrea Expósito, Juan Agüero, Juan Luis García-Rivero, Beatriz Abascal, Carlos Antonio Amado, Juan José Ruiz-Cubillán, Carmen Fernández-Sobaler, María Teresa García-Unzueta, José Manuel Cifrián and Ignacio Fernandez-Olmo
Antioxidants 2025, 14(4), 385; https://doi.org/10.3390/antiox14040385 - 25 Mar 2025
Viewed by 233
Abstract
Inflammatory cell activation in asthma may lead to reactive oxygen species (ROS) overproduction with an imbalance between oxidant levels and antioxidant capacity, called oxidative stress (OS). Since particulate matter (PM) airborne exposure may also contribute to ROS generation, it is unclear whether PM [...] Read more.
Inflammatory cell activation in asthma may lead to reactive oxygen species (ROS) overproduction with an imbalance between oxidant levels and antioxidant capacity, called oxidative stress (OS). Since particulate matter (PM) airborne exposure may also contribute to ROS generation, it is unclear whether PM contributes more to OS than inflammatory cell activation. In our ASTHMA-FENOP study, which included 44 asthma patients and 37 matched controls, we aimed to characterize OS using five serum markers: total ROS content, protein carbonyl content, oxidized low-density lipoprotein (OxLDL), 8-hydroxydeoxyguanosine, and glutathione. Volunteers wore personal samplers for 24 h, collecting fine and coarse PM fractions separately, and the oxidative potential (OP) was determined using two methods. We observed differences between asthmatic and non-asthmatic volunteers in some OS markers, such as OxLDL, with an adjusted mean difference of 50,059.8 ng/mL (p < 0.001). However, we did not find an association between higher PM-OP and increased systemic OS. This suggests that at our PM-OP exposure levels, OS generated by the inflammatory cells themselves is more relevant than that generated by airborne PM. This supports the idea that asthma is a heterogeneous disease at the molecular level, mediated by inflammatory cell activation, and that OS may have potential clinical implications. Full article
(This article belongs to the Special Issue Oxidative Stress in Respiratory Disorders)
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