Antioxidants as Weapons to Maintain or Restore Oral Health

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 10 June 2025 | Viewed by 1487

Special Issue Editors


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Guest Editor
1. Associate Laboratory i4HB—Institute for Health and Bioeconomy, University Institute of Health Sciences—CESPU, 4585-116 Gandra, Portugal
2. ALiCE—Associate Laboratory in Chemical Engineering, Faculty of Engineering, LEPABE—Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Porto, Portugal
Interests: biofilms; Candida infections; AMR; polymicrobial infections; alternative treatments; natural compounds; oral infections
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Associate Laboratory i4HB-Institute for Health and Bioeconomy, University Institute of Health Sciences-CESPU, 4585-116 Gandra, Portugal
Interests: food biotechnology; functional foods; food nutrition; gut-health; probiotics; beneficial microorganims; bioactive fatty acids; polyphenols; microencapsulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Both the World Health Organization (WHO) and United Nations (UN) stress that oral diseases are among the most common non-communicable diseases, affecting around 3.5 billion people worldwide, with extremely high costs annually. This impacts patients’ oral and systemic health, and leads to the global rise in infections and antimicrobial resistance (AMR). Several pathogens can be involved in the development of oral health, but the disturbance of the oral microbiome is also a key factor. In particular, the main threats arise from pathogens of the genera Streptococcus, Lactobacillus, Actinomyces, Porphyromonas, Fusobacterium, Treponema and Enterococcus spp. It is known that AMR can arise in both planktonic (free) and biofilm cells, the latter being the main form of microbial growth. Indeed, biofilms pose a significant challenge in this context due to their protective nature and ability to harbor resistant microorganisms.

In this Special Issue, we would like to delve into various aspects, including the specific challenges resistance poses in treatment, and the development and testing of new antioxidants targeting biofilms. Highlighting research on compounds that demonstrate effectiveness against both biofilm-associated infections and resistant strains would be particularly valuable. Additionally, due to the interdisciplinary nature of this Special Issue, we will include perspectives from microbiology, (ethno)pharmacology and biomaterials science, which can provide a comprehensive understanding and antioxidants’ potential solutions in medical and non-medical settings, pursuant to offer insights into preventive measures. Overall, this Special Issue aims to contribute significantly to the ongoing efforts in combating AMR, preventing and improving treatment outcomes for microbial infections using current and novel antioxidant compounds.

Dr. Célia Fortuna Rodrigues
Dr. José Carlos Andrade
Guest Editors

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Keywords

  • polyphenols
  • biofilms
  • oral mucositis
  • gingivitis
  • caries
  • AMR

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Published Papers (1 paper)

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Research

12 pages, 1591 KiB  
Article
Modulatory Effects of Photobiomodulation on Oxidative and Inflammatory Responses in a Murine Model of Periodontitis
by Larissa Trarbach Figueiredo Braga, Isadora Martins Ribeiro, Maria Eduarda de Souza Barroso, Edgar Hell Kampke, Lorena Nascimento Santos Neves, Sara Cecília Andrade, Guilherme Heleodoro Barbosa, Marcella Leite Porto and Silvana Santos Meyrelles
Antioxidants 2024, 13(12), 1450; https://doi.org/10.3390/antiox13121450 - 26 Nov 2024
Viewed by 915
Abstract
Periodontitis, an oral disease initiated by a dysbiotic dental biofilm, has an unclear response to photobiomodulation (PBM) as an adjunctive treatment. This study investigates the effects of PBM on reactive oxygen species (ROS), apoptosis, oxidative stress, and inflammatory markers in a periodontitis model [...] Read more.
Periodontitis, an oral disease initiated by a dysbiotic dental biofilm, has an unclear response to photobiomodulation (PBM) as an adjunctive treatment. This study investigates the effects of PBM on reactive oxygen species (ROS), apoptosis, oxidative stress, and inflammatory markers in a periodontitis model using C57BL/6 mice, divided into four groups: control (C), control + PBM (C + PBM), periodontitis (P), and periodontitis + PBM (P + PBM). An infrared diode laser (808 nm, 133.3 J/cm2, 4 J/session) was applied for three days. PBM reduced superoxide anions, hydrogen peroxide, and apoptosis in gingival cells, while decreasing systemic inflammation and protein oxidation. In the P + PBM group, pro-inflammatory cytokines IL-6 and IL-12p70 decreased, whereas IL-10 increased, suggesting improvements in oxidative stress and inflammation profiles. Full article
(This article belongs to the Special Issue Antioxidants as Weapons to Maintain or Restore Oral Health)
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