Cellular Responses of Antioxidants Related to Degenerative Eye Disease Research
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 10 December 2024 | Viewed by 9255
Special Issue Editors
Interests: retinal ganglion cell; glial cells; oxidative stress; mitochondrial dysfunction; mitochondrial protection; neuroinflammation; glaucoma; Alzheimer’s disease
Special Issue Information
Dear Colleagues,
Oxidative stress, mitochondrial dysfunction, and inflammation are critical to degenerative retinal diseases, a group of eye diseases (e.g., age-related macular degeneration, retinal detachment, retinitis pigmentosa, and glaucoma) that cause vision loss. Antioxidants are considered potential therapeutic strategies in retinal eye diseases. In age-related macular degeneration (AMD), retinal pigment epithelial (RPE) cell loss leads to retinal degeneration and visual defects. Dry AMD induces RPE cell degeneration, whereas the wet form causes neovascularization and exudate formation following RPE cell loss. Rhegmatogenous retinal detachment occurs because a tear or hole in the retina leads to vitreous fluid penetrating the sub-retinal space, which induces photoreceptors’ separation from the RPE cell layer. Glaucoma induces progressive retinal ganglion cell (RGC) axon degeneration, resulting in RGC death and visual deficits.
The retina is a thin layer in the posterior part of the eye that collects visual information and transfers it into the brain via the optic nerve. The retina consists of RPE cells, photoreceptor rods and cones, glial cells, and neuronal cells, including RGCs. All layers are essential for vision and are affected by retinal degeneration. RPE cells support the homeostasis of the retina and photoreceptors, complete the heterocycle of outer photoreceptor segments and enable nutrition transport from the choroid and removal of waste material into the choroid. RGCs are the most prominent cell type in the ganglion cell layer, which is the innermost neural layer of the retina. Both RPE and RGC degeneration leads to vision loss, and antioxidants could protect these cells against oxidative stress, mitochondrial dysfunction, and/or inflammation in degenerative retinal eye diseases.
We invite all scientists studying cellular responses of antioxidants related to pre-clinical degenerative retinal eye disease research to participate in this Special Issue. Original research articles, reviews, or shorter perspective articles on all aspects related to antioxidants in degenerative retinal eye diseases are welcome, including topics such as antioxidants, oxidative stress, mitochondrial dysfunction, inflammation, RPE cells, photoreceptors, glia cells, RGCs, and studies of potential new treatment options for retinal degeneration.
Prof. Dr. Wonkyu Ju
Dr. Niina Harju
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- antioxidants
- retinal degeneration
- oxidative stress
- mitochondrial dysfunction
- mitochondrial protection
- inflammation
- retinal eye diseases
- RPE cells
- photoreceptors
- retinal ganglion cells
- glial cells